Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Hepatobiliary neuroendocrine carcinoma: a case report

Authors: Suzana Manxhuka-Kerliu, Gordana Petrusevska, Halit Maloku, Vjollca Sahatciu-Meka, Sadushe Loxha, Naim Loxha, Labinot Shahini

Published in: Journal of Medical Case Reports | Issue 1/2010

Login to get access

Abstract

Introduction

Neuroendocrine carcinoma of the gallbladder is a rather uncommon disease. We report a case of a neuroendocrine tumor that was located in the wall of the gallbladder and that extended into the liver.

Case presentation

A 52-year-old Caucasian woman presented with right-sided abdominal pain, ascites and jaundice. An MRI scan revealed a tumor mass located in the gallbladder wall and involving the liver. A partial hepatectomy and cholecystectomy were performed. Histology revealed a neuroendocrine tumor, which showed scattered Grimelius positive cells and immuno-expressed epithelial and endocrine markers. Our patient is undergoing chemotherapy treatment.

Conclusion

Gastroenteropancreatic neuroendocrine tumors need a multidisciplinary approach, involving immunohistochemistry and molecular-genetic techniques.
Appendix
Available only for authorised users
Literature
1.
go back to reference Rindi G, Bordi C: Endocrine tumours of the gastrointestinal tract: aetiology, molecular pathogenesis and genetics. Clin Gastroenterol. 2005, 19: 519-534. Rindi G, Bordi C: Endocrine tumours of the gastrointestinal tract: aetiology, molecular pathogenesis and genetics. Clin Gastroenterol. 2005, 19: 519-534.
2.
go back to reference Oberg K, Astrup L, Eriksson B, Falkmer SE, Falkmer UG, Gustafsen J, Haglund C, Knigge U, Vatn M, Valimaki M: Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part I--General overview. Acta Oncol. 2004, 43: 617-625. 10.1080/02841860410018575.CrossRefPubMed Oberg K, Astrup L, Eriksson B, Falkmer SE, Falkmer UG, Gustafsen J, Haglund C, Knigge U, Vatn M, Valimaki M: Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part I--General overview. Acta Oncol. 2004, 43: 617-625. 10.1080/02841860410018575.CrossRefPubMed
3.
go back to reference Rindi G, Klöppel G, Alhman H, Caplin M, Couvelard A, de Herder WW, Erikssson B, Falchetti A, Falconi M, Komminoth P, Körner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B: TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch. 2006, 449: 395-401. 10.1007/s00428-006-0250-1.CrossRefPubMedPubMedCentral Rindi G, Klöppel G, Alhman H, Caplin M, Couvelard A, de Herder WW, Erikssson B, Falchetti A, Falconi M, Komminoth P, Körner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B: TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch. 2006, 449: 395-401. 10.1007/s00428-006-0250-1.CrossRefPubMedPubMedCentral
4.
go back to reference Rindi G, de Herder WW, O'Toole D, Wiedenmann B: Consensus guidelines for the management of patients with digestive neuroendocrine tumors: why such guidelines and how we went about it. Neuroendocrinology. 2006, 84: 155-157. 10.1159/000098006.CrossRefPubMed Rindi G, de Herder WW, O'Toole D, Wiedenmann B: Consensus guidelines for the management of patients with digestive neuroendocrine tumors: why such guidelines and how we went about it. Neuroendocrinology. 2006, 84: 155-157. 10.1159/000098006.CrossRefPubMed
5.
go back to reference Strosberg JR, Coppola D, Neumann A, Kvols L: Clinicopathologic analysis of well, moderately and poorly differentiated gastroenteropancreatic neuroendocrine tumors. J Clin Oncol. 2007, 25: 18S- Strosberg JR, Coppola D, Neumann A, Kvols L: Clinicopathologic analysis of well, moderately and poorly differentiated gastroenteropancreatic neuroendocrine tumors. J Clin Oncol. 2007, 25: 18S-
6.
go back to reference Hamilton SR, Aaktonen LA: Pathology & Genetics, Tumors of the Digestive System. WHO. 2000, 214-216. Hamilton SR, Aaktonen LA: Pathology & Genetics, Tumors of the Digestive System. WHO. 2000, 214-216.
7.
go back to reference Thompson GB, van Heerden JA, Grant CS, Carney JA, Ilstrup DM: Islet cell carcinomas of the pancreas: a twenty-year experience. Surgery. 1988, 104: 1011-1017.PubMed Thompson GB, van Heerden JA, Grant CS, Carney JA, Ilstrup DM: Islet cell carcinomas of the pancreas: a twenty-year experience. Surgery. 1988, 104: 1011-1017.PubMed
8.
go back to reference Massironi S, Sciola V, Peracchi M, Ciafardini C, Pia Spampatti M, Conte D: Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol. 2008, 14 (35): 5377-5384. 10.3748/wjg.14.5377.CrossRefPubMedPubMedCentral Massironi S, Sciola V, Peracchi M, Ciafardini C, Pia Spampatti M, Conte D: Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol. 2008, 14 (35): 5377-5384. 10.3748/wjg.14.5377.CrossRefPubMedPubMedCentral
9.
go back to reference Bosl GJ, Yagoda A, Camara LL: Malignant carcinoid of the gallbladder: third reported case and review of the literature. J Surg Oncol. 1980, 13: 215-222. 10.1002/jso.2930130305.CrossRefPubMed Bosl GJ, Yagoda A, Camara LL: Malignant carcinoid of the gallbladder: third reported case and review of the literature. J Surg Oncol. 1980, 13: 215-222. 10.1002/jso.2930130305.CrossRefPubMed
10.
go back to reference Albores-Saavedra J, Henson DE: Tumors of the Gallbladder and Extrahepatic Bile ducts. Radiographics. 2002, 22: 387-413.CrossRef Albores-Saavedra J, Henson DE: Tumors of the Gallbladder and Extrahepatic Bile ducts. Radiographics. 2002, 22: 387-413.CrossRef
11.
go back to reference Yamamoto M, Nakajo S, Miyoshi N, Nakai S, Tahara E: Endocrine cell carcinoma (Carcinoid) of the gallbladder. Am J Surg Pathol. 1989, 13: 292-302.CrossRefPubMed Yamamoto M, Nakajo S, Miyoshi N, Nakai S, Tahara E: Endocrine cell carcinoma (Carcinoid) of the gallbladder. Am J Surg Pathol. 1989, 13: 292-302.CrossRefPubMed
12.
go back to reference Edmondson HA: Tumors of the Liver and Intrahepatic Bile Ducts. Section 7. Fascicle 25. 1958, Washington DC: Armed Forces Institute of Pathology, 193-195. Edmondson HA: Tumors of the Liver and Intrahepatic Bile Ducts. Section 7. Fascicle 25. 1958, Washington DC: Armed Forces Institute of Pathology, 193-195.
13.
go back to reference Iwao M, Nakamura M, Enjoji M, Kubo H, Fukotomi T, Tanabe Y, Nishi H, Taguchi k, Kotoh K, Nawata H: Primary hepatic carcinoid tumor: case report and review of 53 cases. Med Sci Monit. 2001, 7: 746-750.PubMed Iwao M, Nakamura M, Enjoji M, Kubo H, Fukotomi T, Tanabe Y, Nishi H, Taguchi k, Kotoh K, Nawata H: Primary hepatic carcinoid tumor: case report and review of 53 cases. Med Sci Monit. 2001, 7: 746-750.PubMed
14.
go back to reference Albores-Saavedra J, Molberg K, Henson DE: Unusual malignant epithelial tumors of the gallbladder. Semin Diagn Pathol. 1996, 13: 326-338.PubMed Albores-Saavedra J, Molberg K, Henson DE: Unusual malignant epithelial tumors of the gallbladder. Semin Diagn Pathol. 1996, 13: 326-338.PubMed
15.
go back to reference Maitra A, Tascilar M, Hruban RH, Offerhaus GJ, Albores-Saavedra J: Small cell carcinoma of the gallbladder. A clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J Surg Pathol. 2001, 25: 595-601. 10.1097/00000478-200105000-00005.CrossRefPubMed Maitra A, Tascilar M, Hruban RH, Offerhaus GJ, Albores-Saavedra J: Small cell carcinoma of the gallbladder. A clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J Surg Pathol. 2001, 25: 595-601. 10.1097/00000478-200105000-00005.CrossRefPubMed
16.
go back to reference Kazuyoshi N, Masazumi T, Hideak N, Hitoshi I: Composite glandular-endocrine cell carcinoma of the extra-hepatic bile duct: immunohistochemical study. Pathology. 1993, 25: 90-94. 10.3109/00313029309068910.CrossRef Kazuyoshi N, Masazumi T, Hideak N, Hitoshi I: Composite glandular-endocrine cell carcinoma of the extra-hepatic bile duct: immunohistochemical study. Pathology. 1993, 25: 90-94. 10.3109/00313029309068910.CrossRef
17.
go back to reference Albores-Saavedra J, Klimstra D, Henson DE: Tumor of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater. 2000, Washington DC: Armed Forces Institute of Pathology Albores-Saavedra J, Klimstra D, Henson DE: Tumor of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater. 2000, Washington DC: Armed Forces Institute of Pathology
18.
go back to reference Cavazzana AO, Fassima AS, Tollot M, Ninfo V: Small-cell carcinoma of the gallbladder. An immunocytochemical and ultrastructural study. Pathol Res Pract. 1991, 187: 472-476.CrossRefPubMed Cavazzana AO, Fassima AS, Tollot M, Ninfo V: Small-cell carcinoma of the gallbladder. An immunocytochemical and ultrastructural study. Pathol Res Pract. 1991, 187: 472-476.CrossRefPubMed
19.
go back to reference Fujii H, Aotake T, Horiuchi T, Chiba Y, Imamura Y, Tanaka K: Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature. Hepatogastroenterology. 2001, 42: 1588-1593. Fujii H, Aotake T, Horiuchi T, Chiba Y, Imamura Y, Tanaka K: Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature. Hepatogastroenterology. 2001, 42: 1588-1593.
20.
go back to reference de Keizer B, van Aken MO, Feelders RA, de Herder WW, Kam BLR, van Essen M, Krenning EP, Kwekkeboom DJ: Hormonal crises following receptor radionuclide therapy with the radiolabeled somatostatin analogue [177Lu-DOTA0, Tyr3] octreotate. Eur J Nucl Med Mol Imaging. 2008, 35 (4): 749-755. 10.1007/s00259-007-0691-z.CrossRefPubMedPubMedCentral de Keizer B, van Aken MO, Feelders RA, de Herder WW, Kam BLR, van Essen M, Krenning EP, Kwekkeboom DJ: Hormonal crises following receptor radionuclide therapy with the radiolabeled somatostatin analogue [177Lu-DOTA0, Tyr3] octreotate. Eur J Nucl Med Mol Imaging. 2008, 35 (4): 749-755. 10.1007/s00259-007-0691-z.CrossRefPubMedPubMedCentral
21.
go back to reference Kwekkeboom DJ, Teunissen JJ, Bakker WH, Kooij PP, de Herder WW, Feelders RA, van Eijck CH, Esser JP, Kam BL, Krenning EP: Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3] octreotate in patients with endocrine gastroenteropancreatic tumors. J Clin Oncol. 2005, 23: 2754-2762. 10.1200/JCO.2005.08.066.CrossRefPubMed Kwekkeboom DJ, Teunissen JJ, Bakker WH, Kooij PP, de Herder WW, Feelders RA, van Eijck CH, Esser JP, Kam BL, Krenning EP: Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3] octreotate in patients with endocrine gastroenteropancreatic tumors. J Clin Oncol. 2005, 23: 2754-2762. 10.1200/JCO.2005.08.066.CrossRefPubMed
Metadata
Title
Hepatobiliary neuroendocrine carcinoma: a case report
Authors
Suzana Manxhuka-Kerliu
Gordana Petrusevska
Halit Maloku
Vjollca Sahatciu-Meka
Sadushe Loxha
Naim Loxha
Labinot Shahini
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-53

Other articles of this Issue 1/2010

Journal of Medical Case Reports 1/2010 Go to the issue