Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 11/2016

01-11-2016 | Head and Neck

Head and neck cutaneous leishmania: clinical characteristics, microscopic features and molecular analysis in a cohort of 168 cases

Authors: Gabriel Dunya, Robert Habib, Roger V. Moukarbel, Ibrahim Khalifeh

Published in: European Archives of Oto-Rhino-Laryngology | Issue 11/2016

Login to get access

Abstract

Lebanon, an underendemic area for cutaneous leishmania (CL), is suffering from a CL outbreak brought by the massive population influx from endemic Syria. CL affects mainly exposed areas; therefore, the head and neck (HN) region is highly susceptible. Individuals diagnosed and speciated with CL (n = 168) using molecular and microscopic analysis on punch biopsy/scrapings were studied. Clinical data, parasitic index (PI) and Ridley’s Pattern (RP) were recorded. The HN was divided into 11 anatomic locations. Of 168 patients, 96 patients (57.1 %) had HN involvement and 72 (42.9 %) had no HN involvement. Lesions from the HN were significantly more common in younger patients and were more prone for ulceration, had larger size, higher PI and more advanced RP (p < 0.05). There was no difference in the anatomic distribution of lesions among age groups and genders in the HN group. The cheek area was the most HN involved location. Lesions were less commonly encountered in the veiled area in women. In the community we studied, HN is commonly involved by CL. Lesions with HN involvement were encountered more in pediatric age group and showed more extensive features.
Literature
1.
go back to reference Epidemiology and Risk Factors (2013) Centers for Disease Control and Prevention. Accessed 30 October 2015 Epidemiology and Risk Factors (2013) Centers for Disease Control and Prevention. Accessed 30 October 2015
2.
go back to reference Jabbour MN, Issa G, Charafeddine K, Simaan Y, Karam M, Khalifeh H, Habib R, Khalifeh I (2015) The immune microenvironment in cutaneous leishmaniasis. J Euro Acad Dermatol Venereol JEADV 29(6):1170–1179. doi:10.1111/jdv.12781 CrossRef Jabbour MN, Issa G, Charafeddine K, Simaan Y, Karam M, Khalifeh H, Habib R, Khalifeh I (2015) The immune microenvironment in cutaneous leishmaniasis. J Euro Acad Dermatol Venereol JEADV 29(6):1170–1179. doi:10.​1111/​jdv.​12781 CrossRef
6.
go back to reference Saab J, Fedda F, Khattab R, Yahya L, Loya A, Satti M, Kibbi AG, Houreih MA, Raslan W, El-Sabban M, Khalifeh I (2012) Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: a clinical, histopathological and molecular study of 57 cases. J Cutan Pathol 39(2):251–262. doi:10.1111/j.1600-0560.2011.01844.x CrossRefPubMed Saab J, Fedda F, Khattab R, Yahya L, Loya A, Satti M, Kibbi AG, Houreih MA, Raslan W, El-Sabban M, Khalifeh I (2012) Cutaneous leishmaniasis mimicking inflammatory and neoplastic processes: a clinical, histopathological and molecular study of 57 cases. J Cutan Pathol 39(2):251–262. doi:10.​1111/​j.​1600-0560.​2011.​01844.​x CrossRefPubMed
7.
go back to reference Nadim A, Faghih M (1968) The epidemiology of cutaneous leishmaniasis in the Isfahan province of Iran. I. The reservoir. II. The human disease. Trans R Soc Trop Med Hyg 62(4):534–542CrossRefPubMed Nadim A, Faghih M (1968) The epidemiology of cutaneous leishmaniasis in the Isfahan province of Iran. I. The reservoir. II. The human disease. Trans R Soc Trop Med Hyg 62(4):534–542CrossRefPubMed
8.
go back to reference Bhutto AM, Soomro RA, Nonaka S, Hashiguchi Y (2003) Detection of new endemic areas of cutaneous leishmaniasis in Pakistan: a 6-year study. Int J Dermatol 42(7):543–548CrossRefPubMed Bhutto AM, Soomro RA, Nonaka S, Hashiguchi Y (2003) Detection of new endemic areas of cutaneous leishmaniasis in Pakistan: a 6-year study. Int J Dermatol 42(7):543–548CrossRefPubMed
9.
go back to reference Talari SA, Talaei R, Shajari G, Vakili Z, Taghaviardakani A (2006) Childhood cutaneous leishmaniasis: report of 117 cases from Iran. Korean J Parasitol 44(4):355–360CrossRefPubMedPubMedCentral Talari SA, Talaei R, Shajari G, Vakili Z, Taghaviardakani A (2006) Childhood cutaneous leishmaniasis: report of 117 cases from Iran. Korean J Parasitol 44(4):355–360CrossRefPubMedPubMedCentral
10.
go back to reference Bari AU, Rahman SB (2008) Many faces of cutaneous leishmaniasis. Indian J Dermatol Venereol Leprol 74(1):23–27CrossRefPubMed Bari AU, Rahman SB (2008) Many faces of cutaneous leishmaniasis. Indian J Dermatol Venereol Leprol 74(1):23–27CrossRefPubMed
13.
go back to reference Yehia L, Adib-Houreih M, Raslan WF, Kibbi AG, Loya A, Firooz A, Satti M, El-Sabban M, Khalifeh I (2012) Molecular diagnosis of cutaneous leishmaniasis and species identification: analysis of 122 biopsies with varied parasite index. J Cutan Pathol 39(3):347–355. doi:10.1111/j.1600-0560.2011.01861.x CrossRefPubMed Yehia L, Adib-Houreih M, Raslan WF, Kibbi AG, Loya A, Firooz A, Satti M, El-Sabban M, Khalifeh I (2012) Molecular diagnosis of cutaneous leishmaniasis and species identification: analysis of 122 biopsies with varied parasite index. J Cutan Pathol 39(3):347–355. doi:10.​1111/​j.​1600-0560.​2011.​01861.​x CrossRefPubMed
15.
go back to reference Negera E, Gadisa E, Hussein J, Engers H, Kuru T, Gedamu L, Aseffa A (2012) Treatment response of cutaneous leishmaniasis due to Leishmania aethiopica to cryotherapy and generic sodium stibogluconate from patients in Silti, Ethiopia. Trans R Soc Trop Med Hyg 106(8):496–503. doi:10.1016/j.trstmh.2012.02.006 CrossRefPubMed Negera E, Gadisa E, Hussein J, Engers H, Kuru T, Gedamu L, Aseffa A (2012) Treatment response of cutaneous leishmaniasis due to Leishmania aethiopica to cryotherapy and generic sodium stibogluconate from patients in Silti, Ethiopia. Trans R Soc Trop Med Hyg 106(8):496–503. doi:10.​1016/​j.​trstmh.​2012.​02.​006 CrossRefPubMed
16.
go back to reference al-Zahrani MA, Peters W, Evans DA, Smith V, Ching Chin I (1989) Leishmania infecting man and wild animals in Saudi Arabia. 6. Cutaneous leishmaniasis of man in the south-west. Transactions of the Royal Society of Tropical Medicine and Hygiene 83(5):621–628 al-Zahrani MA, Peters W, Evans DA, Smith V, Ching Chin I (1989) Leishmania infecting man and wild animals in Saudi Arabia. 6. Cutaneous leishmaniasis of man in the south-west. Transactions of the Royal Society of Tropical Medicine and Hygiene 83(5):621–628
17.
go back to reference Sitheeque MA, Qazi AA, Ahmed GA (1990) A study of cutaneous leishmaniasis involvement of the lips and perioral tissues. Br J Oral Maxill Surg 28(1):43–46CrossRef Sitheeque MA, Qazi AA, Ahmed GA (1990) A study of cutaneous leishmaniasis involvement of the lips and perioral tissues. Br J Oral Maxill Surg 28(1):43–46CrossRef
18.
go back to reference Al-Tawfiq JA, AbuKhamsin A (2004) Cutaneous leishmaniasis: a 46-year study of the epidemiology and clinical features in Saudi Arabia (1956–2002). Int J Infect Dis IJID Off Publ Int Soc Infect Dis 8(4):244–250. doi:10.1016/j.ijid.2003.10.006 Al-Tawfiq JA, AbuKhamsin A (2004) Cutaneous leishmaniasis: a 46-year study of the epidemiology and clinical features in Saudi Arabia (1956–2002). Int J Infect Dis IJID Off Publ Int Soc Infect Dis 8(4):244–250. doi:10.​1016/​j.​ijid.​2003.​10.​006
19.
go back to reference Khatri ML, Di Muccio T, Gramiccia M (2009) Cutaneous leishmaniasis in North-Western Yemen: a clinicoepidemiologic study and Leishmania species identification by polymerase chain reaction-restriction fragment length polymorphism analysis. J Am Acad Dermatol 61(4):e15–e21. doi:10.1016/j.jaad.2009.04.047 CrossRefPubMed Khatri ML, Di Muccio T, Gramiccia M (2009) Cutaneous leishmaniasis in North-Western Yemen: a clinicoepidemiologic study and Leishmania species identification by polymerase chain reaction-restriction fragment length polymorphism analysis. J Am Acad Dermatol 61(4):e15–e21. doi:10.​1016/​j.​jaad.​2009.​04.​047 CrossRefPubMed
20.
go back to reference Gurel MS, Ulukanligil M, Ozbilge H (2002) Cutaneous leishmaniasis in Sanliurfa: epidemiologic and clinical features of the last four years (1997–2000). Int J Dermatol 41(1):32–37CrossRefPubMed Gurel MS, Ulukanligil M, Ozbilge H (2002) Cutaneous leishmaniasis in Sanliurfa: epidemiologic and clinical features of the last four years (1997–2000). Int J Dermatol 41(1):32–37CrossRefPubMed
21.
go back to reference Turhanoglu M, Alp Erdal S, Bayindir Bilman F (2014) A nine-year evaluation of cutaneous leishmaniasis patients in Diyarbakir Training and Research Hospital, Turkey. Mikrobiyol Bul 48(2):335–340CrossRefPubMed Turhanoglu M, Alp Erdal S, Bayindir Bilman F (2014) A nine-year evaluation of cutaneous leishmaniasis patients in Diyarbakir Training and Research Hospital, Turkey. Mikrobiyol Bul 48(2):335–340CrossRefPubMed
22.
go back to reference Sharma NL, Mahajan VK, Kanga A, Sood A, Katoch VM, Mauricio I, Singh CD, Parwan UC, Sharma VK, Sharma RC (2005) Localized cutaneous leishmaniasis due to Leishmania donovani and Leishmania tropica: preliminary findings of the study of 161 new cases from a new endemic focus in Himachal Pradesh, India. Am J Trop Med Hyg 72(6):819–824PubMed Sharma NL, Mahajan VK, Kanga A, Sood A, Katoch VM, Mauricio I, Singh CD, Parwan UC, Sharma VK, Sharma RC (2005) Localized cutaneous leishmaniasis due to Leishmania donovani and Leishmania tropica: preliminary findings of the study of 161 new cases from a new endemic focus in Himachal Pradesh, India. Am J Trop Med Hyg 72(6):819–824PubMed
25.
go back to reference Kharfi M, Benmously R, El Fekih N, Daoud M, Fitouri Z, Mokhtar I, Ben Becher S, Kamoun MR (2004) Childhood leishmaniasis: report of 106 cases. Dermatol Online J 10(2):6PubMed Kharfi M, Benmously R, El Fekih N, Daoud M, Fitouri Z, Mokhtar I, Ben Becher S, Kamoun MR (2004) Childhood leishmaniasis: report of 106 cases. Dermatol Online J 10(2):6PubMed
28.
go back to reference Schonian G, Nasereddin A, Dinse N, Schweynoch C, Schallig HD, Presber W, Jaffe CL (2003) PCR diagnosis and characterization of Leishmania in local and imported clinical samples. Diagn Microbiol Infect Dis 47(1):349–358CrossRefPubMed Schonian G, Nasereddin A, Dinse N, Schweynoch C, Schallig HD, Presber W, Jaffe CL (2003) PCR diagnosis and characterization of Leishmania in local and imported clinical samples. Diagn Microbiol Infect Dis 47(1):349–358CrossRefPubMed
30.
go back to reference Safaei A, Motazedian MH, Vasei M (2002) Polymerase chain reaction for diagnosis of cutaneous leishmaniasis in histologically positive, suspicious and negative skin biopsies. Dermatology 205(1):18–24CrossRefPubMed Safaei A, Motazedian MH, Vasei M (2002) Polymerase chain reaction for diagnosis of cutaneous leishmaniasis in histologically positive, suspicious and negative skin biopsies. Dermatology 205(1):18–24CrossRefPubMed
33.
go back to reference Organization WH (2014) Manual for case management of cutaneous leishmaniasis. 35:20 Organization WH (2014) Manual for case management of cutaneous leishmaniasis. 35:20
Metadata
Title
Head and neck cutaneous leishmania: clinical characteristics, microscopic features and molecular analysis in a cohort of 168 cases
Authors
Gabriel Dunya
Robert Habib
Roger V. Moukarbel
Ibrahim Khalifeh
Publication date
01-11-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 11/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-3978-5

Other articles of this Issue 11/2016

European Archives of Oto-Rhino-Laryngology 11/2016 Go to the issue