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01-02-2016 | ORIGINAL ARTICLE

Heme Oxygenase-1 Promoter Polymorphism Protects Liver Allograft

Authors: Zheng-Yun Zhang, Jiao Guan, Hao Li, Zun-Qiang Zhou, Guang-Wen Zhou

Published in: Indian Journal of Surgery | Issue 1/2016

Abstract

Heme oxygenase-1 has been identified to protect allograft from ischemia/reperfusion and immunologic rejection. Activity of heme oxygenase-1 is regulated by a guanine-thymine dinucleotide length polymorphism in the heme oxygenase-1 gene promoter. In this study, we aimed to explore the impact of the heme oxygenase-1 gene promoter polymorphism of donors and recipients on the orthotopic liver graft function after transplantation. Sixty recipients and their accompanying donors of orthotopic liver allografts were included retrospectively in this study. Heme oxygenase-1 gene promoter polymorphism was assessed using genomic DNA isolated from cryopreserved splenocytes or peripheral blood mononuclear cells and analyzed by genetic analyzer. Small allele of the donor heme oxygenase-1 gene polymorphism significantly prolonged the graft survival (p = 0.017). Recipients of allografts from a class of small-allele carrier had significantly lower serum total bilirubin compared with recipients of a nonclass small-allele donor liver (p < 0.01). Additionally, in recipients of small-carrier allografts, cold ischemia time (<10 h or ≥10 h) did not affect the total bilirubin significantly. Our study suggested a protective function of donor-derived heme oxygenase-1 gene promoter polymorphism on orthotopic liver allograft function after transplantation.

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Title: Heme Oxygenase-1 Promoter Polymorphism Protects Liver Allograft
Authors: Zheng-Yun Zhang
Jiao Guan
Hao Li
Zun-Qiang Zhou
Guang-Wen Zhou
Publication date: 01-02-2016
Publisher: Springer India
Published in: Indian Journal of Surgery / Issue 1/2016
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI: https://doi.org/10.1007/s12262-015-1309-5

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Springer Medicine

Heme Oxygenase-1 Promoter Polymorphism Protects Liver Allograft

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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