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Tumor Biology
Published in: Tumor Biology 7/2014

01-07-2014 | Research Article

GSTM1 null polymorphisms is associated with laryngeal cancer risk: a meta-analysis

Authors: Yong Zhang, Wei Chen, Jun-feng Ji, Zhi-yi Wang, Ming-hai Wu, Kai Zhang, Qiu-ping Wang

Published in: Tumor Biology | Issue 7/2014

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Abstract

Many studies have examined the association between the GSTM1 (null or non-null genotype) polymorphism and laryngeal cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. PubMed was searched for case-control studies published up to December 2013. Data were extracted and pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated. Ultimately, 23 studies, comprising 2,562 laryngeal cancer cases and 4,091 controls, were included. Overall, for null versus present, the pooled OR was 1.22 (95 % CI = 1.10–1.36), and the heterogeneity was found in all studies. In the stratified analysis by ethnicity, significant risks were found among Asians (OR = 1.71; 95 % CI = 1.34–2.19; P = 0.011 for heterogeneity) and in Caucasians (OR = 1.13, 95 % CI = 1.00–1.27; P = 0.036 for heterogeneity). In conclusion, this meta-analysis demonstrates that the GSTM1 null gene polymorphism is an increased risk of laryngeal cancer in Asians and Caucasians.
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Metadata
Title
GSTM1 null polymorphisms is associated with laryngeal cancer risk: a meta-analysis
Authors
Yong Zhang
Wei Chen
Jun-feng Ji
Zhi-yi Wang
Ming-hai Wu
Kai Zhang
Qiu-ping Wang
Publication date
01-07-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 7/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1828-x

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