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Head and Neck Pathology
Published in: Head and Neck Pathology 2/2016

01-06-2016 | Original Paper

Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature

Authors: Valentina Lupato, Salvatore Romeo, Alessandro Franchi, Monica Mantovani, Angelo Paolo Dei Tos, Giancarlo Tirelli, Maria Cristina Da Mosto, Paolo Boscolo-Rizzo

Published in: Head and Neck Pathology | Issue 2/2016

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Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm originating from professional antigen presenting cells normally located in the T zone of the lymph node. The purpose of this report was to describe the first case of the IDCS of the submandibular gland and perform a review of the literature of head and neck IDCS. We present a case of an 81-year-old man with a 5 months history of slowly enlarging painless mass in right submandibular region. Fine needle aspiration cytology was suggestive of squamous cell carcinoma. The patient underwent surgical resection of the right submandibular gland and neck dissection. A malignant spindle cell proliferation involving the submandibular gland and colonizing one laterocervical lymph node was found. Morphology and immunophenotype prompted a differential diagnosis of a metastatic spindle cell melanoma versus an IDCS. Transmission electron microscopy was performed and supported a diagnosis of IDCS. The diagnosis of IDCS is a challenging task and may require a large array of techniques.
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Metadata
Title
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature
Authors
Valentina Lupato
Salvatore Romeo
Alessandro Franchi
Monica Mantovani
Angelo Paolo Dei Tos
Giancarlo Tirelli
Maria Cristina Da Mosto
Paolo Boscolo-Rizzo
Publication date
01-06-2016
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 2/2016
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-015-0627-z

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