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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2011

Open Access 01-12-2011 | Research

Heath-related quality of life in thyroid cancer patients following radioiodine ablation

Authors: David Taïeb, Karine Baumstarck-Barrau, Frédéric Sebag, Cécile Fortanier, Catherine De Micco, Anderson Loundou, Pascal Auquier, Fausto F Palazzo, Jean-françois Henry, Olivier Mundler

Published in: Health and Quality of Life Outcomes | Issue 1/2011

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Abstract

Background

There is limited information about the medium to long-term health-related quality of life (QOL) in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the determinants of medium-term QOL after the initial therapy.

Methods

Following a total thyroidectomy, 88 thyroid cancer patients received either rhTSH or hypothyroid-assisted radioiodine ablation (RRA) using 3.7 GBq (100 mCi) of radioiodine. QOL evaluation of the patients using the validated Functional Assessment of Chronic Illness & Therapy (FACIT) was performed at the time of inclusion (t0) and later at the 9-month post-RRA (t1).

Results

83 patients were eligible for the final evaluation. Medium-term FACIT scores were not statistically different between t0 and t1 patients. All but one domain of the QOL score was similar between t0 and t1. Using a multivariate analysis, only age and immediate postoperative QOL scores were found to be determinants of the overall medium term 9-month QOL scores. Analysis showed that 'high QOL levels' (baseline and 9-month) and 'no depression', 'low anxiety levels', were associated with '<45yrs', 'men', 'partner', and 'rhTSH stimulation'.

Conclusions

The use of radioiodine ablation does not seem to affect the medium term QOL scores of patients. Medium-term QOL is mainly determined by pre-ablation QOL. The assessment of baseline QOL might be interesting to evaluate in order to adapt the treatment protocols, the preventive strategies, and medical information to patients for potentially improving their outcomes.
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Metadata
Title
Heath-related quality of life in thyroid cancer patients following radioiodine ablation
Authors
David Taïeb
Karine Baumstarck-Barrau
Frédéric Sebag
Cécile Fortanier
Catherine De Micco
Anderson Loundou
Pascal Auquier
Fausto F Palazzo
Jean-françois Henry
Olivier Mundler
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2011
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-9-33

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