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Open Access 01-12-2018 | Review

Gut–kidney crosstalk in septic acute kidney injury

Authors: Jingxiao Zhang, Ghada Ankawi, Jian Sun, Kumar Digvijay, Yongjie Yin, Mitchell H. Rosner, Claudio Ronco

Published in: Critical Care | Issue 1/2018

Abstract

Sepsis is the leading cause of acute kidney injury (AKI) in the intensive care unit (ICU). Septic AKI is a complex and multifactorial process that is incompletely understood. During sepsis, the disruption of the mucus membrane barrier, a shift in intestinal microbial flora, and microbial translocation may lead to systemic inflammation, which further alters host immune and metabolic homeostasis. This altered homeostasis may promote and potentiate the development of AKI. As part of this vicious cycle, when AKI develops, the clearance of inflammatory mediators and metabolic products is decreased. This will lead to further gut injury and breakdown in mucous membrane barriers. Thus, changes in the gut during sepsis can initiate and propagate septic AKI. This deleterious gut–kidney crosstalk may be a potential target for therapeutic maneuvers. This review analyses the underlying mechanisms in gut–kidney crosstalk in septic AKI.

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Title: Gut–kidney crosstalk in septic acute kidney injury
Authors: Jingxiao Zhang
Ghada Ankawi
Jian Sun
Kumar Digvijay
Yongjie Yin
Mitchell H. Rosner
Claudio Ronco
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-018-2040-y

At a glance: The STEP trials

Springer Medicine

Gut–kidney crosstalk in septic acute kidney injury

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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