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Journal of Cardiothoracic Surgery

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Open Access 01-12-2021 | Heart Surgery | Research article

Association between glucose variability and postoperative delirium in acute aortic dissection patients: an observational study

Authors: Yan-Juan Lin, Ling-Yu Lin, Yan-Chun Peng, Hao-Ruo Zhang, Liang-wan Chen, Xi-Zhen Huang, Qiong Chen

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

Blood glucose variability is associated with poor prognosis after cardiac surgery, but the relationship between glucose variability and postoperative delirium in patients with acute aortic dissection is unclear. The study aims to investigate the association of blood glucose variability with postoperative delirium in acute aortic dissection patients.

Methods

We prospectively analyzed 257 patients including 103 patients with delirium. The patients were divided into two groups according to whether delirium was present. The outcome measures were postoperative delirium, the length of the Intensive Care Unit stay, and the duration of hospital stay. Multivariable Cox competing risk survival models was used to assess.

Results

A total of 257 subjects were enrolled, including 103 patients with delirium. There were statistically significant differences between the two groups in body mass index, history of cardiac surgery, first admission blood glucose, white blood cell counts, Acute Physiology and Chronic Health Evaluation II score, hypoxemia, mechanical ventilation duration, and the length of Intensive Care Unit stay(P < 0.05). The delirium group exhibited significantly higher values of the mean of blood glucose (MBG) and the standard deviation of blood glucose (SDBG) than in the non-delirium group(P < 0.05). In model 1, the adjusted hazard ratio (AHR) of the standard deviation of blood glucose was 1.436(P < 0.05). In Model 2, the standard deviation of blood glucose (AHR = 1.418, 95%CI = 1.195–1.681, P < 0.05) remained significant after adjusting for confounders. The area under the curve of the SDBG was 0.763(95%CI = 0.704–0.821, P < 0.01). The sensitivity was 81.6%, and the specificity was 57.8%.

Conclusions

Glucose variability is associated with the risk of delirium in patients after aortic dissection surgery, and high glycemic variability increases the risk of postoperative delirium.

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Title: Association between glucose variability and postoperative delirium in acute aortic dissection patients: an observational study
Authors: Yan-Juan Lin
Ling-Yu Lin
Yan-Chun Peng
Hao-Ruo Zhang
Liang-wan Chen
Xi-Zhen Huang
Qiong Chen
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Heart Surgery
Heart Surgery
Aortic Dissection
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01456-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between glucose variability and postoperative delirium in acute aortic dissection patients: an observational study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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