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Published in: BMC Musculoskeletal Disorders 1/2023

Open Access 01-12-2023 | Hemophilia | Case Report

Physical therapy for end-stage hemophilic arthropathy: a case report

Authors: Zhen-zhen Gao, Hang Yang, Wen-bin Liu, Cui Xu, Shou-chang Xiang, Ling-cong Wang, Ya-jun Mao

Published in: BMC Musculoskeletal Disorders | Issue 1/2023

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Abstract

This report introduces a young adult who has been in bed for more than ten years with end-stage hemophilic arthropathy. He didn’t have access to factor VIII (FVIII) in the early stage of hemophilia due to the high costs of clotting replacement therapy. As a result, he is experiencing some difficulties, such as joint contracture, muscular atrophy, severe pain, and poor function of cardiopulmonary. He came to visit us for a comprehensive rehabilitation program, and, finally, he achieved the basic goal of self-care in daily life.
Literature
1.
2.
go back to reference Prasetyo M, Mongan AE, Chozie NA, Prihartono J, Setiawan SI. Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence. Insights Imaging. 2021;12:107.CrossRefPubMedPubMedCentral Prasetyo M, Mongan AE, Chozie NA, Prihartono J, Setiawan SI. Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence. Insights Imaging. 2021;12:107.CrossRefPubMedPubMedCentral
3.
go back to reference Wang R, Wang Z, Gu Y, Zhang J, Wang P, Tong P, Lv S. Total knee arthroplasty in patients with haemophilic arthropathy is effective and safe according to the outcomes at a mid-term follow-up. J Orthop Traumatol. 2022;23:31.CrossRefPubMedPubMedCentral Wang R, Wang Z, Gu Y, Zhang J, Wang P, Tong P, Lv S. Total knee arthroplasty in patients with haemophilic arthropathy is effective and safe according to the outcomes at a mid-term follow-up. J Orthop Traumatol. 2022;23:31.CrossRefPubMedPubMedCentral
4.
6.
go back to reference Brodin E, Sunnerhagen KS, Baghaei F, Tornbom M. Persons with Haemophilia in Sweden- experiences and strategies in Everyday Life. A single centre study. PLoS ONE. 2015;10:e0139690.CrossRefPubMedPubMedCentral Brodin E, Sunnerhagen KS, Baghaei F, Tornbom M. Persons with Haemophilia in Sweden- experiences and strategies in Everyday Life. A single centre study. PLoS ONE. 2015;10:e0139690.CrossRefPubMedPubMedCentral
7.
go back to reference Scaturro D, Vitagliani F, Tomasello S, Mangano MS, Signa G, Letizia Mauro G. Postural Assessment Systems in the Prevention of Haemophilic Arthropathy: a narrative review. J Funct Morphol Kinesiol. 2022;7(3):68.CrossRefPubMedPubMedCentral Scaturro D, Vitagliani F, Tomasello S, Mangano MS, Signa G, Letizia Mauro G. Postural Assessment Systems in the Prevention of Haemophilic Arthropathy: a narrative review. J Funct Morphol Kinesiol. 2022;7(3):68.CrossRefPubMedPubMedCentral
8.
go back to reference Rodriguez-Merchan EC. Surgical approaches to hemophilic arthropathy. Blood Coagul Fibrinolysis. 2019;30:11–S3.CrossRef Rodriguez-Merchan EC. Surgical approaches to hemophilic arthropathy. Blood Coagul Fibrinolysis. 2019;30:11–S3.CrossRef
9.
go back to reference St-Louis J, Abad A, Funk S, Tilak M, Classey S, Zourikian N, McLaughlin P, Lobet S, Hernandez G, Akins S, Wells AJ, Manco-Johnson M, John J, Austin S, Chowdhary P, Hermans C, Nugent D, Bakeer N, Mangles S, Hilliard P, Blanchette VS, Feldman BM. The Hemophilia Joint Health score version 2.1 validation in adult patients study: a multicenter international study. Res Pract Thromb Haemost. 2022;6:e12690.CrossRefPubMedPubMedCentral St-Louis J, Abad A, Funk S, Tilak M, Classey S, Zourikian N, McLaughlin P, Lobet S, Hernandez G, Akins S, Wells AJ, Manco-Johnson M, John J, Austin S, Chowdhary P, Hermans C, Nugent D, Bakeer N, Mangles S, Hilliard P, Blanchette VS, Feldman BM. The Hemophilia Joint Health score version 2.1 validation in adult patients study: a multicenter international study. Res Pract Thromb Haemost. 2022;6:e12690.CrossRefPubMedPubMedCentral
10.
go back to reference Poonnoose PM, Manigandan C, Thomas R, Shyamkumar NK, Kavitha ML, Bhattacharji S, Srivastava A. Functional independence score in Haemophilia: a new performance-based instrument to measure disability. Haemophilia. 2005;11(6):598–602.CrossRefPubMed Poonnoose PM, Manigandan C, Thomas R, Shyamkumar NK, Kavitha ML, Bhattacharji S, Srivastava A. Functional independence score in Haemophilia: a new performance-based instrument to measure disability. Haemophilia. 2005;11(6):598–602.CrossRefPubMed
11.
12.
go back to reference Chen Lixia ZHANG, Shuyang L. Expert consensus on rehabilitation evaluation and treatment of skeletal muscle Complications of hemophilia in China. Rare Disease Research. 2022;1(04):420–7. Chen Lixia ZHANG, Shuyang L. Expert consensus on rehabilitation evaluation and treatment of skeletal muscle Complications of hemophilia in China. Rare Disease Research. 2022;1(04):420–7.
13.
go back to reference Heim M, Goshen E, Amit Y, Martinowitz U. Synoviorthesis with radioactive yttrium in haemophilia: Israel experience. Haemophilia. 2001;7(Suppl 2):36–9.CrossRefPubMed Heim M, Goshen E, Amit Y, Martinowitz U. Synoviorthesis with radioactive yttrium in haemophilia: Israel experience. Haemophilia. 2001;7(Suppl 2):36–9.CrossRefPubMed
15.
go back to reference Zhu H, Meng Y, Tong P, Zhang S. Pathological mechanism of joint destruction in haemophilic arthropathy. Mol Biol Rep. 2021;48:969–74.CrossRefPubMed Zhu H, Meng Y, Tong P, Zhang S. Pathological mechanism of joint destruction in haemophilic arthropathy. Mol Biol Rep. 2021;48:969–74.CrossRefPubMed
16.
go back to reference Ahn J, Yoo MC, Seo J, Park M, Jeong BO. Comparison of total ankle arthroplasty and ankle arthrodesis in end-stage hemophilic arthropathy. Foot Ankle Int. 2020;41:937–44.CrossRefPubMed Ahn J, Yoo MC, Seo J, Park M, Jeong BO. Comparison of total ankle arthroplasty and ankle arthrodesis in end-stage hemophilic arthropathy. Foot Ankle Int. 2020;41:937–44.CrossRefPubMed
17.
go back to reference Chinese orthopaedic association; group of thrombus and hemostasis CSoH. Expert consensus in perioperative management in hemophilia patients undergoing orthopedic Surgery in China. Chin J Bone Joint Surg. 2016;9(5):361–70. Chinese orthopaedic association; group of thrombus and hemostasis CSoH. Expert consensus in perioperative management in hemophilia patients undergoing orthopedic Surgery in China. Chin J Bone Joint Surg. 2016;9(5):361–70.
18.
go back to reference Acharya SS. Exploration of the pathogenesis of haemophilic joint arthropathy: understanding implications for optimal clinical management. Br J Haematol. 2012;156:13–23.CrossRefPubMed Acharya SS. Exploration of the pathogenesis of haemophilic joint arthropathy: understanding implications for optimal clinical management. Br J Haematol. 2012;156:13–23.CrossRefPubMed
19.
go back to reference Takedani H, Solimeno L, Saxena K, Kalweit L, Mathew P. The Haemophilia Joint Visualizer: development of a personalized, interactive, web-based tool to help improve adherence to prophylaxis. Haemophilia. 2017;23:e155–e8.CrossRefPubMed Takedani H, Solimeno L, Saxena K, Kalweit L, Mathew P. The Haemophilia Joint Visualizer: development of a personalized, interactive, web-based tool to help improve adherence to prophylaxis. Haemophilia. 2017;23:e155–e8.CrossRefPubMed
20.
go back to reference Oyarzun A, Barrientos C, Barahona M, Martinez A, Soto-Arellano V, Courtin C, Cruz-Montecinos C. Knee haemophilic arthropathy care in Chile: midterm outcomes and Complications after total knee arthroplasty. Haemophilia. 2020;26:e179–e86.CrossRefPubMed Oyarzun A, Barrientos C, Barahona M, Martinez A, Soto-Arellano V, Courtin C, Cruz-Montecinos C. Knee haemophilic arthropathy care in Chile: midterm outcomes and Complications after total knee arthroplasty. Haemophilia. 2020;26:e179–e86.CrossRefPubMed
21.
go back to reference Ernstbrunner L, Hingsammer A, Catanzaro S, Sutter R, Brand B, Wieser K, Fucentese SF. Long-term results of total knee arthroplasty in haemophilic patients: an 18-year follow-up. Knee Surg Sports Traumatol Arthrosc. 2017;25:3431–8.CrossRefPubMed Ernstbrunner L, Hingsammer A, Catanzaro S, Sutter R, Brand B, Wieser K, Fucentese SF. Long-term results of total knee arthroplasty in haemophilic patients: an 18-year follow-up. Knee Surg Sports Traumatol Arthrosc. 2017;25:3431–8.CrossRefPubMed
22.
go back to reference Heeg M, Meyer K, Smid WM, Van Horn JR, Van der Meer J. Total knee and hip arthroplasty in haemophilic patients. Haemophilia. 1998;4(5):747–51.CrossRefPubMed Heeg M, Meyer K, Smid WM, Van Horn JR, Van der Meer J. Total knee and hip arthroplasty in haemophilic patients. Haemophilia. 1998;4(5):747–51.CrossRefPubMed
23.
go back to reference He BJ, Mao Q, Li J, Lv SJ, Tong P, Jin HT. Bilateral synchronous total hip arthroplasty for end-stage arthropathy in hemophilia A patients: a retrospective study. Med (Baltim). 2022;101(27):e29667.CrossRef He BJ, Mao Q, Li J, Lv SJ, Tong P, Jin HT. Bilateral synchronous total hip arthroplasty for end-stage arthropathy in hemophilia A patients: a retrospective study. Med (Baltim). 2022;101(27):e29667.CrossRef
24.
go back to reference Kargarfard M, Dehghadani M, Ghias R. The effect of aquatic Exercise Therapy on muscle strength and Joint’s range of motion in Hemophilia patients. Int J Prev Med. 2013;4:50–6.PubMedPubMedCentral Kargarfard M, Dehghadani M, Ghias R. The effect of aquatic Exercise Therapy on muscle strength and Joint’s range of motion in Hemophilia patients. Int J Prev Med. 2013;4:50–6.PubMedPubMedCentral
25.
go back to reference Elshennawy S, Zahreldin AA, Mortada H, Hozien M, Youssef ASA, Galal A, Shahien M, Elfeky A, Elaraby A, Hamed M. The efficacy of physical therapy modalities in patients with Hemophilia: a systematic review of Randomized controlled trials with Meta-analysis. Arch Phys Med Rehabil. 2023;104:475–89.CrossRefPubMed Elshennawy S, Zahreldin AA, Mortada H, Hozien M, Youssef ASA, Galal A, Shahien M, Elfeky A, Elaraby A, Hamed M. The efficacy of physical therapy modalities in patients with Hemophilia: a systematic review of Randomized controlled trials with Meta-analysis. Arch Phys Med Rehabil. 2023;104:475–89.CrossRefPubMed
26.
go back to reference Scaturro DBM, Lomonaco G. Effectiveness of rehabilitation on pain and function in people affected by hemophilia: Erratum. Med (Baltim). 2022;101:e28715.CrossRef Scaturro DBM, Lomonaco G. Effectiveness of rehabilitation on pain and function in people affected by hemophilia: Erratum. Med (Baltim). 2022;101:e28715.CrossRef
27.
go back to reference Donoso-Ubeda E, Merono-Gallut J, Lopez-Pina JA, Cuesta-Barriuso R. Effect of manual therapy in patients with hemophilia and ankle arthropathy: a randomized clinical trial. Clin Rehabil. 2020;34:111–9.CrossRefPubMed Donoso-Ubeda E, Merono-Gallut J, Lopez-Pina JA, Cuesta-Barriuso R. Effect of manual therapy in patients with hemophilia and ankle arthropathy: a randomized clinical trial. Clin Rehabil. 2020;34:111–9.CrossRefPubMed
28.
go back to reference Cuesta-Barriuso R, Gomez-Conesa A, Lopez-Pina JA. The effectiveness of manual therapy in addition to passive stretching exercises in the treatment of patients with haemophilic knee arthropathy: a randomized, single-blind clinical trial. Haemophilia. 2021;27:e110–e8.CrossRefPubMed Cuesta-Barriuso R, Gomez-Conesa A, Lopez-Pina JA. The effectiveness of manual therapy in addition to passive stretching exercises in the treatment of patients with haemophilic knee arthropathy: a randomized, single-blind clinical trial. Haemophilia. 2021;27:e110–e8.CrossRefPubMed
29.
go back to reference Perez-Llanes R, Merono-Gallut J, Donoso-Ubeda E, Lopez-Pina J, Cuesta-Barriuso R. Safety and effectiveness of fascial therapy in the treatment of adult patients with hemophilic elbow arthropathy: a pilot study. Physiother Theory Pract. 2022;38:276–85.CrossRefPubMed Perez-Llanes R, Merono-Gallut J, Donoso-Ubeda E, Lopez-Pina J, Cuesta-Barriuso R. Safety and effectiveness of fascial therapy in the treatment of adult patients with hemophilic elbow arthropathy: a pilot study. Physiother Theory Pract. 2022;38:276–85.CrossRefPubMed
30.
go back to reference Tat AM, Can F, Tat NM, Sasmaz HI, Antmen AB. The effects of manual therapy and exercises on pain, muscle strength, joint health, functionality and quality of life in haemophilic arthropathy of the elbow joint: a randomized controlled pilot study. Haemophilia. 2021;27:e376–e84.PubMed Tat AM, Can F, Tat NM, Sasmaz HI, Antmen AB. The effects of manual therapy and exercises on pain, muscle strength, joint health, functionality and quality of life in haemophilic arthropathy of the elbow joint: a randomized controlled pilot study. Haemophilia. 2021;27:e376–e84.PubMed
31.
go back to reference Rodriguez-Merchan EC. Hemophilic arthropathy: a teaching approach devoted to hemophilia treaters in under-development countries. Expert Rev Hematol. 2021;14:887–96.CrossRefPubMed Rodriguez-Merchan EC. Hemophilic arthropathy: a teaching approach devoted to hemophilia treaters in under-development countries. Expert Rev Hematol. 2021;14:887–96.CrossRefPubMed
32.
go back to reference Jorge Filho D, Battistella LR, Lourenço C. Computerized pedobarography in the characterization of ankle-foot instabilities of haemophilic patients. Haemophilia. 2006;12:140–6.CrossRefPubMed Jorge Filho D, Battistella LR, Lourenço C. Computerized pedobarography in the characterization of ankle-foot instabilities of haemophilic patients. Haemophilia. 2006;12:140–6.CrossRefPubMed
33.
go back to reference Blamey G, Forsyth A, Zourikian N, Short L, Jankovic N, De Kleijn P, Flannery T. Comprehensive elements of a physiotherapy exercise programme in haemophilia–a global perspective. Haemophilia. 2010;16(Suppl 5):136–45.CrossRefPubMed Blamey G, Forsyth A, Zourikian N, Short L, Jankovic N, De Kleijn P, Flannery T. Comprehensive elements of a physiotherapy exercise programme in haemophilia–a global perspective. Haemophilia. 2010;16(Suppl 5):136–45.CrossRefPubMed
Metadata
Title
Physical therapy for end-stage hemophilic arthropathy: a case report
Authors
Zhen-zhen Gao
Hang Yang
Wen-bin Liu
Cui Xu
Shou-chang Xiang
Ling-cong Wang
Ya-jun Mao
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2023
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-023-07056-8

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