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World Journal of Surgery

Published in:

01-12-2013

Hepatectomy in Elderly Patients: Does Age Matter?

Authors: Yanming Zhou, Xiaofeng Zhang, Zuobing Zhang, Xiaobin Liu, Lupeng Wu, Yumin Li, Bin Li

Published in: World Journal of Surgery | Issue 12/2013

Abstract

Background

With the increase in average life expectancy in recent decades, the proportion of elderly patients requiring liver surgery is rising. The aim of the meta-analysis reported here was to evaluate the safety and efficacy of hepatectomy in elderly patients.

Methods

An extensive electronic search was performed for relevant articles that compare the outcomes of hepatectomy in patients ≥70 years of age with those in younger patients prior to October 2012. Analysis of pooled data was performed with RevMan 5.0.

Results

Twenty-eight observational studies involving 15,480 patients were included in the analysis. Compared with the younger patients, elderly patients experienced more complications (31.8 vs 28.7 %; P = 0.002), mainly as a result of increased cardiac complications (7.5 vs 1.9 %; P < 0.001) and delirium (11.7 vs 4.5 %; P < 0.001). Postoperative major surgical complications (12.6 vs 11.3 %; P = 0.55) and mortality (3.6 vs 3.3 %; P = 0.68) were comparable between elderly and younger patients. For patients with malignancies, both the 5-year disease-free survival (26.5 vs 26.3 %; P = 0.60) and overall survival (39.5 vs 40.7 %; P = 0.29) did not differ significantly between the two groups.

Conclusions

Postoperative major surgical complications, mortality, and long-term results in elderly patients seem to be comparable with those in younger patients, suggesting that age alone should not be considered a contraindication for hepatectomy.

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Title: Hepatectomy in Elderly Patients: Does Age Matter?
Authors: Yanming Zhou
Xiaofeng Zhang
Zuobing Zhang
Xiaobin Liu
Lupeng Wu
Yumin Li
Bin Li
Publication date: 01-12-2013
Publisher: Springer US
Published in: World Journal of Surgery / Issue 12/2013
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-013-2184-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hepatectomy in Elderly Patients: Does Age Matter?

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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