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Open Access 01-12-2013 | Study protocol

Growth and metabolic outcome in adolescents born preterm (GROWMORE): follow-up protocol for the Newcastle preterm birth growth study (PTBGS)

Authors: Claire L Wood, Robert J Tinnion, S Murthy Korada, Timothy D Cheetham, Caroline L Relton, Richard J Cooke, Mark S Pearce, Kieren G Hollingsworth, Michael I Trenell, Nicholas D Embleton

Published in: BMC Pediatrics | Issue 1/2013

Abstract

Background

Preterm infants represent up to 10% of births worldwide and have an increased risk of adverse metabolic outcomes in later life. Early life exposures are key factors in determining later health but current lifestyle factors such as diet and physical activity are also extremely important and provide an opportunity for targeted intervention.

Methods/Design

This current study, GROWMORE, is the fourth phase of the Newcastle Preterm Birth Growth Study (PTBGS), which was formed from two randomised controlled trials of nutrition in early life in preterm (24–34 weeks gestation) and low birthweight infants. 247 infants were recruited prior to hospital discharge. Infant follow-up included detailed measures of growth, nutritional intake, morbidities and body composition (Dual X Ray Absorptiometry, DXA) along with demographic data until 2 years corrected age. Developmental assessment was performed at 18 months corrected age, and cognitive assessment at 9–10 years of age. Growth, body composition (DXA), blood pressure and metabolic function (insulin resistance and lipid profile) were assessed at 9–13 years of age, and samples obtained for epigenetic analysis. In GROWMORE, we will follow up a representative cohort using established techniques and novel metabolic biomarkers and correlate these with current lifestyle factors including physical activity and dietary intake. We will assess auxology, body composition (BODPOD™), insulin resistance, daily activity levels using Actigraph™ software and use ³¹P and ¹H magnetic resonance spectroscopy to assess mitochondrial function and intra-hepatic lipid content.

Discussion

The Newcastle PTBGS is a unique cohort of children born preterm in the late 1990’s. The major strengths are the high level of detail of early nutritional and growth exposures, and the comprehensive assessment over time. This study aims to examine the associations between early life exposures in preterm infants and metabolic outcomes in adolescence, which represents an area of major translational importance.

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Gluckman PD, Hanson MA, Beedle AS: Early life events and their consequences for later disease: a life history and evolutionary perspective. Am J Hum Biol. 2007, 19: 1-19. 10.1002/ajhb.20590.CrossRefPubMed

Singhal A, Lucas A: Early origins of cardiovascular disease: is there a unifying hypothesis?. Lancet. 2004, 363: 1642-1645. 10.1016/S0140-6736(04)16210-7.CrossRefPubMed

March of Dimes, PMNCH, Save the Children, WHO: Born too soon. The Global Action Report on Preterm Birth. Edited by: Howson CP, Kinney MV, Lawn JE. 2012, Geneva: World Health Organization

Wood NS, Marlow N, Costeloe K, Gibson AT, Wilkinson AR: Neurologic and developmental disability after extremely preterm birth. EPICure Study Group.[see comment]. N Engl J Med. 2000, 343: 378-384. 10.1056/NEJM200008103430601.CrossRefPubMed

Embleton ND, Pang N, Cooke RJ: Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants?. Pediatrics. 2001, 107: 270-273. 10.1542/peds.107.2.270.CrossRefPubMed

Lucas A, Cole TJ: Breast milk and neonatal necrotising enterocolitis. [see comment]. Lancet. 1990, 336: 1519-1523. 10.1016/0140-6736(90)93304-8.CrossRefPubMed

Agostoni C, Buonocore G, Carnielli VP, De Curtis M, Darmaun D, Decsi T, Domellof M, Embleton ND, Fusch C, Genzel-Boroviczeny O, et al: Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010, 50: 85-91. 10.1097/MPG.0b013e3181adaee0.CrossRefPubMed

Stettler N: Nature and strength of epidemiological evidence for origins of childhood and adulthood obesity in the first year of life. Int J Obes (Lond). 2007, 31: 1035-1043. 10.1038/sj.ijo.0803659.CrossRef

Singhal A, Cole TJ, Lucas A: Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet. 2001, 357: 413-419. 10.1016/S0140-6736(00)04004-6.CrossRefPubMed

10.

Kajantie E, Osmond C, Barker DJP, Eriksson JG: Preterm birth - A risk factor for type 2 diabetes? The Helsinki Birth Cohort study. Diabetes Care. 2010, 33: 2623-2625. 10.2337/dc10-0912.CrossRefPubMedPubMedCentral

11.

Wehkalampi K, Hovi P, Dunkel L, Strang-Karlsson S, Jarvenpaa AL, Eriksson JG, Andersson S, Kajantie E: Advanced pubertal growth spurt in subjects born preterm: the Helsinki study of very low birth weight adults. J Clin Endocrinol Metab. 2011, 96: 525-533. 10.1210/jc.2010-1523.CrossRefPubMed

12.

Peralta-Carcelen M, Jackson DS, Goran MI, Royal SA, Mayo MS, Nelson KG: Growth of adolescents who were born at extremely low birth weight without major disability. J Pediatr. 2000, 136: 633-640. 10.1067/mpd.2000.104291.CrossRefPubMed

13.

Singhal A, Fewtrell M, Cole TJ, Lucas A: Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. [see comment]. Lancet. 2003, 361: 1089-1097. 10.1016/S0140-6736(03)12895-4.CrossRefPubMed

14.

Singhal A, Cole TJ, Fewtrell M, Deanfield J, Lucas A: Is slower early growth beneficial for long-term cardiovascular health?. Circulation. 2004, 109: 1108-1113. 10.1161/01.CIR.0000118500.23649.DF.CrossRefPubMed

15.

Fewtrell MS, Lucas A, Cole TJ, Wells JCK: Prematurity and reduced body fatness at 8–12 y of age. Am J Clin Nutr. 2004, 80: 436-440.PubMed

16.

Belfort MB, Martin CR, Smith VC, Gillman MW, McCormick MC: Infant weight gain and school-age blood pressure and cognition in former preterm infants. Pediatrics. 2010, 125: e1419-1426. 10.1542/peds.2009-2746.CrossRefPubMedPubMedCentral

17.

Isaacs EB, Morley R, Lucas A: Early diet and general cognitive outcome at adolescence in children born at or below 30 weeks gestation. J Pediatr. 2009, 155: 229-234. 10.1016/j.jpeds.2009.02.030.CrossRefPubMed

18.

Vasu V, Modi N: Assessing the impact of preterm nutrition. Early Hum Dev. 2007, 83: 813-818. 10.1016/j.earlhumdev.2007.09.008.CrossRefPubMed

19.

Oude Luttikhuis H, Baur L, Jansen H, Shrewsbury VA, O'Malley C, Stolk RP, Summerbell CD: Interventions for treating obesity in children. Cochrane Database Syst Rev. 2009, Issue 1. Art. No.: CD001872. DOI: 10.1002/14651858.CD001872.pub2

20.

Fewtrell MS, Kennedy K, Singhal A, Martin RM, Ness A, Hadders-Algra M, Koletzko B, Lucas A: How much loss to follow-up is acceptable in long-term randomised trials and prospective studies?. Arch Dis Child. 2008, 93: 458-461. 10.1136/adc.2007.127316.CrossRefPubMed

21.

Fraser A, Macdonald-Wallis C, Tilling K, Boyd A, Golding J, Davey Smith G, Henderson J, Macleod J, Molloy L, Ness A, et al: Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol. 2013, 42: 97-110. 10.1093/ije/dys066.CrossRefPubMed

22.

Parkinson KN, Pearce MS, Dale A, Reilly JJ, Drewett RF, Wright CM, Relton CL, McArdle P, Le Couteur AS, Adamson AJ: Cohort profile: the Gateshead Millennium Study. Int J Epidemiol. 2011, 40: 308-317. 10.1093/ije/dyq015.CrossRefPubMed

23.

Perala MM, Mannisto S, Kaartinen NE, Kajantie E, Osmond C, Barker DJ, Valsta LM, Eriksson JG: Body size at birth is associated with food and nutrient intake in adulthood. PLoS One. 2012, 7: e46139-10.1371/journal.pone.0046139.CrossRefPubMedPubMedCentral

24.

Syddall HE, Aihie Sayer A, Dennison EM, Martin HJ, Barker DJ, Cooper C: Cohort profile: the Hertfordshire cohort study. Int J Epidemiol. 2005, 34: 1234-1242. 10.1093/ije/dyi127.CrossRefPubMed

25.

Stanner SA, Bulmer K, Andres C, Lantseva OE, Borodina V, Poteen VV, Yudkin JS: Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ. 1997, 315: 1342-1348. 10.1136/bmj.315.7119.1342.CrossRefPubMedPubMedCentral

26.

Lumey LH, Stein AD, Kahn HS, van der Pal-de Bruin KM, Blauw GJ, Zybert PA, Susser ES: Cohort profile: the Dutch Hunger Winter families study. Int J Epidemiol. 2007, 36: 1196-1204. 10.1093/ije/dym126.CrossRefPubMed

27.

Singhal A, Wells J, Cole TJ, Fewtrell M, Lucas A: Programming of lean body mass: a link between birth weight, obesity, and cardiovascular disease?. Am J Clin Nutr. 2003, 77: 726-730.PubMed

28.

Sayer AA, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C, Barker DJ, Phillips DI: Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire cohort study. Am J Clin Nutr. 2004, 80: 199-203.PubMed

29.

Kuh D, Bassey J, Hardy R, Aihie Sayer A, Wadsworth M, Cooper C: Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol. 2002, 156: 627-633. 10.1093/aje/kwf099.CrossRefPubMed

30.

Cooke RJ, Embleton ND, Griffin IJ, Wells JC, McCormick KP: Feeding preterm infants after hospital discharge: Growth and development at 18 months of age. Pediatr Res. 2001, 49: 719-722. 10.1203/00006450-200105000-00018.CrossRefPubMed

31.

Embleton ND, Cooke RJ: Protein requirements in preterm infants: effect of different levels of protein intake on growth and body composition. Pediatr Res. 2005, 58: 855-860. 10.1203/01.PDR.0000182586.46532.7C.CrossRefPubMed

32.

Cooke RJ, McCormick K, Griffin IJ, Embleton ND, Faulkner K, Wells JC, Rawlings DC: Feeding preterm infants after hospital discharge: effect of diet on body composition. Pediatr Res. 1999, 46: 461-464. 10.1203/00006450-199910000-00017.CrossRefPubMed

33.

Tinnion RJ, Hollingsworth K, Basterfield L, Trenell M, Cheetham TD, Embleton ND: Markers of the metabolic syndrome and physical activity in teenage children born preterm. 2012, Istanbul, Turkey: European Academy of Pediatric Societies

34.

Sinha A, Hollingsworth KG, Ball S, Cheetham T: Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. J Clin Endocrinol Metab. 2013, 98: E509-513. 10.1210/jc.2012-3592.CrossRefPubMed

35.

Cole TJ: Growth monitoring with the British 1990 growth reference. Arch Dis Child. 1997, 76: 47-49. 10.1136/adc.76.1.47.CrossRefPubMedPubMedCentral

36.

Cole TJ, Freeman JV, Preece MA: British 1990 growth reference centiles for weight, height, body mass index and head circumference fitted by maximum penalized likelihood. Stat Med. 1998, 17: 407-429. 10.1002/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L.CrossRefPubMed

37.

Durnin JVGA, Rahaman MM: The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr. 1967, 21: 681-689. 10.1079/BJN19670070.CrossRefPubMed

38.

Durnin JVGA, Womersley J: Body Fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974, 32: 77-97. 10.1079/BJN19740060.CrossRefPubMed

39.

Fields DA, Goran MI, McCrory MA: Body-composition assessment via air-displacement plethysmography in adults and children: a review. Am J Clin Nutr. 2002, 75: 453-467.PubMed

40.

Ball SD: Interdevice variability in percent fat estimates using the BOD POD. Eur J Clin Nutr. 2005, 59: 996-1001. 10.1038/sj.ejcn.1602202.CrossRefPubMed

41.

Fields DA, Goran MI: Body composition techniques and the four-compartment model in children. J Appl Physiol. 2000, 89: 613-620.PubMed

42.

Colley CM, Larner JR: The use of Fortical in glucose tolerance tests. Ann Clin Biochem. 1990, 27 (Pt 5): 496-498.CrossRefPubMed

43.

Relton CL, Davey Smith G: Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS Med. 2010, 7: e1000356-10.1371/journal.pmed.1000356.CrossRefPubMedPubMedCentral

44.

Groom A, Elliott HR, Embleton ND, Relton CL: Epigenetics and child health: basic principles. Arch Dis Child. 2011, 96: 863-869. 10.1136/adc.2009.165712.CrossRefPubMed

45.

Human Tissue Act. http://www.legislation.gov.uk/ukpga/2004/30/contents,

46.

Groom A, Potter C, Swan DC, Fatemifar G, Evans DM, Ring SM, Turcot V, Pearce MS, Embleton ND, Smith GD, et al: Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass. Diabetes. 2012, 61: 391-400. 10.2337/db11-1039.CrossRefPubMedPubMedCentral

47.

Relton CL, Groom A, St Pourcain B, Sayers AE, Swan DC, Embleton ND, Pearce MS, Ring SM, Northstone K, Tobias JH, et al: DNA methylation patterns in cord blood DNA and body size in childhood. PLoS One. 2012, 7: e31821-10.1371/journal.pone.0031821.CrossRefPubMedPubMedCentral

48.

Turcot V, Groom A, McConnell JC, Pearce MS, Potter C, Embleton ND, Swan DC, Relton CL: Bioinformatic selection of putative epigenetically regulated loci associated with obesity using gene expression data. Gene. 2012, 499: 99-107. 10.1016/j.gene.2012.02.001.CrossRefPubMed

49.

Qayyum A: MR spectroscopy of the liver: principles and clinical applications. Radiographics. 2009, 29: 1653-1664. 10.1148/rg.296095520.CrossRefPubMed

50.

Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, de Beer R, Graveron-Demilly D: Java-based graphical user interface for the MRUI quantitation package. MAGMA. 2001, 12: 141-152.CrossRefPubMed

51.

Thomas EL, Hamilton G, Patel N, O'Dwyer R, Dore CJ, Goldin RD, Bell JD, Taylor-Robinson SD: Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut. 2005, 54: 122-127. 10.1136/gut.2003.036566.CrossRefPubMedPubMedCentral

52.

Gardner CJ, Irwin AJ, Daousi C, McFarlane IA, Joseph F, Bell JD, Thomas EL, Adams VL, Kemp GJ, Cuthbertson DJ: Hepatic steatosis, GH deficiency and the effects of GH replacement: a Liverpool magnetic resonance spectroscopy study. Eur J Endocrinol. 2012, 166: 993-1002. 10.1530/EJE-12-0002.CrossRefPubMed

53.

Jones DE, Hollingsworth KG, Taylor R, Blamire AM, Newton JL: Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome. J Intern Med. 2010, 267: 394-401. 10.1111/j.1365-2796.2009.02160.x.CrossRefPubMed

54.

Trenell MI, Hollingsworth KG, Lim EL, Taylor R: Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes. Diabetes Care. 2008, 31: 1644-1649. 10.2337/dc08-0303.CrossRefPubMedPubMedCentral

55.

Newcastle Magnetic Resonance Centre at Newcastle University: http://www.ncl.ac.uk/magres/assets/photos/liverpic1.jpg. Last accessed 05/12/2013

56.

Vanhamme L, van den Boogaart A, Van Huffel S: Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson. 1997, 129: 35-43. 10.1006/jmre.1997.1244.CrossRefPubMed

57.

Kemp GJ, Radda GK: Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review. Magn Reson Q. 1994, 10: 43-63.PubMed

58.

Basterfield L, Adamson AJ, Parkinson KN, Maute U, Li PX, Reilly JJ: Surveillance of physical activity in the UK is flawed: validation of the health survey for England physical activity questionnaire. Arch Dis Child. 2008, 93: 1054-1058. 10.1136/adc.2007.135905.CrossRefPubMed

59.

Metcalf BS, Voss LD, Wilkin TJ: Accelerometers identify inactive and potentially obese children (EarlyBird 3). Arch Dis Child. 2002, 87: 166-167. 10.1136/adc.87.2.166.CrossRefPubMedPubMedCentral

60.

Basterfield L, Pearce MS, Adamson AJ, Frary JK, Parkinson KN, Wright CM, Reilly JJ, Gateshead Millennium Study Core T: Physical activity, sedentary behavior, and adiposity in English children. Am J Prev Med. 2012, 42: 445-451. 10.1016/j.amepre.2012.01.007.CrossRefPubMed

61.

Foster E, Hawkins A, Delve J, Adamson AJ: Reducing the cost of dietary assessment: Self-Completed Recall and Analysis of Nutrition for use with children (SCRAN24). J Hum Nutr Diet. 2013, Epub ahead of print

62.

Cooke RJ, Griffin IJ, McCormick K: Adiposity is not altered in preterm infants fed with a nutrient-enriched formula after hospital discharge. Pediatr Res. 2010, 67: 660-664. 10.1203/PDR.0b013e3181da8d01.CrossRefPubMed

63.

Cooke RJ, Griffin IJ, McCormick K, Wells JC, Smith JS, Robinson SJ, Leighton M: Feeding preterm infants after hospital discharge: effect of dietary manipulation on nutrient intake and growth. Pediatr Res. 1998, 43: 355-360. 10.1203/00006450-199803000-00008.CrossRefPubMed

64.

Korada SM, Cheetham TD, Pearce MS, Tennant P, Embleton ND: Insulin sensitivity and body composition in 11 year old children born preterm. 2009, Baltimore, USA: Pediatric Academic Society, Society for Pediatric Research

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2431/13/213/prepub

Title: Growth and metabolic outcome in adolescents born preterm (GROWMORE): follow-up protocol for the Newcastle preterm birth growth study (PTBGS)
Authors: Claire L Wood
Robert J Tinnion
S Murthy Korada
Timothy D Cheetham
Caroline L Relton
Richard J Cooke
Mark S Pearce
Kieren G Hollingsworth
Michael I Trenell
Nicholas D Embleton
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Pediatrics / Issue 1/2013
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/1471-2431-13-213

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Growth and metabolic outcome in adolescents born preterm (GROWMORE): follow-up protocol for the Newcastle preterm birth growth study (PTBGS)

Abstract

Background

Methods/Design

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods/Design

Discussion

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