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01-12-2005 | Case Report

Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system

Authors: C. E. Fiore, S. Riccobene, R. Mangiafico, F. Santoro, P. Pennisi

Published in: Osteoporosis International | Issue 12/2005

Abstract

We report a new case of hepatitis C-associated osteosclerosis (HCAO). The clinical presentation of the patient was an acquired deep severe bone pain with increased serum bone alkaline phosphatase activity (up to 12 times the upper limit of normal), and generalized bone sclerosis, temporally related to the hepatitis C-virus (HCV) infection. We documented in this patient an increase of circulating osteoprotegerin (OPG), and a concentration of circulating receptor activator for nuclear factor-kB ligand (RANKL) below the lower limit of the reference range. The observed abnormalities of the OPG/RANKL system may contribute to the maintenance of the positive balance of bone remodeling that characterizes patients with HCAO.

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Title: Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system
Authors: C. E. Fiore
S. Riccobene
R. Mangiafico
F. Santoro
P. Pennisi
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-005-1858-8

At a glance: The STEP trials

Springer Medicine

Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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