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01-03-2010 | Letter to the editors

Guillain–Barré syndrome after rituximab in a patient with idiopathic thombocytopenic purpura: a causal association?

Authors: Raquel Jaso, María Sierra, Jesús Calleja, Carmen Valero, Julio Pascual

Published in: Journal of Neurology | Issue 3/2010

Excerpt

Guillain–Barré syndrome (GBS) is an acute demyelinating inflammatory polyradiculoneuropathy characterised by rapidly progressing predominantly motor impairment and areflexia. Studies in patients and animals have provided convincing evidence that GBS is caused by an aberrant autoimmune response that damages peripheral nerves [1]. GBS rarely develops in patients who suffer from other autoimmune conditions, such as idiopathic thrombocytopenic purpura (ITP), which suggests a shared immune response [2‐11]. Rituximab is a monoclonal antibody particularly efficacious in the treatment of several haematological cancers, which has also been used for the treatment of some autoimmune conditions [12]. Here we report on a patient with ITP who developed a typical GBS after treatment with rituximab. …

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Title: Guillain–Barré syndrome after rituximab in a patient with idiopathic thombocytopenic purpura: a causal association?
Authors: Raquel Jaso
María Sierra
Jesús Calleja
Carmen Valero
Julio Pascual
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 3/2010
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-009-5400-3

At a glance: The STEP trials

Springer Medicine

Guillain–Barré syndrome after rituximab in a patient with idiopathic thombocytopenic purpura: a causal association?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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