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01-06-2019 | Original Article

Health-related quality of life associated with different symptoms in women and in men who suffer from schizophrenia

Authors: Cristina Domenech, Corrado Bernasconi, Maria Victoria Moneta, Anna-Lena Nordstroem, Paula Cristobal-Narvaez, Ellen Vorstenbosch, Jesus Cobo, Susana Ochoa, Josep Maria Haro

Published in: Archives of Women's Mental Health | Issue 3/2019

Abstract

Health-related quality of life (HRQoL) in patients with schizophrenia is related to the severity of psychiatric symptoms. The objective of this study is to analyze whether the symptoms that influence HRQoL are similar in women and men. Data were part of the Pattern study, an international observational investigation which collected data from 1379 outpatients with schizophrenia. Patients were evaluated with the Mini International Neuropsychiatric Inventory, the Clinical Global Impression-Schizophrenia, and the Positive and Negative Syndrome Scale (PANSS), and reported their quality of life using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D). Men reported higher HRQoL on all scales. PANSS total score was 80.6 (SD 23.6) for women and 77.9 (SD 22.1) for men. In women, a higher PANSS negative score and a higher PANSS affective score were associated with a lower SQLS score. In men, a higher PANSS positive score and a higher PANSS affective score were associated with a lower SQLS score. The same pattern appeared with EQ-VAS and EQ-5D tariff. In women, greater age and higher PANSS affective score were associated with a lower SF-36 mental component score. In men, higher PANSS affective, positive, and cognitive scores were associated with a lower SF-36 mental component score. This study shows that HRQoL is influenced by different psychiatric symptoms in women and men. This may have significant implications when deciding the main treatment target in patients with schizophrenia.

ClinicalTrials.gov Identifier: https://clinicaltrials.gov/ct2/show/NCT01634542

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Title: Health-related quality of life associated with different symptoms in women and in men who suffer from schizophrenia
Authors: Cristina Domenech
Corrado Bernasconi
Maria Victoria Moneta
Anna-Lena Nordstroem
Paula Cristobal-Narvaez
Ellen Vorstenbosch
Jesus Cobo
Susana Ochoa
Josep Maria Haro
Publication date: 01-06-2019
Publisher: Springer Vienna
Published in: Archives of Women's Mental Health / Issue 3/2019
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-018-0896-0

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Health-related quality of life associated with different symptoms in women and in men who suffer from schizophrenia

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