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Supportive Care in Cancer

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01-01-2019 | Original Article

Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study

Authors: T. Veni, S. Boyas, B. Beaune, H. Bourgeois, A. Rahmani, S. Landry, A. Bochereau, S. Durand, B. Morel

Published in: Supportive Care in Cancer | Issue 1/2019

Abstract

Purpose

As a subjective symptom, cancer-related fatigue is assessed via patient-reported outcomes. Due to the inherent bias of such evaluation, screening and treatment for cancer-related fatigue remains suboptimal. The purpose is to evaluate whether objective cancer patients’ hand muscle mechanical parameters (maximal force, critical force, force variability) extracted from a fatiguing handgrip exercise may be correlated to the different dimensions (physical, emotional, and cognitive) of cancer-related fatigue.

Methods

Fourteen women with advanced breast cancer, still under or having previously received chemotherapy within the preceding 3 months, and 11 healthy women participated to the present study. Cancer-related fatigue was first assessed through the EORTC QLQ-30 and its fatigue module. Fatigability was then measured during 60 maximal repeated handgrip contractions. The maximum force, critical force (asymptote of the force-time evolution), and force variability (root mean square of the successive differences) were extracted. Multiple regression models were performed to investigate the influence of the force parameters on cancer-related fatigue’s dimensions.

Results

The multiple linear regression analysis evidenced that physical fatigue was best explained by maximum force and critical force (r = 0.81; p = 0.029). The emotional fatigue was best explained by maximum force, critical force, and force variability (r = 0.83; p = 0.008). The cognitive fatigue was best explained by critical force and force variability (r = 0.62; p = 0.035).

Conclusion

The handgrip maximal force, critical force, and force variability may offer objective measures of the different dimensions of cancer-related fatigue and could provide a complementary approach to the patient reported outcomes.

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Title: Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study
Authors: T. Veni
S. Boyas
B. Beaune
H. Bourgeois
A. Rahmani
S. Landry
A. Bochereau
S. Durand
B. Morel
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 1/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4320-0

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