Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Journal of Cancer Survivorship
Published in: Journal of Cancer Survivorship 4/2013

01-12-2013

Health-related quality of life in young men with testicular cancer: validation of the Cancer Assessment for Young Adults (CAYA)

Authors: Michael A. Hoyt, Stefan J. Cano, Christopher S. Saigal, Annette L. Stanton

Published in: Journal of Cancer Survivorship | Issue 4/2013

Login to get access

Abstract

Background

Patient-reported outcome instruments are needed to measure health-related quality of life (HRQOL) in young adults with cancer. The purpose of this project was to establish a conceptual model and measurement instrument for assessment of HRQOL in young men with testicular cancer.

Methods

Patient interviews and a literature review were used to develop a conceptual framework of biopsychosocial domains of cancer-related quality of life and an initial pool of questionnaire items. Items were piloted and refined. Revised items were administered to a sample (N = 171) of young (ages 18–29) men with testicular cancer and repeated 4 weeks later. Rasch measurement methods guided item reduction and scale construction. Traditional psychometric analyses were also performed to allow for comparison with existing measures.

Results

The conceptual framework included seven biopsychosocial domains: physical, sexual, intrapersonal, cognitive–emotional, social–relational, educational–vocational–avocational, and spiritual to form independent scales of the resulting questionnaire, the Cancer Assessment for Young Adults–Testicular (CAYA-T). Each scale fulfilled Rasch and traditional psychometric criteria (i.e., person separation index, 0.34–0.82; Cronbach’s alpha, 0.70–0.91; and an expected pattern of convergent and discriminant validity correlations).

Conclusions

The CAYA-T can be used to assess HRQOL across a comprehensive set of domains as identified by young men with cancer. It passes strict psychometric criteria and has potential as a useful research and clinical tool.

Implications for cancer survivors

The CAYA-T has potential research and clinical value for addressing inter-related aspects of HRQOL in young adult men with cancer. The measure may assist with assessing and monitoring HRQOL across a range of domains and contributing to more comprehensive assessment of biopsychosocial needs of young adults.
Appendix
Available only for authorised users
Literature
1.
Arnett JJ. Emerging adulthood: a theory of development from the late teens through the twenties. Am Psychol. 2000;55:469–80.PubMedCrossRef
2.
Zebrack BJ. Psychological, social, and behavioral issues for young adults with cancer. Cancer. 2011;117:2289–94.PubMedCrossRef
3.
ACS (American Cancer Society). Cancer facts and figures. Atlanta, GA: American Cancer Society; 2012.
4.
Huang L, Cronin KA, Johnson KA, Mariotto AB, Feuer EJ. Improved survival time: what can survival cure models tell us about population-based survival improvements in late-stage colorectal, ovarian, and testicular cancer? Cancer. 2008;112:2289–300.PubMedCrossRef
5.
Sonneveld DJ, Hoekstra HJ, van der Graaf WT, et al. Improved long term survival of patients with metastatic nonseminomatous testicular germ cell carcinoma in relation to prognostic classification systems during the cisplatin era. Cancer. 2001;91:1304–15.PubMedCrossRef
6.
Travis LB, Beard C, Allan JM, et al. Testicular cancer survivorship: research strategies and recommendations. JNCI. 2010;102:1114–30.PubMedCrossRef
7.
Kim C, McGlynn KA, McCorkle R, et al. Quality of life among testicular cancer survivors: a case–control study in the United States. Qual Life Res. 2011;20:1629–37.PubMedCrossRef
8.
Dahl AA, Mykletun A, Fossa SD. Quality of life in survivors of testicular cancer. Urol Oncol-Semin Ori. 2005;23(3):193–200.CrossRef
9.
Fleer J, Sleijfer DT, Hoekstra HJ, Tuinman MA. Objective and subjective predictors of cancer-related stress symptoms in testicular cancer survivors. Patient Educ Couns. 2006;64:142–50.PubMedCrossRef
10.
Fleer J, Hoekstra HJ, Sleijfer DT, Hoekstra-Weebers JE. Quality of life of survivors of testicular germ cell cancer: a review of the literature. Support Care Cancer. 2004;12:476–86.PubMedCrossRef
11.
Rossen PB, Pedersen AF, Zachariae R, von der Maase H. Health-related quality of life in long-term survivors of testicular cancer. J Clin Oncol. 2009;27:5993–9.PubMedCrossRef
12.
Tuinman MA, Hoekstra HJ, Fleer J, Sleijfer DT, Hoekstra-Weebers JE. Self-esteem, social support, and mental health in survivors of testicular cancer: a comparison based on relationship status. Urol Oncol-Sem Ori. 2006;24:279–86.CrossRef
13.
Vidrine DJ, Hoekstra-Weebers JE, Hoekstra HJ, Tuinman MA, Marani S, Gritz ER. The effects of testicular cancer treatment on health-related quality of life. Urology. 2010;75:636–41.PubMedCrossRef
14.
Carpentier MY, Fortenberry JD, Ott MA, Brames MJ, Einhorn LH. Perceptions of masculinity and self-image in adolescent and young adult testicular cancer survivors: implications for romantic and sexual relationships. Psycho-Oncol. 2011;20:738–45.CrossRef
15.
Rossen P, Pedersen AF, Zachariae R, von der Maase H. Sexuality and body image in long-term survivors of testicular cancer. Eur J Cancer. 2012;48:571–8.PubMedCrossRef
16.
Rudberg L, Carlsson M, Nilsson S, Wikblad K. Self-perceived physical, psychological, and general symptoms in survivors of testicular cancer: 3 to 13 years after treatment. Cancer Nurs. 2002;25:187–95.PubMedCrossRef
17.
18.
Lipscomb J, Gotay CC, Snyder C. Outcomes assessment in cancer. Cambridge, MA: Cambridge University Press; 2005.
19.
SACMOT (Scientific Advisory Committee of the Medical Outcomes Trust). Assessing health status and quality of life instruments: attributes and review criteria. Qual Life Res. 2002;11:193–205.CrossRef
20.
Cano SJ, Klassen AF, Scott AM, Cordeiro PG, Pusic AL. The BREAST-Q: further validation in independent clinical samples. Plast Reconstr Surg. 2012;129:293–302.PubMedCrossRef
21.
Pusic AL, Klassen AF, Scott AM, Klok JA, Cordeiro PG, Cano SJ. Development of a new patient-reported outcome measure for breast surgery: the BREAST-Q. Plast Reconstr Surg. 2009;124:345–53.PubMedCrossRef
22.
Ferrans CE. Definitions and conceptual models of quality of life. In: Lipscomb J, Gotay CC, Snyder C, editors. Outcomes assessment in cancer. Cambridge, UK: Cambridge University Press; 2005. p. 14–30.
23.
Cella D. Assessment methods for quality of life in cancer patients: FACIT measurement system. Int J Pharm Med. 2000;14:78–81.CrossRef
24.
EORTC (European Organization for Research and Treatment of Cancer). EORTC QLQ-C30 scoring manual. Brussels: EORTC, 2001.
25.
Peterman AH, Fitchett G, Brady MJ, Hernandez L, Cella D. Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy—spirituality well-being scale (FACT-Sp). Ann Behav Med. 2002;24:49–58.PubMedCrossRef
26.
Tomich P, Helgeson V. Is finding something good in the bad always good? Benefit-finding among women with breast cancer. Health Psychol. 2004;23:16–23.PubMedCrossRef
27.
Hoyt MA, Stanton AL, Irwin MR, Thomas KS. Cancer-related masculine threat, emotional approach coping, and physical functioning following treatment for prostate cancer. Health Psychol. 2013;32:66–74.PubMedCrossRef
28.
Cutrona CE, Russell D. The provisions of social relationships and adaptation to stress. In: Jones WH, Perlman D, editors. Advances in personal relationships, vol. 1. Greenwich, CT: JAI Press; 1987. p. 37–67.
29.
Giese-Davis J, Koopman C, Butler LD, et al. The Stanford Emotional Self-Efficacy Scale-Cancer: reliability, validity, and generalizability. In: Nyklicek I, Temoshok L, Vingergoets A, editors. Emotional expression and health: advances in theory, assessment and clinical applications. New York: Routledge; 2004. p. 204–22.
30.
Wrosch C, Scheier MF, Miller GE, Schulz R, Carver CS. Adaptive self-regulation of unattainable goals: goal disengagement, goal reengagement, and subjective well-being. Pers Soc Psychol Bull. 2003;29:1494–508.PubMedCrossRef
31.
Stewart AL, Hays RD, Ware JE. The MOS Short-Form General Health Survey: reliability and validity in a patient population. Med Care. 1988;26:724–35.PubMedCrossRef
32.
Andrich D. A rating formulation for ordered response categories. Psychometrika. 1978;43:561–73.CrossRef
33.
Andrich D. Rasch models for measurement. Beverly Hills, CA: Sage; 1988.
34.
Rasch G. Probabilistic models for some intelligence and attainment tests. Chicago, IL: The University of Chicago Press; 1980.
35.
Andrich D, Sheridan B, Luo G. RUMM 2030. Perth, Western Australia: RUMM Laboratory; 2009.
36.
Hagquist C, Andrich D. Is the Sense of Coherence-instrument applicable on adolescents? A latent trait analysis using Rasch-modelling. Pers Individ Differ. 2004;36:955–68.CrossRef
37.
Cronbach LJ. Coefficient alpha and the internal structure of tests. Psychometrika. 1951;16:297–334.CrossRef
38.
Andrich D. An index of person separation in latent trait theory, the traditional KR20 index, and the Guttman scale response pattern. Educ Psychol Res. 1982;9:95–104.
39.
DeVellis R. Scale development: theory and applications. London: Sage; 1991.
40.
McHorney CA, Tarlov AR. Individual-patient monitoring in clinical practice: are available health status surveys adequate? Qual Life Res. 1995;4:293–307.PubMedCrossRef
41.
Kaplan RM, Bush JW, Berry CC. Health status: types of validity and the index of well-being. Heal Serv Res. 1976;11:478–507.
42.
Bohrnstedt GW. Handbook of survey measurement. New York: Academic; 1983.
43.
Nunnally JC, Bernstein IH. Psychometric theory. 3rd ed. New York: McGraw-Hill; 1994.
44.
Baruch Y. Response rate in academic studies: a comparative analysis. Hum Relat. 1999;52:421–38.
45.
IOM (Institute of Medicine). Cancer care for the whole patient: meeting psychosocial needs. Board on Health Care Services. Washington, DC: The National Academic Press; 2007.
Metadata
Title
Health-related quality of life in young men with testicular cancer: validation of the Cancer Assessment for Young Adults (CAYA)
Authors
Michael A. Hoyt
Stefan J. Cano
Christopher S. Saigal
Annette L. Stanton
Publication date
01-12-2013
Publisher
Springer US
Published in
Journal of Cancer Survivorship / Issue 4/2013
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-013-0302-x

Other articles of this Issue 4/2013

Journal of Cancer Survivorship 4/2013 Go to the issue

Review

A qualitative synthesis of trials promoting physical activity behaviour change among post-treatment breast cancer survivors

OriginalPaper

Perception of body odor—an overlooked consequence of long-term gastrointestinal and urinary symptoms after radiation therapy for prostate cancer

OriginalPaper

Type of hematological malignancy is crucial for the return to work prognosis: a register-based cohort study

OriginalPaper

Health-related quality of life in survivors of childhood cancer: the role of chronic health problems

OriginalPaper

Projections of cancer prevalence by phase of care: a potential tool for planning future health service needs

OriginalPaper

Trends in modifiable lifestyle-related risk factors following diagnosis in breast cancer survivors
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits