Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 6/2017

01-06-2017 | Review Article

Hearing loss in vitiligo: current concepts and review

Authors: Marrigje Aagje de Jong, Cahtia Adelman, Menachem Gross

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2017

Login to get access

Abstract

The objective of this study was to describe the occurrence, clinical manifestations, audiometric findings, pathogenesis and approach to sensorineural hearing loss (SNHL) among patients diagnosed with vitiligo with a review of the literature. We present a systematic review of the literature on cases of SNHL in patients diagnosed with vitiligo and studies conducted to investigate audiometric changes in such patients. Data on presentation, diagnosis and medical approach were reviewed. A total of 21 studies and case reports revealed at least 102 cases of SNHL in patients diagnosed with vitiligo. Arguments for a common causative etiology related to melanocyte function were mentioned in most of the literature. Evaluation of hearing function among all patients diagnosed with vitiligo seems to be an accepted approach; it should include audiometry, otoacoustic emissions (OAE) and ABR measurements. Extra precaution to prevent ototoxic or noise-induced hearing loss is strongly recommended. Further research is needed to better understand its pathogenesis.
Literature
1.
2.
3.
Song YH, Connor E, Li Y, Zorovich B, Balducci P et al. (1994) The role of tyrosinase in autoimmune vitiligo. Lancet 15;344(8929):1049–1052CrossRefPubMed
4.
Halder RM, Taliaferro SJ (2008) Vitiligo; in Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller A, Lefell D (eds) Fitzpatrick’s dermatology in general medicine. McGraw-Hill, New York, pp 616–622
5.
6.
Savin MSC (1965) The blood vessels and pigmentary cells of the inner ear. Ann Otol Rhinol Laryngol 74:611–623 (reference only) CrossRefPubMed
7.
Steel KP, Barkway C (1989) Another role for melanocytes: their importance for normal stria vascularis development in the mammalian inner ear. Development 107:453–463PubMed
8.
Cable J, Jackson IJ, Steel KP (1993) Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function in the mouse inner ear. Pigment Cell Res 6:215–225 (abstract only) CrossRefPubMed
9.
10.
Araki S, Mizuta K, Takeshita T, Morita H, Mineta H et al (2002) Degeneration of the stria vascularis during development in melanocytes deficient mutant rats (Ws/Ws rats). Eur Arch Otorhinolaryngol 259:309–315PubMed
11.
Conlee JW, Abdul-Bagi KJ, McCandless GA et al (1986) Differential susceptibility to noise-induced permanent threshold shift between albino and pigmented guinea pigs. Hear Res 23:81–91CrossRefPubMed
12.
Barrenas ML (1997) Hair cell loss from acoustic trauma in chloroquine-treated red, black and albino guinea pigs. Audiology 36(4):187–201CrossRefPubMed
13.
Carvalho S, Mom T, Gilain L, Ayan P (2004) Frequency specificity of distortion-product otoacoustic emissions produced by high-level tones despite inefficient cochlear electromechanical feedback. J Acoust Soc Am 116(3):1639–1648CrossRefPubMed
14.
Tosti A, Batdazzi F, Tosti G, Monti L (1987) Audiologic abnormalities in cases of vitiligo. J Am Acad Dermatol 17:230–233CrossRefPubMed
15.
Nikiforidis GC, Tsambaos DG, Karamitsos DS, Koutsojannis CC (1993) Abnormalities of the auditory brainstem response in vitiligo. Scand Audiol 22:97–100 (abstract only)CrossRefPubMed
16.
Ardic FN, Aktan S, Kara CO, Sanli B (1998) High-frequency hearing and reflex latency in patients with pigment disorder. Am J Otolaryngol 19:365–369CrossRefPubMed
17.
Sharma L, Bhawan R, Jain RK (2004) Hypoacusis in vitiligo. Indian J Dermatol Venereol Leprol 70:162–164PubMed
18.
Ayodogan K, Turan OF, Onart S, Karadogan SK, Tunali S (2006) Audiological abnormalities in patients with vitiligo. Clin Exp Dermatol 31:110–113CrossRef
19.
Hong CK, Lee MH, Jeong KH, Cha CI, Yeo SG (2009) Clinical analysis of hearing levels in vitiligo patients. Eur J Dermatol 19:50–56 (abstract only) PubMed
20.
Aslan S, Serarslan G, Teksoz E, Dagli S (2010) Audiological and transient evoked otoacoustic emission findings in patients with vitiligo. Otolaryngol Head Neck Surg 142:409–414CrossRefPubMed
21.
Escalante-Ugalde C, Poblano A, Montes de Oca E, Lagunes R, Saul A (1991) No evidence of hearing loss in patients with vitiligo. Arch Dermatol 127:1240CrossRefPubMed
22.
Ozuer MZ, Sahiner T, Aktan S, Sanli B, Bayramoğlu I (1998) Auditory evoked potentials in vitiligo patients. Scand Audiol 27:255–258 (abstract only) CrossRefPubMed
23.
McCabe BF (1979) Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 88(5Pt1):585–589 (abstract only) CrossRefPubMed
24.
Thurmon TF, Jackson J, Fowler CG (1976) Deafness and vitiligo. Birth Defects Orig Artic Ser 12(5):315–320 (abstract only) PubMed
25.
Kumakiri M, Kimura T, Miura Y, Tagawa Y (1982) Vitiligo with an inflammatory erythema in Vogt-Koyanagi-Harada disease: demonstration of filamentous masses and amyloid deposits. J Cutan Pathol 9(4):258–266CrossRefPubMed
26.
Dereymaeker AM, Fryns JP, Ars J, Andresescu J, van den Berghe H (1989) Retinitis pigmentosa, hearing loss and vitiligo: report of two patients. Clin Genet 35(5):387–389
27.
Nishida W, Mukai M, Sumimoto T, Hamada M, Hiwada K (1990) Vitiligo with primary hypothyroidism and hypoacusis: a case report. Jpn J Med 29(1):66–70CrossRefPubMed
28.
Cernea P, Damien C (1994) Retinitis Pigmentosa, vitiligo and deaf-mutism. Apropos of a case. J Fr Ophtalmol 17(8–9):501–503PubMed
29.
Gopal KV, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P et al (2007) Vitiligo: a part of a systemic autoimmune process. Indian J Dermatol Venereol Leprol 73(3):162–165CrossRefPubMed
30.
Fleissig E, Gross M, Ophir I, Elidan J, Bdolah-Abram T et al (2013) Risk of sensorineural hearing loss in patients with vitiligo. Audiol Neurootol 18(4):240–246CrossRefPubMed
31.
Al-Mutairi N, Al-Sebeih KH (2011) Late onset vitiligo and audiological abnormalities: is there any association? Indian J Dermatol Venereol Leprol 77(5):571–576CrossRefPubMed
32.
Angrisani RM, Azevedo MF, Pereira LD, Lopes C, Garcia MV (2009) A study on otoacoustic emissions and supression effects in patients with vitiligo. Braz J Otorhinolaryngol 75(1):111–115CrossRefPubMed
33.
Mahdi P, Rouzbahani M, Amali A, Rezaii Khiabanlu S, Kamali M (2012) Audiological manifestations in vitiligo patients. Iran J Otorhinolaryngol 24(66):35–40PubMedPubMedCentral
34.
Anbar TS, El-Badry MM, McGrath JA, Abdel-Azim ES (2015) Most individuals with either segmental or non-segmental vitiligo display evidence of bilateral cochlear dysfunction. Br J Dermatol 172(2):406–411CrossRefPubMed
35.
Sun DQ, Zhou X, Lin FR, Francis HW, Carey JP et al (2014) Racial difference in cochlear pigmentation is associated with hearing loss risk. Otol Neurotol 35(9):1509–1514CrossRefPubMed
Metadata
Title
Hearing loss in vitiligo: current concepts and review
Authors
Marrigje Aagje de Jong
Cahtia Adelman
Menachem Gross
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 6/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-017-4452-8

Other articles of this Issue 6/2017

European Archives of Oto-Rhino-Laryngology 6/2017 Go to the issue

Head and Neck

Follow-up of oral and oropharyngeal cancer using narrow-band imaging and high-definition television with rigid endoscope to obtain an early diagnosis of second primary tumors: a prospective study

Head and Neck

Relationship between response to induction chemotherapy and disease control in patients with advanced laryngeal carcinoma included in an organ preservation protocol

Otology

Balloon Eustachian Tuboplasty in children

Letter to the Editor

Assessment of the success rates of type 1 cartilage tympanoplasty in pediatric and adult patients

Head and Neck

Treatment outcome of advance staged oral cavity cancer: concurrent chemoradiotherapy compared with primary surgery

Otology

Baha implant as a hearing solution for single-sided deafness after retrosigmoid approach for the vestibular schwannoma: surgical results