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Intensive Care Medicine
Published in: Intensive Care Medicine 7/2007

01-07-2007 | Correspondence

Heparin-induced thrombocytopenia suspected because of repeated hemofiltration filter clotting

Authors: Sigismond Lasocki, Nadine Ajzenberg, Hervé Quintard, Gaetan Plantefève, Jean-Marie Desmonts, Philippe Montravers

Published in: Intensive Care Medicine | Issue 7/2007

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Excerpt

Diagnosis of heparin-induced thrombocytopenia (HIT) requires a fall of platelet count over a typical onset and is confirmed by the presence of HIT antibodies [1, 2]. HIT during continuous veno-venous hemofiltration (CVVH) has already been reported [3]. We report two consecutive cases in which HIT was diagnosed during CVVH because of clotting of hemofiltration filters without the typical fall in platelet count. …
Literature
1.
Warkentin TE, Greinacher A (2004) Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126:311–337CrossRef
2.
Elalamy I, Lecrubier C, Horellou MH, Conard J, Samama MM (2000) Heparin-induced thrombocytopenia: laboratory diagnosis and management. Ann Med 32(Suppl 1):60–67PubMed
3.
Samuelsson O, Amiral J, Attman PO, Bennegard K, Bjorck S, Larsson G, Tengborn L (1995) Heparin-induced thrombocytopenia during continuous haemofiltration. Nephrol Dial Transplant 10:1768–1771PubMed
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Weismann RE, Tobin RW (1958) Arterial embolism occurring during systemic heparin therapy. AMA Arch Surg 76:219–225; discussion 225–227CrossRefPubMed
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Wester JP, Haas FJ, Biesma DH, Leusink JA, Veth G (2004) Thrombosis and hemorrhage in heparin-induced thrombocytopenia in seriously ill patients. Intensive Care Med 30:1927–1934CrossRefPubMed
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Francis JL (2004) A critical evaluation of assays for detecting antibodies to the heparin–PF4 complex. Semin Thromb Hemost 30:359–368CrossRefPubMed
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Warkentin TE (2005) New approaches to the diagnosis of heparin-induced thrombocytopenia. Chest 127:35–45CrossRef
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Hach-Wunderle V, Kainer K, Krug B, Muller-Berghaus G, Potzsch B (1994) Heparin-associated thrombosis despite normal platelet counts. Lancet 344:469–470PubMed
Metadata
Title
Heparin-induced thrombocytopenia suspected because of repeated hemofiltration filter clotting
Authors
Sigismond Lasocki
Nadine Ajzenberg
Hervé Quintard
Gaetan Plantefève
Jean-Marie Desmonts
Philippe Montravers
Publication date
01-07-2007
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0657-4

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