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01-03-2017 | Review Article

Growing Teratoma Syndrome

Authors: S. P. Kataria, Ankur Nandan Varshney, Mukesh Nagar, A. K. Mandal, Vidya Jha

Published in: Indian Journal of Surgical Oncology | Issue 1/2017

Abstract

Growing teratoma syndrome, a disease characterized by presence of benign metastasis increasing in size and number after chemotherapy, is infrequent occurrence. Being unfamiliar with the disease entity, many oncologists misinterpret it as disease progression. Though the exact etio-pathognesis of the disease is still unidentified, but clinical characteristics are well defined. Being a chemo and radio-resistant disease, surgery offers only cure. We present a case of ovarian immature teratoma, who after chemotherapy presented with increased tumor size. Resected specimen confirms the diagnosis of mature teratoma leading to recognition of GTS. Surgery resulted in cure.

Logothetis CJ, Logothetis CJ, Samuels ML, Trindade A, Johnson DE (1982) The growing teratoma syndrome. Cancer 50:1629–1635CrossRefPubMed

Smithers DW (1969) Maturation in human tumours. Lancet 2:949–952CrossRefPubMed

Willis GW, Hajdu SI (1973) Histologically benign teratoid metastasis of testicular embryonal carcinoma. Am J Clin Pathol 59:338–343CrossRefPubMed

Merrin C, Baumbgartner G, Wajsman Z (1975) Benign transformation of testicular carcinoma by chemotherapy. Lancet 1:43–44CrossRefPubMed

DiSaia PJ, Saltz A, Kagan AR, Morrow CP (1977) Chemotherapeutic retroconversion of immature teratoma of the ovary. Obstet Gynecol 49:346–350PubMed

Hong WK, Wittes RE, Hajdu ST, Cvitkovic E, Whitmore WF, Golbey RB (1977) The evolution of mature teratoma from malignant testicular tumors. Cancer 40:2987–2992CrossRefPubMed

Carr BI, Gilchrist KW, Carbone PP (1981) The variable transformation in metastases from testicular germ cell tumors: the need for selective biopsy. J Urol 126:52–54PubMed

Amsalem H, Nadjari M, Prus D, Hiller N, Benshushan A (2004) Growing teratoma syndrome vs. chemotherapeutic retroconversion: case report and review of literature. Gynecol Oncol 92:357–360CrossRefPubMed

Djordjevic B, Euscher ED, Malpica A (2007) Growing teratoma syndrome of the ovary: review of literature and first report of a carcinoid tumor arising in a growing teratoma of the ovary. Am J Surg Pathol 31:1913–1918CrossRefPubMed

10.

Gorbatiy V, Spiess PE, Pisters LL (2009) The growing teratoma syndrome: current review of the literature. Indian J Urol 25:186–189CrossRefPubMedPubMedCentral

11.

Andre F, Fizazi K, Culine S, Droz J, Taupin P, Lhomme C et al (2000) The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer 36:1389–1394CrossRefPubMed

12.

Zagame L, Pautier P, Duvillard P et al (2006) Growing teratoma syndrome after ovarian germ cell tumors. Obstet Gynecol 108:509–514CrossRefPubMed

13.

Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM (1991) The growing teratoma syndrome. Br J Urol 67:195–202CrossRefPubMed

14.

O’Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM (1997) The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland. Cancer 80:942–947CrossRefPubMed

15.

Dees JE (1973) Metastatic embryonal cell carcinoma of testis: an apparent 8-year cure. J Urol 110:90–92PubMed

16.

Maroto P, Tabernero JM, Villavicencio H, Mesla R, Marcuello E, Sole-Balcells FJ et al (1997) Growing teratoma syndrome: experience of a single institution. Eur Urol 32:305–309PubMed

17.

Bentivegna E, Gonthier C, Uzan C et al (2015) Gliomatosis peritonei: a particular entity with specific outcomes within the growing teratoma syndrome. Int J Gynaecol Cancer 25:244–249CrossRef

18.

Spiess PE, Tannir NM, Tu SM, Brown GA, Liu P, Kamat AM et al (2007) Viable germ cell tumor at postchemotherapy retroperitoneal lymph node dissection: can we predict patients at risk of disease progression? Cancer 110:2700–2708CrossRefPubMed

19.

Pendlebury A, Rischin D, Jenkin KI, Toner GC, Grant P (2015) Ovarian growing teratoma syndrome with spuriously elevated alpha-fetoprotein. J Clin Onco 33(24):e-99–e100CrossRef

20.

Nimkin K, Gupta P, McCauley R, Gilchrist BF, Lessin MS (2004) The growing teratoma syndrome. Pediatr Radiol 34:259–262CrossRefPubMed

21.

Spiess PE, Kassouf W, Brown GA, Kamat AM, Liu P, Gomez JA et al (2007) Surgical management of growing teratoma syndrome: the M. D. Anderson cancer center experience. J Urol 177:1330–1334CrossRefPubMed

22.

Aide N, Comoz F, Savin E (2007) Enlarging residual mass after treatment of a nonseminomatous germ cell tumor: growing teratoma syndrome or cancer recurrence? J Clin Oncol 25:4494–4496CrossRefPubMed

23.

Hariprasad R, Kumar L, Janga D et al (2008) Growing teratoma syndrome of ovary. Int J Clin Oncol 13:83–87CrossRefPubMed

24.

Sengar AR, Kulkarni JN (2010) Growing teratoma syndrome in a post laparoscopic excision of ovarian immature teratoma. J Gynaecol Oncol 21:129–131CrossRef

25.

Tangjitgamol S, Manusirivithaya S, Leelahakorn S, Thawaramara T, Suekwatana P, Sheanakul C (2006) The growing teratoma syndrome: a case report and a review of literature. Int J Gynecol Cancer 16:384–390CrossRefPubMed

26.

Kattan J, Droz JP, Culine S, Duvillard P, Theiellet A, Peillon C (1993) The growing teratoma syndrome: a woman with nonseminomatous germ cell tumor of the ovary. Gynecol Oncol 49:395–399CrossRefPubMed

27.

Rustin GJS, Kaye SB, Williams CJ, Newlands ES, Bagshawe KD, Toy JL (1982) Response of differentiated but not anaplastic teratoma to interferon. Br J Cancer 50:611–616CrossRef

28.

Mego M, Reckova M, Sycova-Mila Z, Obertova J, Brozmanova K, Salek T, Mardiak J (2007) Bevacizumab in a growing teratoma syndrome. Case report Ann Oncol 18:962–963PubMed

29.

Vaughn DJ, Flaherty K, Lal P et al (2009) Treatment of growing teratoma syndrome. N Engl J Med 360(4):423–424CrossRefPubMed

Title: Growing Teratoma Syndrome
Authors: S. P. Kataria
Ankur Nandan Varshney
Mukesh Nagar
A. K. Mandal
Vidya Jha
Publication date: 01-03-2017
Publisher: Springer India
Published in: Indian Journal of Surgical Oncology / Issue 1/2017
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-016-0568-3

At a glance: The STEP trials

Springer Medicine

Growing Teratoma Syndrome

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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