Top

Published in:

01-11-2017 | Original Article

Hematological changes in yellowfin seabream (Acanthopagrus latus) following chronic exposure to bisphenol A

Authors: Zeinab Yaghoobi, Alireza Safahieh, Mohammad Taghi Ronagh, Abdulali Movahedinia, Seyed Mohammad Mousavi

Published in: Comparative Clinical Pathology | Issue 6/2017

Abstract

Bisphenol A (BPA) is one of the industrial chemical compounds which is produced in large volume throughout the world. It is a monomeric compound that is used in the manufacture of polycarbonate plastics and epoxy resins. The widespread use of BPA and its entry to aquatic ecosystems are serious problems. The aim of this study is to assess the change in the hematological parameters of Acanthopagrus latus as biomarkers after exposure to BPA in low concentrations at 1, 5, 10, and 50 (μg/g BPA). The experimental period was 21 days, and the injections were conducted in 0, 7, and 14 days in complete dose form. The blood collection from fishes was carried out in 14 and 21 days. Hematological profile, including red blood cells (RBCs), hematocrit (Ht), hemoglobin (Hb), MCH, MCV, MCHC, and white blood cell differential counts (lymphocytes, monocytes, basophils, eosinophils, and neutrophils) was conducted. The results of this study indicated that BPA has an inverse correlation with fish hematological parameter abnormalities; increasing concentration of BPA leads to a decrease in the RBC, Ht, Hb, secondary indices, and lymphocytes. Therefore, it was concluded that all the studied hematological parameters can be used as biomarkers for the presence of xenobiotic such as BPA in the natural environment.

Available from http://www.statisticshowto.com/tables/f-table/.

Abalaka SE (2013) Evaluation of the haematology and biochemistry of Clarias gariepinus as biomarkers of environmental pollution in Tiga dam, Nigeria. Braz Arch Biol Technol 56:371–376. doi:10.1590/S1516-89132013000300004 CrossRef

Abou Khalil N, Abd-Elkareem M, Sayed A (2017) Nigella sativa seed protects against 4-nonylphenol-induced haematotoxicity in Clarias gariepinus (Burchell, 1822): oxidant/antioxidant rebalance. Aquac Nutr. doi:10.1111/anu.12522

Adedeji O, Adeyemo O, Agbede S (2009) Effects of diazinon on blood parameters in the African catfish (Clarias gariepinus). Afr J Biotechnol 8:3940

Adhikari S, Sarkar B, Chatterjee A et al (2004) Effects of cypermethrin and carbofuran on certain hematological parameters and prediction of their recovery in a freshwater teleost, Labeo rohita (Hamilton). Ecotoxicol Environ Saf 58:220–226. doi:10.1016/j.ecoenv.2003.12.003 CrossRefPubMed

Aghajanpour-Mir SM, Zabihi E, Akhavan-Niaki H et al (2016) The genotoxic and cytotoxic effects of bisphenol-a (BPA) in MCF-7 cell line and amniocytes. Int J Mol Cell Med 5:19PubMedPubMedCentral

Ahmed W, Moselhy W, Nabil T (2015) Bisphenol A toxicity in adult male rats: hematological, biochemical and histopathological approach. Glob Veternaria 14:228–238

Babadi S, Safahiye A, Nabavi SMB, et al. (2014) The distribution mode of mercury in the different Acanthopagrus latus tissues, Moses estuary, Persian Gulf. Fisheries publication, Natural resources of Iran 68

Babu S, Uppu S, Claville MO et al (2013) Prooxidant actions of bisphenol A (BPA) phenoxyl radicals: implications to BPA-related oxidative stress and toxicity. Toxicol Mech Methods 23:273–280. doi:10.3109/15376516.2012.753969 CrossRefPubMed

Bakker J, te Biesenbeek J, Boon P, et al. (2014) Bisphenol A: part 1. Facts and figures on human and environmental health issues and regulatory perspectives. RIVM rapport 601351001

Belfroid A, van Velzen M, van der Horst B et al (2002) Occurrence of bisphenol A in surface water and uptake in fish: evaluation of field measurements. Chemosphere 49:97–103. doi:10.1016/S0045-6535(02)00157-1 CrossRefPubMed

Bhagwant S, Bhikajee M (2000) Induction of hypochromic macrocytic anaemia in Oreochromis hybrid (cichlidae) exposed to 100mg/l (sublethal dose) of aluminium. Univ Mauritius Res J 5:9–20

Bhandari RK, Deem SL, Holliday DK et al (2015) Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species. Gen Comp Endocrinol 214:195–219. doi:10.1016/j.ygcen.2014.09.014 CrossRefPubMed

Bindhumol V, Chitra K, Mathur P (2003) Bisphenol A induces reactive oxygen species generation in the liver of male rats. Toxicology 188:117–124. doi:10.1016/S0300-483X(03)00056-8 CrossRefPubMed

Borst O, Abed M, Alesutan I et al (2012) Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX. Am J Phys Cell Phys 302:C644–C651. doi:10.1152/ajpcell.00340.2011 CrossRef

Canesi L, Fabbri E (2015) Environmental effects of BPA focus on aquatic species. Dose-Response 13:1559325815598304. doi:10.1177/1559325815598304 CrossRefPubMedPubMedCentral

Carlisle J, Chan D, Golub M, et al. (2009) Toxicological profile for bisphenol A. D. Seigel (ed.), Office of Environmental Health Hazard Assessment. Prepared for Ocean Protection Council

Chitra K, Latchoumycandane C, Mathur P (2003) Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Toxicology 185:119–127. doi:10.1016/S0300-483X(02)00597-8 CrossRefPubMed

Cossins AR, Crawford DL (2005) Fish as models for environmental genomics. Nat Rev Genet 6:324–333. doi:10.1038/nrg1590 CrossRefPubMed

Cypher AD, Ickes JR, Bagatto B (2015) Bisphenol A alters the cardiovascular response to hypoxia in Danio rerio embryos. Comp Biochem Physio C Toxicol Pharmacol 174:39–45. doi:10.1016/j.cbpc.2015.06.006 CrossRef

de Carvalho PSM (2013) Behavioral biomarkers and pollution risks to fish health and biodiversity. In: Pollution and Fish Health in Tropical Ecosystems. CRC Press, pp 350–377

Desai B, Parikh P (2012) Impact of curzate (fungicide) on hematological parameters of Oreochromis mossambicus. Internat J Sci Engineer Res 3:1–6

Fazio F, Faggio C, Marafioti S et al (2013) Effect of water quality on hematological and biochemical parameters of Gobius niger caught in Faro lake (Sicily). Iran J Fish Sci 12:219–231

Flint S, Markle T, Thompson S et al (2012) Bisphenol A exposure, effects, and policy: a wildlife perspective. J Environ Manag 104:19–34. doi:10.1016/j.jenvman.2012.03.021 CrossRef

Gernhöfer M, Pawert M, Schramm M et al (2001) Ultrastructural biomarkers as tools to characterize the health status of fish in contaminated streams. J Aquat Ecosyst Stress Recover 8:241–260. doi:10.1023/A:1012958804442 CrossRef

Hedayati A, Khsoravi Katuli K (2016) Impact of mercury on liver and ovary of yellowfin sea bream (Acanthopagrus latus) in the Persian Gulf. ECOPERSIA 4:1295–1312CrossRef

Hedayati A, Safahieh A, Savar A et al (2010) Assessment of aminotransferase enzymes in yellowfin sea bream (Acanthopagrus latus) under experimental condition as biomarkers of mercury pollution. World J Fish Mar Sci 2:186–192

Hesp SA, Potter IC, Hall NG (2004) Reproductive biology and protandrous hermaphroditism in Acanthopagrus latus. Environ Biol Fish 70:257–272. doi:10.1023/B:EBFI.0000033344.21383.00 CrossRef

Houston A (1990) Blood and circulation. Methods for fish biology 1990:273–334

Howdeshell KL, Hotchkiss AK, Thayer KA et al (1999) Environmental toxins: exposure to bisphenol A advances puberty. Nature 401:763–764. doi:10.1038/44517 CrossRefPubMed

Ibrahim HA, Fouda MI, Yahya RS et al (2014) Erythrocyte phosphatidylserine exposure in β-thalassemia. Lab Hematol 20:9–14. doi:10.1532/LH96.12016 CrossRefPubMed

Kavitha C, Malarvizhi A, Kumaran SS et al (2010) Toxicological effects of arsenate exposure on hematological, biochemical and liver transaminases activity in an Indian major carp, Catla catla. Food Chem Toxicol 48:2848–2854. doi:10.1016/j.fct.2010.07.017 CrossRefPubMed

Keum Y-H, Jee J-H, Lee O-H et al (2005) In vivo effects of bisphenol A exposure on haematological parameters in Korean rockfish, Sebastes schlegeli. J Fish Pathol 18:293–300

Khoshbavar-Rostami H, Soltani M, Hassan H (2006) Immune response of great sturgeon (Huso huso) subjected to long-term exposure to sublethal concentration of the organophosphate, diazinon. Aquaculture 256:88–94. doi:10.1016/j.aquaculture.2006.02.041 CrossRef

Kulkeaw K, Sugiyama D (2012) Zebrafish erythropoiesis and the utility of fish as models of anemia. Stem Cell Res Ther 3:55. doi:10.1186/scrt146 CrossRefPubMedPubMedCentral

Lang E, Lang F (2015) Mechanisms and pathophysiological significance of eryptosis, the suicidal erythrocyte death. Semin cell Dev Biol:35–42. doi:10.1016/j.semcdb.2015.01.009

Lang IA, Galloway TS, Scarlett A et al (2008) Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 300:1303–1310. doi:10.1001/jama.300.11.1303 CrossRefPubMed

Maćczak A, Cyrkler M, Bukowska B et al (2016) Eryptosis-inducing activity of bisphenol A and its analogs in human red blood cells (in vitro study). J Hazard Mater 307:328–335. doi:10.1016/j.jhazmat.2015.12.057 CrossRefPubMed

Madhu S and Pooja C. (2015) Acute toxicity of 4-nonylphenRes J Recent Sciol on haemotological profile of fresh water fish Channa punctatus. 2277: 2502

Meeker JD, Calafat AM, Hauser R (2010) Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic. Environ Sci Technol 44:1458. doi:10.1021/es9028292 CrossRefPubMedPubMedCentral

Mekkawy IA, Mahmoud UM, Sayed AE-DH (2011) Effects of 4-nonylphenol on blood cells of the African catfish Clarias gariepinus (Burchell, 1822). Tissue Cell 43:223–229. doi:10.1016/j.tice.2011.03.006 CrossRefPubMed

Melzer D, Rice NE, Lewis C et al (2010) Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One 5:e8673. doi:10.1371/journal.pone.0008673 CrossRefPubMedPubMedCentral

Milla S, Depiereux S, Kestemont P (2011) The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review. Ecotoxicology 20:305–319. doi:10.1007/s10646-010-0588-7 CrossRefPubMed

Narra MR (2017) Haematological and immune upshots in Clarias batrachus exposed to dimethoate and defying response of dietary ascorbic acid. Chemosphere 168:988–995. doi:10.1016/j.chemosphere.2016.10.112 CrossRefPubMed

Nunes B, Gaio A, Carvalho F et al (2008) Behaviour and biomarkers of oxidative stress in Gambusia holbrooki after acute exposure to widely used pharmaceuticals and a detergent. Ecotoxicol Environ Saf 71:341–354. doi:10.1016/j.ecoenv.2007.12.006 CrossRefPubMed

Onyia L, Michael K, Ekoto B (2013) Haematological profile, blood group and genotype of Heterobranchus bidorsalis. Net J Agric Sci 1:69–72

Pait AS, Nelson JO (2003) Vitellogenesis in male Fundulusheteroclitus (killifish) induced by selected estrogenic compounds. Aquat Toxicol 64:331–342. doi:10.1016/S0166-445X(03)00060-2 CrossRefPubMed

Peters G and Schwarzer R. (1985) Changes in hemopoietic tissue of rainbow trout under influence of stress. Diseases of aquatic organisms

Phuong LM, Damsgaard C, Ishimatsu A et al (2017) Recovery of blood gases and haematological parameters upon anaesthesia with benzocaine, MS-222 or Aqui-S in the air-breathing catfish Pangasianodon hypophthalmus. Ichthyol Res 64:84–92. doi:10.1007/s10228-016-0545-4 CrossRef

Qiu W, Chen J, Li Y et al (2016) Oxidative stress and immune disturbance after long-term exposure to bisphenol A in juvenile common carp (Cyprinus carpio). Ecotoxicol Environ Saf 130:93–102. doi:10.1016/j.ecoenv.2016.04.014 CrossRefPubMed

Rao JV (2006) Biochemical alterations in euryhaline fish, Oreochromis mossambicus exposed to sub-lethal concentrations of an organophosphorus insecticide, monocrotophos. Chemosphere 65:1814–1820. doi:10.1016/j.chemosphere.2006.04.015 CrossRefPubMed

Reynaud S, Deschaux P (2006) The effects of polycyclic aromatic hydrocarbons on the immune system of fish: a review. Aquat Toxicol 77:229–238. doi:10.1016/j.aquatox.2005.10.018 CrossRefPubMed

Roberts R (2001) The anatomy and physiology of teleosts. Fish Pathol:12–54

Rogers JA, Mirza RS (2013) The effects of bisphenol-A on the immune system of wild yellow perch, Perca flavescens. Water Air Soil Pollut 224:1728. doi:10.1007/s11270-013-1728-5 CrossRef

Savill J, Wyllie A, Henson J et al (1989) Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83:865. doi:10.1172/JCI113970 CrossRefPubMedPubMedCentral

Sowemimo-Coker SO (2002) Red blood cell hemolysis during processing. Transfus Med Rev 16:46–60. doi:10.1053/tmrv.2002.29404 CrossRefPubMed

Svoboda M, Luskova V, Drastichova J et al (2001) The effect of diazinon on haematological indices of common carp (Cyprinus carpio L.) Acta Vet Brno 70:457–465CrossRef

Thien K. (2009) Bis-phenol A: origin, fate, dilemma and the effects of increased background organics on its adsorption by powdered activated carbon. TAMK University of Applied Sciences. 41p

Ulutaş OK, Yıldız N, Durmaz E et al (2011) An in vivo assessment of the genotoxic potential of bisphenol A and 4-tert-octylphenol in rats. Arch Toxicol 85:995–1001. doi:10.1007/s00204-010-0620-y CrossRefPubMed

Uribe C, Folch H, Enriquez R et al (2011) Innate and adaptive immunity in teleost fish: a review. Veterinarni Medicina 56:486–503

Van der Oost R, Beyer J, Vermeulen NP (2003) Fish bioaccumulation and biomarkers in environmental risk assessment: a review. Environ Toxicol Pharmacol 13:57–149. doi:10.1016/S1382-6689(02)00126-6 CrossRefPubMed

Van Vuren J (1986) The effects of toxicants on the haematology of Labeo umbratus (Teleostei: Cyprinidae). Comp Biochem Physiol Part C Compar Pharmacol 83:155–159. doi:10.1016/0742-8413(86)90029-0 CrossRef

Vandenberg LN, Ehrlich S, Belcher SM et al (2013) Low dose effects of bisphenol A: an integrated review of in vitro, laboratory animal, and epidemiology studies. Endocrine disruptors 1:e26490. doi:10.4161/endo.26490 CrossRef

Vázquez GR, Nostro FL (2014) Changes in hematological parameters of Cichlasoma dimerus (Teleostei, Perciformes) exposed to sublethal concentrations of 4-tert-octylphenol. Arch Environ Contam Toxicol 66:463–469. doi:10.1007/s00244-014-9997-6 CrossRef

Verde, C., D. Giordano & G. di Prisco, 2011b. Erythropoiesis in fishes. In Farrell, T. (ed.), On-Line Encyclopaedia of Fish Physiology, from Genome to Environment, Vol. 2. Academic Press, San Diego: 992–997. doi:10.1016/B978-0-12-374553-8.00268-9

Verslycke T, Vandenbergh GF, Versonnen B et al (2002) Induction of vitellogenesis in 17α-ethinylestradiol-exposed rainbow trout (Oncorhynchus mykiss): a method comparison. Comp Biochem Physiol Part C Toxicol Pharmacol 132:483–492. doi:10.1016/S1532-0456(02)00111-4 CrossRef

Wei X, Huang Y, Wong MH et al (2011) Assessment of risk to humans of bisphenol A in marine and freshwater fish from Pearl River Delta, China. Chemosphere 85:122–128. doi:10.1016/j.chemosphere.2011.05.038 CrossRefPubMed

Wepener V, Vuren J, Preez H (1992) Effect of manganese and iron at a neutral and acidic pH on the hematology of the banded tilapia (Tilapia sparrmanii). Bull Environ Contam Toxicol 49:613–619. doi:10.1016/j.chemosphere.2011.05.038 CrossRefPubMed

Wozniak M, Murias M (2008) Xenoestrogens: endocrine disrupting compounds. Ginekol Pol 79:785–790PubMed

Yang YJ, Hong Y-C, Oh S-Y et al (2009) Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women. Environ Res 109:797–801. doi:10.1016/j.envres.2009.04.014 CrossRefPubMed

Zhang J, Cooke GM, Curran IH et al (2011) GC–MS analysis of bisphenol A in human placental and fetal liver samples. J Chromatogr B 879:209–214. doi:10.1016/j.jchromb.2010.11.031 CrossRef

Zhu P, Tang Y, Fan J et al (2017) Hematological parameters and blood cell morphology of male and female Schizothorax (Racoma) davidi (Sauvage). J World Aquacult Soc. doi:10.1111/jwas.12397

Title: Hematological changes in yellowfin seabream (Acanthopagrus latus) following chronic exposure to bisphenol A
Authors: Zeinab Yaghoobi
Alireza Safahieh
Mohammad Taghi Ronagh
Abdulali Movahedinia
Seyed Mohammad Mousavi
Publication date: 01-11-2017
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 6/2017
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-017-2530-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Hematological changes in yellowfin seabream (Acanthopagrus latus) following chronic exposure to bisphenol A

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2017

Blood chemistry, haematology and ileal bacterial counts of broilers fed fermented mixture of cassava root meal and palm kernel cake

Modulation of cholinergic, monoaminergic, and purinergic enzymes of the brain functions by bitter (Vernonia amygdalina) and water bitter (Struchium sparganophora) leaves extracts: comparison of phenolic constituents versus nootropic potentials

Genotypic identification of methicillin resistance and virulence factors in Staphylococcus spp. from bovine mastitis milk

Endobronchial lipoma, the initial evaluation and appropriate management

Short- and long-term exposure to imidacloprid disturbs the elemental composition and free amino acid profile in muscles of Labeo rohita

Effects of acclimation to seawater salinity on some blood parameters in wild Caspian brown trout, Salmo trutta caspius