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BMC Anesthesiology
Published in: BMC Anesthesiology 1/2023

Open Access 01-12-2023 | Heart Surgery | Study Protocol

Postoperative glucocorticoids in patients with acute type A aortic dissection (GLAD): study protocol for a prospective, single-center, randomized controlled trial

Authors: Yi-zhi Deng, Ming-hao Luo, Jing-chao Luo, Jia-kun Li, Jia-qi Chen, Yi-jie Zhang, Jun-yi Hou, Ying Su, Guo-wei Tu, Zhe Luo

Published in: BMC Anesthesiology | Issue 1/2023

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Abstract

Background

Patients receiving surgical treatment of acute type A Aortic Dissection (aTAAD) are common to suffer organ dysfunction in the intensive care unit due to overwhelming inflammation. Previous studies have revealed that glucocorticoids may reduce complications in certain patient groups, but evidence between postoperative glucocorticoids administration and improvement in organ dysfunction after aTAAD surgery are lacking.

Methods

This study will be an investigator-initiated, prospective, single-blind, randomized, single-center study. Subjects with confirmed diagnosis of aTAAD undergoing surgical treatment will be enrolled and 1:1 randomly assigned to receive either glucocorticoids or normal treatment. All patients in the glucocorticoids group will be given methylprednisolone intravenously for 3 days after enrollment. The primary endpoint will be the amplitude of variation of Sequential Organ Failure Assessment score on post-operative day 4 compared to baseline.

Discussion

The trial will explore the rationale for postoperative application of glucocorticoids in patients after aTAAD surgery.

Trial registration

This study has been registered on ClinicalTrials.gov (NCT04734418).
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Metadata
Title
Postoperative glucocorticoids in patients with acute type A aortic dissection (GLAD): study protocol for a prospective, single-center, randomized controlled trial
Authors
Yi-zhi Deng
Ming-hao Luo
Jing-chao Luo
Jia-kun Li
Jia-qi Chen
Yi-jie Zhang
Jun-yi Hou
Ying Su
Guo-wei Tu
Zhe Luo
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2023
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-023-02124-x

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