Skip to main content
Top
Published in: BMC Health Services Research 1/2007

Open Access 01-12-2007 | Correspondence

HEE-GER: a systematic review of German economic evaluations of health care published 1990–2004

Authors: David LB Schwappach, Till A Boluarte

Published in: BMC Health Services Research | Issue 1/2007

Login to get access

Abstract

Background

Studies published in non-English languages are systematically missing in systematic reviews of growth and quality of economic evaluations of health care. The aims of this study were: to characterize German evaluations, published in English or German-language, in terms of various key parameters; to investigate methods to derive quality-of-life weights in cost-utility studies; and to examine changes in study characteristics over the years.

Methods

We conducted a country-specific systematic review of the German and English-language literature of German economic evaluations (assessment of or application to the German health care system) published 1990–2004. Generic and specialized health economic databases were searched. Two independent reviewers verified fulfillment of inclusion criteria and extracted study characteristics.

Results

The fulltexts of 730 articles were reviewed of which 283 fulfilled all entry criteria. 32% of included studies were published in German-language. 51% of studies evaluated pharmaceuticals and 63% were cost-effectiveness analyses. Economic appraisals concentrate on few disease categories and important health areas are strongly underrepresented. Declaration of sponsorship was associated with article language (49% English articles vs. 29% German articles, p < 0.001). The methodology used to obtain quality-of-life weights in published cost-utility studies was very diverse, poorly reported and most studies did not use German patients' or community health state valuations.

Conclusion

Many of the German-language evaluations included in our study are likely to be missing in international reviews and may be systematically different from English-language reviews from Germany. Lack of transparency and adherence to recommended reporting practices constitute a serious problem in German economic evaluations.
Appendix
Available only for authorised users
Literature
1.
go back to reference Neumann PJ, Greenberg D, Olchanski NV, Stone PW, Rosen AB: Growth and Quality of the Cost-Utility Literature, 1976–2001. Value Health. 2005, 8: 3-9. 10.1111/j.1524-4733.2005.04010.x.PubMedCrossRef Neumann PJ, Greenberg D, Olchanski NV, Stone PW, Rosen AB: Growth and Quality of the Cost-Utility Literature, 1976–2001. Value Health. 2005, 8: 3-9. 10.1111/j.1524-4733.2005.04010.x.PubMedCrossRef
2.
go back to reference Barbieri M, Drummond M, Willke R, Chancellor J, Jolain B, Towse A: Variability of Cost-Effectiveness Estimates for Pharmaceuticals in Western Europe: Lessons for Inferring Generalizability. Value Health. 2005, 8: 10-23. 10.1111/j.1524-4733.2005.03070.x.PubMedCrossRef Barbieri M, Drummond M, Willke R, Chancellor J, Jolain B, Towse A: Variability of Cost-Effectiveness Estimates for Pharmaceuticals in Western Europe: Lessons for Inferring Generalizability. Value Health. 2005, 8: 10-23. 10.1111/j.1524-4733.2005.03070.x.PubMedCrossRef
3.
go back to reference Rosen AB, Greenberg D, Stone PW, Olchanski NV, Neumann PJ: Quality of abstracts of papers reporting original cost-effectiveness analyses. Med Decis Making. 2005, 25: 424-428. 10.1177/0272989X05278932.PubMedCrossRef Rosen AB, Greenberg D, Stone PW, Olchanski NV, Neumann PJ: Quality of abstracts of papers reporting original cost-effectiveness analyses. Med Decis Making. 2005, 25: 424-428. 10.1177/0272989X05278932.PubMedCrossRef
4.
go back to reference Stone PW, Chapman RH, Sandberg EA, Liljas B, Neumann PJ: Measuring costs in cost-utility analyses. Variations in the literature. Int J Technol Assess Health Care. 2000, 16: 111-124. 10.1017/S0266462300161100.PubMedCrossRef Stone PW, Chapman RH, Sandberg EA, Liljas B, Neumann PJ: Measuring costs in cost-utility analyses. Variations in the literature. Int J Technol Assess Health Care. 2000, 16: 111-124. 10.1017/S0266462300161100.PubMedCrossRef
5.
go back to reference Hill SR, Mitchell AS, Henry DA: Problems with the interpretation of pharmacoeconomic analyses. JAMA. 2000, 283: 2116-2121. 10.1001/jama.283.16.2116.PubMedCrossRef Hill SR, Mitchell AS, Henry DA: Problems with the interpretation of pharmacoeconomic analyses. JAMA. 2000, 283: 2116-2121. 10.1001/jama.283.16.2116.PubMedCrossRef
6.
go back to reference Doshi JA, Glick HA, Polsky D: Analyses of cost data in economic evaluations conducted alongside randomized controlled trials. Value Health. 2006, 9: 334-340. 10.1111/j.1524-4733.2006.00122.x.PubMedCrossRef Doshi JA, Glick HA, Polsky D: Analyses of cost data in economic evaluations conducted alongside randomized controlled trials. Value Health. 2006, 9: 334-340. 10.1111/j.1524-4733.2006.00122.x.PubMedCrossRef
7.
go back to reference Armstrong R, Jackson N, Doyle J, Waters E, Howes F: Its in your hands: the value of handsearching in conducting systematic reviews of public health interventions. J Public Health (Oxf). 2005, 27: 388-391. 10.1093/pubmed/fdi056.CrossRef Armstrong R, Jackson N, Doyle J, Waters E, Howes F: Its in your hands: the value of handsearching in conducting systematic reviews of public health interventions. J Public Health (Oxf). 2005, 27: 388-391. 10.1093/pubmed/fdi056.CrossRef
8.
go back to reference Pignone M, Saha S, Hoerger T, Lohr KN, Teutsch S, Mandelblatt J: Challenges in systematic reviews of economic analyses. Ann Intern Med. 2005, 142: 1073-1079.PubMedCrossRef Pignone M, Saha S, Hoerger T, Lohr KN, Teutsch S, Mandelblatt J: Challenges in systematic reviews of economic analyses. Ann Intern Med. 2005, 142: 1073-1079.PubMedCrossRef
9.
go back to reference Sassi F, Archard L, McDaid D: Searching literature databases for health care economic evaluations: how systematic can we afford to be?. Med Care. 2002, 40: 387-394. 10.1097/00005650-200205000-00004.PubMedCrossRef Sassi F, Archard L, McDaid D: Searching literature databases for health care economic evaluations: how systematic can we afford to be?. Med Care. 2002, 40: 387-394. 10.1097/00005650-200205000-00004.PubMedCrossRef
10.
go back to reference Richardson G, Manca A: Calculation of quality adjusted life years in the published literature: a review of methodology and transparency. Health Econ. 2004, 13: 1203-1210. 10.1002/hec.901.PubMedCrossRef Richardson G, Manca A: Calculation of quality adjusted life years in the published literature: a review of methodology and transparency. Health Econ. 2004, 13: 1203-1210. 10.1002/hec.901.PubMedCrossRef
11.
go back to reference Stalmeier PF, Goldstein MK, Holmes AM, Lenert L, Miyamoto J, Stiggelbout AM, Torrance GW, Tsevat J: What should be reported in a methods section on utility assessment?. Med Decis Making. 2001, 21: 200-207. 10.1177/02729890122062497.PubMedCrossRef Stalmeier PF, Goldstein MK, Holmes AM, Lenert L, Miyamoto J, Stiggelbout AM, Torrance GW, Tsevat J: What should be reported in a methods section on utility assessment?. Med Decis Making. 2001, 21: 200-207. 10.1177/02729890122062497.PubMedCrossRef
12.
go back to reference Stata Corp: Stata Statistical Software: Release 9.0. 2005, College Station, TX: Stata Corporation Stata Corp: Stata Statistical Software: Release 9.0. 2005, College Station, TX: Stata Corporation
13.
go back to reference Landis JR, Koch GG: The measurement of observer agreement for categorical data. Biometrics. 1977, 33: 159-174. 10.2307/2529310.CrossRef Landis JR, Koch GG: The measurement of observer agreement for categorical data. Biometrics. 1977, 33: 159-174. 10.2307/2529310.CrossRef
14.
go back to reference Brazier J, Roberts J, Deverill M: The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002, 21: 271-292. 10.1016/S0167-6296(01)00130-8.PubMedCrossRef Brazier J, Roberts J, Deverill M: The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002, 21: 271-292. 10.1016/S0167-6296(01)00130-8.PubMedCrossRef
15.
go back to reference Sharma S, Brown GC, Brown MM, Shah GK, Snow K, Brown H, Hollands H: Converting visual acuity to utilities. Can J Ophthalmol. 2000, 35: 267-272.PubMedCrossRef Sharma S, Brown GC, Brown MM, Shah GK, Snow K, Brown H, Hollands H: Converting visual acuity to utilities. Can J Ophthalmol. 2000, 35: 267-272.PubMedCrossRef
16.
go back to reference Torrance GW, Feeny DH, Furlong WJ, Barr RD, Zhang Y, Wang Q: Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care. 1996, 34: 702-722. 10.1097/00005650-199607000-00004.PubMedCrossRef Torrance GW, Feeny DH, Furlong WJ, Barr RD, Zhang Y, Wang Q: Multiattribute utility function for a comprehensive health status classification system. Health Utilities Index Mark 2. Med Care. 1996, 34: 702-722. 10.1097/00005650-199607000-00004.PubMedCrossRef
17.
go back to reference Garcia-Altes A: Twenty years of health care economic analysis in Spain: are we doing well?. Health Econ. 2001, 10: 715-729. 10.1002/hec.608.PubMedCrossRef Garcia-Altes A: Twenty years of health care economic analysis in Spain: are we doing well?. Health Econ. 2001, 10: 715-729. 10.1002/hec.608.PubMedCrossRef
18.
go back to reference Siegel JE, Byron SC, Lawrence WF: Federal Sponsorship of Cost-Effectiveness and Related Research in Health Care: 1997–2001. Value Health. 2005, 8: 223-236. 10.1111/j.1524-4733.2005.04037.x.PubMedCrossRef Siegel JE, Byron SC, Lawrence WF: Federal Sponsorship of Cost-Effectiveness and Related Research in Health Care: 1997–2001. Value Health. 2005, 8: 223-236. 10.1111/j.1524-4733.2005.04037.x.PubMedCrossRef
19.
go back to reference Neumann PJ, Rosen AB, Greenberg D, Olchanski NV, Pande R, Chapman RH, Stone PW, Ondategui-Parra S, Nadai J, Siegel JE, et al: Can we better prioritize resources for cost-utility research?. Med Decis Making. 2005, 25: 429-436. 10.1177/0272989X05276853.PubMedCrossRef Neumann PJ, Rosen AB, Greenberg D, Olchanski NV, Pande R, Chapman RH, Stone PW, Ondategui-Parra S, Nadai J, Siegel JE, et al: Can we better prioritize resources for cost-utility research?. Med Decis Making. 2005, 25: 429-436. 10.1177/0272989X05276853.PubMedCrossRef
20.
go back to reference Lexchin J, Bero LA, Djulbegovic B, Clark O: Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ. 2003, 326: 1167-1170. 10.1136/bmj.326.7400.1167.PubMedPubMedCentralCrossRef Lexchin J, Bero LA, Djulbegovic B, Clark O: Pharmaceutical industry sponsorship and research outcome and quality: systematic review. BMJ. 2003, 326: 1167-1170. 10.1136/bmj.326.7400.1167.PubMedPubMedCentralCrossRef
21.
go back to reference Friedberg M, Saffran B, Stinson TJ, Nelson W, Bennett CL: Evaluation of conflict of interest in economic analyses of new drugs used in oncology. JAMA. 1999, 282: 1453-1457. 10.1001/jama.282.15.1453.PubMedCrossRef Friedberg M, Saffran B, Stinson TJ, Nelson W, Bennett CL: Evaluation of conflict of interest in economic analyses of new drugs used in oncology. JAMA. 1999, 282: 1453-1457. 10.1001/jama.282.15.1453.PubMedCrossRef
22.
go back to reference Baker CB, Johnsrud MT, Crismon ML, Rosenheck RA, Woods SW: Quantitative analysis of sponsorship bias in economic studies of antidepressants. Br J Psychiatry. 2003, 183: 498-506. 10.1192/bjp.183.6.498.PubMedCrossRef Baker CB, Johnsrud MT, Crismon ML, Rosenheck RA, Woods SW: Quantitative analysis of sponsorship bias in economic studies of antidepressants. Br J Psychiatry. 2003, 183: 498-506. 10.1192/bjp.183.6.498.PubMedCrossRef
23.
go back to reference Schwappach DL, Koeck CM: Selective COX-2 inhibitors: a health economic perspective. Wien Med Wochenschr. 2003, 153: 116-122. 10.1046/j.1563-258X.2003.03006.x.PubMedCrossRef Schwappach DL, Koeck CM: Selective COX-2 inhibitors: a health economic perspective. Wien Med Wochenschr. 2003, 153: 116-122. 10.1046/j.1563-258X.2003.03006.x.PubMedCrossRef
24.
go back to reference Knox KS, Adams JR, Djulbegovic B, Stinson TJ, Tomor C, Bennet CL: Reporting and dissemination of industry versus non-profit sponsored economic analyses of six novel drugs used in oncology. Ann Oncol. 2000, 11: 1591-1595. 10.1023/A:1008309817708.PubMedCrossRef Knox KS, Adams JR, Djulbegovic B, Stinson TJ, Tomor C, Bennet CL: Reporting and dissemination of industry versus non-profit sponsored economic analyses of six novel drugs used in oncology. Ann Oncol. 2000, 11: 1591-1595. 10.1023/A:1008309817708.PubMedCrossRef
25.
go back to reference Bell CM, Urbach DR, Ray JG, Bayoumi A, Rosen AB, Greenberg D, Neumann PJ: Bias in published cost effectiveness studies: systematic review. BMJ. 2006, 332: 699-703. 10.1136/bmj.38737.607558.80.PubMedPubMedCentralCrossRef Bell CM, Urbach DR, Ray JG, Bayoumi A, Rosen AB, Greenberg D, Neumann PJ: Bias in published cost effectiveness studies: systematic review. BMJ. 2006, 332: 699-703. 10.1136/bmj.38737.607558.80.PubMedPubMedCentralCrossRef
26.
go back to reference Pritchard C: Developments in economic evaluation in health care: A review of HEED. 2004, London: Office of Health Economics (OHE) Pritchard C: Developments in economic evaluation in health care: A review of HEED. 2004, London: Office of Health Economics (OHE)
27.
go back to reference Griebsch I, Coast J, Brown J: Quality-adjusted life-years lack quality in pediatric care: a critical review of published cost-utility studies in child health. Pediatrics. 2005, 115: e600-e614. 10.1542/peds.2004-2127.PubMedCrossRef Griebsch I, Coast J, Brown J: Quality-adjusted life-years lack quality in pediatric care: a critical review of published cost-utility studies in child health. Pediatrics. 2005, 115: e600-e614. 10.1542/peds.2004-2127.PubMedCrossRef
28.
go back to reference Neumann PJ, Stone PW, Chapman RH, Sandberg EA, Bell CM: The quality of published cost-utility analyses, 1976–1997. Ann Intern Med. 2000, 132: 964-972.PubMedCrossRef Neumann PJ, Stone PW, Chapman RH, Sandberg EA, Bell CM: The quality of published cost-utility analyses, 1976–1997. Ann Intern Med. 2000, 132: 964-972.PubMedCrossRef
29.
go back to reference Neumann PJ, Zinner DE, Wright JC: Are Methods for estimating QALYs in cost-effectiveness analyses improving?. Med Decis Making. 1997, 17: 402-408.PubMedCrossRef Neumann PJ, Zinner DE, Wright JC: Are Methods for estimating QALYs in cost-effectiveness analyses improving?. Med Decis Making. 1997, 17: 402-408.PubMedCrossRef
30.
go back to reference Gerard K, Smoker I, Seymour J: Raising the quality of cost-utility analyses: lessons learnt and still to learn. Health Policy. 1999, 46: 217-238. 10.1016/S0168-8510(98)00061-X.PubMedCrossRef Gerard K, Smoker I, Seymour J: Raising the quality of cost-utility analyses: lessons learnt and still to learn. Health Policy. 1999, 46: 217-238. 10.1016/S0168-8510(98)00061-X.PubMedCrossRef
31.
go back to reference Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM: Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2004 Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM: Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2004
32.
go back to reference Badia X, Roset M, Herdman M, Kind P: A comparison of United Kingdom and Spanish general population time trade-off values for EQ-5D health states. Med Decis Making. 2001, 21: 7-16.PubMedCrossRef Badia X, Roset M, Herdman M, Kind P: A comparison of United Kingdom and Spanish general population time trade-off values for EQ-5D health states. Med Decis Making. 2001, 21: 7-16.PubMedCrossRef
33.
go back to reference Johnson JA, Ohinmaa A, Murti B, Sintonen H, Coons SJ: Comparison of Finnish and U.S.-based visual analog scale valuations of the EQ-5D measure. Med Decis Making. 2000, 20: 281-289.PubMedCrossRef Johnson JA, Ohinmaa A, Murti B, Sintonen H, Coons SJ: Comparison of Finnish and U.S.-based visual analog scale valuations of the EQ-5D measure. Med Decis Making. 2000, 20: 281-289.PubMedCrossRef
34.
go back to reference Tsuchiya A, Ikeda S, Ikegami N, Nishimura S, Sakai I, Fukuda T, Hamashima C, Hisashige A, Tamura M: Estimating an EQ-5D population value set: the case of Japan. Health Econ. 2002, 11: 341-353. 10.1002/hec.673.PubMedCrossRef Tsuchiya A, Ikeda S, Ikegami N, Nishimura S, Sakai I, Fukuda T, Hamashima C, Hisashige A, Tamura M: Estimating an EQ-5D population value set: the case of Japan. Health Econ. 2002, 11: 341-353. 10.1002/hec.673.PubMedCrossRef
35.
go back to reference Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM: Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2004 Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM: Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2004
36.
go back to reference Dolan P: Modeling valuations for EuroQol health states. Med Care. 1997, 35: 1095-1108. 10.1097/00005650-199711000-00002.PubMedCrossRef Dolan P: Modeling valuations for EuroQol health states. Med Care. 1997, 35: 1095-1108. 10.1097/00005650-199711000-00002.PubMedCrossRef
37.
go back to reference Greiner W, Weijnen T, Nieuwenhuizen M, Oppe S, Badia X, Busschbach J, Buxton M, Dolan P, Kind P, Krabbe P, et al: A single European currency for EQ-5D health states. Results from a six-country study. Eur J Health Econ. 2003, 4: 222-231. 10.1007/s10198-003-0182-5.PubMedCrossRef Greiner W, Weijnen T, Nieuwenhuizen M, Oppe S, Badia X, Busschbach J, Buxton M, Dolan P, Kind P, Krabbe P, et al: A single European currency for EQ-5D health states. Results from a six-country study. Eur J Health Econ. 2003, 4: 222-231. 10.1007/s10198-003-0182-5.PubMedCrossRef
38.
go back to reference Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM: Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2005, 6: 124-130. 10.1007/s10198-004-0264-z.PubMedCrossRef Greiner W, Claes C, Busschbach JJ, Graf von der Schulenburg JM: Validating the EQ-5D with time trade off for the German population. Eur J Health Econ. 2005, 6: 124-130. 10.1007/s10198-004-0264-z.PubMedCrossRef
39.
go back to reference Brauer CA, Rosen AB, Greenberg D, Neumann PJ: Trends in the Measurement of Health Utilities in Published Cost-Utility Analyses. Value Health. 2006, 9: 213-218. 10.1111/j.1524-4733.2006.00116.x.PubMedCrossRef Brauer CA, Rosen AB, Greenberg D, Neumann PJ: Trends in the Measurement of Health Utilities in Published Cost-Utility Analyses. Value Health. 2006, 9: 213-218. 10.1111/j.1524-4733.2006.00116.x.PubMedCrossRef
40.
go back to reference Sonnad SS, Greenberg D, Rosen AB, Neumann PJ: Diffusion of published cost-utility analyses in the field of health policy and practice. Int J Technol Assess Health Care. 2005, 21: 399-402.PubMedCrossRef Sonnad SS, Greenberg D, Rosen AB, Neumann PJ: Diffusion of published cost-utility analyses in the field of health policy and practice. Int J Technol Assess Health Care. 2005, 21: 399-402.PubMedCrossRef
41.
go back to reference Greenberg D, Pliskin JS: Preference-based outcome measures in cost-utility analyses. A 20-year overview. Int J Technol Assess Health Care. 2002, 18: 461-466.PubMed Greenberg D, Pliskin JS: Preference-based outcome measures in cost-utility analyses. A 20-year overview. Int J Technol Assess Health Care. 2002, 18: 461-466.PubMed
42.
go back to reference de Pouvourville G, Ulmann P, Nixon J, Boulenger S, Glanville J, Drummond M: The Diffusion of Health Economics Knowledge in Europe : The EURONHEED (European Network of Health Economics Evaluation Database) Project. Pharmacoeconomics. 2005, 23: 113-120. 10.2165/00019053-200523020-00003.PubMedCrossRef de Pouvourville G, Ulmann P, Nixon J, Boulenger S, Glanville J, Drummond M: The Diffusion of Health Economics Knowledge in Europe : The EURONHEED (European Network of Health Economics Evaluation Database) Project. Pharmacoeconomics. 2005, 23: 113-120. 10.2165/00019053-200523020-00003.PubMedCrossRef
43.
go back to reference Nixon J, Ulmann P, Glanville J, Boulenger S, Drummond M, de PG: The European Network of Health Economic Evaluation Databases (EURO NHEED) Project. Eur J Health Econ. 2004, 5: 183-187.PubMedCrossRef Nixon J, Ulmann P, Glanville J, Boulenger S, Drummond M, de PG: The European Network of Health Economic Evaluation Databases (EURO NHEED) Project. Eur J Health Econ. 2004, 5: 183-187.PubMedCrossRef
Metadata
Title
HEE-GER: a systematic review of German economic evaluations of health care published 1990–2004
Authors
David LB Schwappach
Till A Boluarte
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2007
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/1472-6963-7-7

Other articles of this Issue 1/2007

BMC Health Services Research 1/2007 Go to the issue