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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-04-2020 | Hamartoma | Oncology

Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex

Authors: Chenxi Zhang, Kaifeng Xu, Qin Long, Zhikun Yang, Rongping Dai, Hong Du, Donghui Li, Zhiqiao Zhang

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2020

Abstract

Purpose

To investigate the clinical features and spectral-domain optical coherence tomography (SD-OCT) findings of retinal astrocytic hamartoma (RAH) in Chinese patients with tuberous sclerosis complex (TSC).

Methods

The medical records of 91 consecutive patients with established TSC diagnosis were retrospectively reviewed. Fundus findings regarding RAH documented by fundus photography and SD-OCT at presentation were collected and analyzed.

Results

RAHs were seen in 69 of the 91 patients (75.8%); 50.7% of these patients showed bilateral retinal involvement. Type 1 RAH was found the most common type with a prevalence of 94.2%, while type 2 and type 3 RAH with 7.2% and 18.8% respectively. A significant correlation between age and RAH types was shown by Fisher’s exact test (p < 0.001). By SD-OCT, non-calcified RAHs featured in hyperreflective thickening of the retinal nerve fiber layer with some degree of retinal disorganization, while multinodular calcified RAHs characterized with moth-eaten appearances representing intraretinal calcification with posterior dense optical shadowing.

Conclusion

A higher prevalence of TSC-associated RAH but an unexpected lower prevalence of calcified RAHs was shown in Chinese compared with that of Caucasians. SD-OCT can be used to facilitate the detection and follow-up of RAHs.

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Title: Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex
Authors: Chenxi Zhang
Kaifeng Xu
Qin Long
Zhikun Yang
Rongping Dai
Hong Du
Donghui Li
Zhiqiao Zhang
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Hamartoma
Tuberous Sclerosis
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04476-y

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Springer Medicine

Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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