Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 8/2020

01-08-2020 | Heart Transplantation | Cardiac

Cardiovascular magnetic resonance–derived myocardial strain in asymptomatic heart transplanted patients and its correlation with late gadolinium enhancement

Authors: Xuehua Shen, Yating Yuan, Ming Yang, Jing Wang, Wei Sun, Mingxing Xie, Li Zhang, Xiaoyue Zhou, Bo Liang

Published in: European Radiology | Issue 8/2020

Login to get access

Abstract

Objectives

To investigate whether cardiovascular magnetic resonance (CMR)–derived myocardial strains were abnormal in asymptomatic heart transplant (HT) patients with normal left ventricular ejection fraction (LVEF) and to detect the relationship between CMR-derived myocardial strain parameters and late gadolinium enhancement (LGE) in asymptomatic HT patients.

Methods

A total of 72 HT patients and 35 healthy volunteers underwent 1.5-T MR scanning. The examination protocol included basic cine imaging and LGE. The deformation registration algorithm (DRA) and feature tracking (FT) software were used for the strain analyses. Myocardial strain measurements included left ventricular global longitudinal strain (LVGLS), LV global circumferential strain (LVGCS), LV global radial strain (LVGRS) and right ventricular longitudinal strain (RVLS).

Results

Compared with healthy volunteers, HT patients had significantly decreased DRA- and FT- derived myocardial strain measurements (all p < 0.05). There was a significant correlation and high reproducibility between the DRA- and FT-derived strain parameters. Both CMR-derived LVGLS and LVGRS were significantly related to the presence of LGE, and multivariate logistic regression analyses showed that the LVGLS measurement obtained from both techniques was independently associated with the presence of LGE. The odds ratios (ORs) for DRA- and FT-LVGLS were 1.340 and 1.342, respectively.

Conclusions

Asymptomatic HT patients with preserved LVEF exhibited reduced myocardial strain parameters. The CMR-derived LVGLS was independently related to the presence of LGE in HT patients.

Key Points

• Reduced myocardial strain parameters were found in asymptomatic heart transplanted (HT) patients with normal left ventricular ejection fraction (LVEF).
• The deformation registration algorithm (DRA) and feature tracking (FT)–derived strains in asymptomatic HT patients had high reproducibility.
• DRA- and FT-derived LVGLS had an independent relationship with late gadolinium enhancement (LGE) in asymptomatic HT patients.
Literature
1.
Stewart S, Winters GL, Fishbein MC et al (2005) Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 24:1710–1720CrossRef
2.
Mehra MR, Crespo-Leiro MG, Dipchand A et al (2010) International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant 29:717–727CrossRef
3.
Daly KP, Marshall AC, Vincent JA et al (2012) Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant 31:398–409CrossRef
4.
Pophal SG, Sigfusson G, Booth KL et al (1999) Complications of endomyocardial biopsy in children. J Am Coll Cardiol 34:2105–2110CrossRef
5.
Badano LP, Miglioranza MH, Edvardsen T et al (2015) European Association of Cardiovascular Imaging/Cardiovascular Imaging Department of the Brazilian Society of Cardiology recommendations for the use of cardiac imaging to assess and follow patients after heart transplantation. Eur Heart J Cardiovasc Imaging 16:919–948CrossRef
6.
Clemmensen TS, Eiskjr H, Logstrup BB, Ilkjr LB, Poulsen SH (2017) Left ventricular global longitudinal strain predicts major adverse cardiac events and all-cause mortality in heart transplant patients. J Heart Lung Transplant 36:567–576CrossRef
7.
Clemmensen TS, Logstrup BB, Eiskjaer H, Poulsen SH (2015) Evaluation of longitudinal myocardial deformation by 2-dimensional speckle-tracking echocardiography in heart transplant recipients: relation to coronary allograft vasculopathy. J Heart Lung Transplant 34:195–203CrossRef
8.
Kobayashi Y, Kobayashi Y, Yang H-M et al (2018) Long-term prognostic value of invasive and non-invasive measures early after heart transplantation. Int J Cardiol 260:31–35CrossRef
9.
Hernandez LE, Chrisant MK, Valdes-Cruz LM (2019) Global left ventricular relaxation: a useful echocardiographic marker of heart transplant rejection and recovery in children. J Am Soc Echocardiogr 32:529–536CrossRef
10.
Dandel M, Hetzer R (2017) Post-transplant surveillance for acute rejection and allograft vasculopathy by echocardiography: usefulness of myocardial velocity and deformation imaging. J Heart Lung Transplant 36:117–131CrossRef
11.
Clemmensen TS, Logstrup BB, Eiskjaer H, Poulsen SH (2016) Serial changes in longitudinal graft function and implications of acute cellular graft rejections during the first year after heart transplantation. Eur Heart J Cardiovasc Imaging 17:184–193CrossRef
12.
Sade LE, Hazirolan T, Kozan H et al (2018) T1 mapping by cardiac magnetic resonance and multidimensional speckle-tracking strain by echocardiography for the detection of acute cellular rejection in cardiac allograft recipients. JACC Cardiovasc Imaging 12:1601–1614CrossRef
13.
Clemmensen TS, Eiskjaer H, Logstrup BB et al (2016) Noninvasive detection of cardiac allograft vasculopathy by stress exercise echocardiographic assessment of myocardial deformation. J Am Soc Echocardiogr 29:480–490CrossRef
14.
Erbel C, Mukhammadaminova N, Gleissner CA et al (2016) Myocardial perfusion reserve and strain-encoded CMR for evaluation of cardiac allograft microvasculopathy. JACC Cardiovasc Imaging 9:255–266CrossRef
15.
Shenoy C, Romano S, Hughes A et al (2019) Abstract 15299: prognostic value of cardiovascular magnetic resonance feature-tracking global longitudinal strain in heart transplant recipients. Circulation 140:A15299–A15299
16.
Medvedofsky D, Maffessanti F, Weinert L et al (2018) 2D and 3D echocardiography-derived indices of left ventricular function and shape relationship with mortality. JACC Cardiovasc Imaging 11:1569–1579CrossRef
17.
Jeung M-Y, Germain P, Croisille P, El Ghannudi S, Roy C, Gangi A (2012) Myocardial tagging with MR imaging: overview of normal and pathologic findings. Radiographics 32:1381–1398CrossRef
18.
Hor KN, Gottliebson WM, Carson C et al (2010) Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging 3:144–151CrossRef
19.
Augustine D, Lewandowski AJ, Lazdam M et al (2013) Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender. J Cardiovasc Magn Reson. https://​doi.​org/​10.​1186/​1532-429X-15-8
20.
Lamacie MM, Thavendiranathan P, Hanneman K et al (2017) Quantification of global myocardial function by cine MRI deformable registration-based analysis: comparison with MR feature tracking and speckle-tracking echocardiography. Eur Radiol 27:1404–1415CrossRef
21.
22.
Altiok E, Neizel M, Tiemann S et al (2013) Layer-specific analysis of myocardial deformation for assessment of infarct transmurality: comparison of strain-encoded cardiovascular magnetic resonance with 2D speckle tracking echocardiography. Eur Heart J Cardiovasc Imaging 14:570–578CrossRef
23.
Altiok E, Tiemann S, Becker M et al (2014) Myocardial deformation imaging by two-dimensional speckle-tracking echocardiography for prediction of global and segmental functional changes after acute myocardial infarction: a comparison with late gadolinium enhancement cardiac magnetic resonance. J Am Soc Echocardiogr 27:249–257CrossRef
24.
25.
Shanbhag SM, Greve AM, Aspelund T et al (2019) Prevalence and prognosis of ischaemic and non-ischaemicmyocardial fibrosis in older adults. Eur Heart J 40:529–538CrossRef
26.
27.
Winters GL, Costanzo-Nordin MR (1991) Pathological findings in 2300 consecutive endomyocardial biopsies. Mod Pathol 4:441–448PubMed
28.
Gramley F, Lorenzen J, Pezzella F et al (2009) Hypoxia and myocardial remodeling in human cardiac allografts: a time-course study. J Heart Lung Transplant 28:1119–1126CrossRef
29.
Cerqueira MD, Weissman NJ, Dilsizian V et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart - a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105:539–542CrossRef
30.
Beliveau P, Cheriet F, Anderson SA, Taylor JL, Arai AE, Hsu L-Y (2015) Quantitative assessment of myocardial fibrosis in an age-related rat model by ex vivo late gadolinium enhancement magnetic resonance imaging with histopathological correlation. Comput Biol Med 65:103–113CrossRef
31.
Braggion-Santos MF, Andre F, Lossnitzer D et al (2014) Prevalence of different forms of infarct-atypical late gadolinium enhancement in patients early and late after heart transplantation. Clin Res Cardiol 103:57–63CrossRef
32.
Saleh HK, Villarraga HR, Kane GC et al (2011) Normal left ventricular mechanical function and synchrony values by speckle-tracking echocardiography in the transplanted heart with normal ejection fraction. J Heart Lung Transplant 30:652–658CrossRef
33.
Latus H, Hachmann P, Voges I et al (2019) Reduced biventricular volumes and myocardial dysfunction long-term after pediatric heart transplantation assessed by CMR. Transplantation 103:2682–2691CrossRef
34.
Chinali M, Esposito C, Grutter G et al (2017) Cardiac dysfunction in children and young adults with heart transplantation: a comprehensive echocardiography study. J Heart Lung Transplant 36:559–566CrossRef
35.
Miller CA, Naish JH, Shaw SM et al (2014) Multiparametric cardiovascular magnetic resonance surveillance of acute cardiac allograft rejection and characterisation of transplantation-associated myocardial injury: a pilot study. J Cardiovasc Magn Reson. https://​doi.​org/​10.​1186/​s12968-014-0052-6
36.
Vo HQ, Marwick TH, Negishi K (2018) MRI-derived myocardial strain measures in normal subjects. JACC Cardiovasc Imaging 11:196–205CrossRef
37.
38.
Fyfe DA, Ketchum D, Lewis R et al (2006) Tissue Doppler imaging detects severely abnormal myocardial velocities that identify children with pre-terminal cardiac graft failure after heart transplantation. J Heart Lung Transplant 25:510–517CrossRef
39.
Costanzo MR, Dipchand A, Starling R et al (2010) The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant 29:914–956CrossRef
40.
41.
42.
Narang A, Blair JE, Patel MB et al (2018) Myocardial perfusion reserve and global longitudinal strain as potential markers of coronary allograft vasculopathy in late-stage orthotopic heart transplantation. Int J Cardiovasc Imaging 34:1607–1617CrossRef
43.
Pedrotti P, Vittori C, Facchetti R et al (2017) Prognostic impact of late gadolinium enhancement in the risk stratification of heart transplant patients. Eur Heart J Cardiovasc Imaging 18:130–137CrossRef
44.
Hughes A, Okasha O, Farzaneh-Far A et al (2019) Myocardial fibrosis and prognosis in heart transplant recipients. Circ Cardiovasc Imaging 12:e009060–e009060CrossRef
45.
46.
Metadata
Title
Cardiovascular magnetic resonance–derived myocardial strain in asymptomatic heart transplanted patients and its correlation with late gadolinium enhancement
Authors
Xuehua Shen
Yating Yuan
Ming Yang
Jing Wang
Wei Sun
Mingxing Xie
Li Zhang
Xiaoyue Zhou
Bo Liang
Publication date
01-08-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-020-06763-3

Other articles of this Issue 8/2020

European Radiology 8/2020 Go to the issue

Nuclear Medicine

Baseline 18F-FDG PET radiomic features as predictors of 2-year event-free survival in diffuse large B cell lymphomas treated with immunochemotherapy

Correction

Correction to: CT compared to MRI for functional evaluation of the right ventricle: a systematic review and meta-analysis

Urogenital

Integration of proteomics with CT-based qualitative and radiomic features in high-grade serous ovarian cancer patients: an exploratory analysis

Cardiac

Pressure-flow curve derived from coronary CT angiography for detection of significant hemodynamic stenosis

Chest

CT features of novel coronavirus pneumonia (COVID-19) in children

Emergency Radiology

Diagnostic accuracy of the Ottawa Knee Rule in adult acute knee injuries: a systematic review and meta-analysis