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BioPsychoSocial Medicine
Published in: BioPsychoSocial Medicine 1/2008

Open Access 01-12-2008 | Research

Green odor attenuates a cold pressor test-induced cardiovascular response in healthy adults

Authors: Takakazu Oka, Sota Hayashida, Yuko Kaneda, Masaki Takenaga, Yoko Tamagawa, Sadatoshi Tsuji, Akikazu Hatanaka

Published in: BioPsychoSocial Medicine | Issue 1/2008

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Abstract

Background

Green odor, a mixture of equal amounts of 2E-hexenal (leaf aldehyde) and 3Z-hexenol (leaf alcohol) has been demonstrated to have an anti-stress effect in rats. This study investigated whether or not green odor also has an anti-stress effect in humans.

Methods

Changes in blood pressure, heart rate, and the skin temperature of a fingertip were observed after presenting green odor at a concentration of 0.03% or vehicle via inhalation through the nose for 10 min to eight healthy normotensive adults. We also assessed the pleasantness of green odor and its effect on mood states via assessment with the Profile of Mood States (POMS) questionnaire. Cardiovascular response to green odor and the vehicle were compared among 11 additional healthy adults by use of the cold pressor test.

Results

Of 19 subjects, 15 (79%) reported that the green odor was pleasant. Green odor had no effect on blood pressure, heart rate, skin temperature, or POMS score under non-stressful conditions. In the second experiment, green odor attenuated cold pressor test-induced increases in systolic and diastolic blood pressure and facilitated the recovery of skin temperature.

Conclusion

These findings suggest that green odor has an anti-stress effect in healthy humans.
Appendix
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Literature
1.
Hatanaka A: The fresh green odor emitted by plants. Food Rev Int. 1996, 12: 303-50.CrossRef
2.
Nakamura S, Hatanaka A: Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria. J Agric Food Chem. 2002, 50: 7639-44. 10.1021/jf025808c.CrossRefPubMed
3.
Hatanaka A: So-called "green odor" as plant origin – chemistry and biochemistry. Seikagaku. 2003, 75: 1414-28.PubMed
4.
Aou S, Mizuno M, Matsunaga Y, Kubo K, Li XL, Hatanaka A: Green odor reduces pain sensation and fatigue-like responses without affecting sensorimotor function. Chem Senses. 2005, 30 (Suppl 1): i262-3. 10.1093/chemse/bjh215.CrossRefPubMed
5.
Watanabe Y, Sasabe T, Yamaguti K, Kobayashi M, Yamamoto S, Kuratsune H, Sano K, Hatanaka A, Tsukada H, Onoe H: Prevention and/or recovery effects by green odor(s) on fatigue and green-odor-responsible brain regions as revealed by PET. Chem Senses. 2005, 30 (Suppl 1): i268-9. 10.1093/chemse/bjh218.CrossRefPubMed
6.
Tokumo K, Tamura N, Hirai T, Nishio H: Effects of (Z)-3-hexenol, a major component of green odor, on anxiety-related behavior of the mouse in an elevated plus-maze test and biogenic amines and their metabolites in the brain. Behav Brain Res. 2006, 166: 247-52. 10.1016/j.bbr.2005.08.008.CrossRefPubMed
7.
Sano K, Tsuda Y, Sugano H, Aou S, Hatanaka A: Concentration effects of green odor on event-related potential (P300) and pleasantness. Chem Senses. 2002, 27: 225-30. 10.1093/chemse/27.3.225.CrossRefPubMed
8.
Nakashima T, Akamatsu M, Hatanaka A, Kiyohara T: Attenuation of stress-induced elevations in plasma ACTH level and body temperature in rats by green odor. Physiol Behav. 2004, 80: 481-8. 10.1016/j.physbeh.2003.10.008.CrossRefPubMed
9.
Akutsu H, Kikusui T, Takeuchi Y, Sano K, Hatanaka A, Mori Y: Alleviating effects of plant-derived fragrances on stress-induced hyperthermia in rats. Physiol Behav. 2002, 75: 355-60. 10.1016/S0031-9384(01)00670-9.CrossRefPubMed
10.
McNair D, Lorr M, Droppleman L: Mannual for the Profile of Mood States (POMS). 1971, San Diego, CA: Educational and Industrial Testing Service
11.
Oka T, Oka K, Hori T: Mechanisms and mediators of psychological stress-induced rise in core temperature. Psychosom Med. 2001, 63: 476-86.CrossRefPubMed
12.
Oka T, Oka K, Kobayashi T, Sugimoto Y, Ichikawa A, Ushikubi F, Narumiya S, Saper CB: Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors. J Physiol. 2003, 551: 945-54. 10.1113/jphysiol.2003.048140.CrossRefPubMedPubMedCentral
13.
Oka T, Oka K: Age and gender differences of psychogenic fever: a review of the Japanese literature. Biopsychosoc Med. 2007, 1: 11-10.1186/1751-0759-1-11.CrossRefPubMedPubMedCentral
14.
Hayashida S, Oka T, Tsuji S: Cilnidipine lowered psychological stress-induced increase in blood pressure in a hypertensive man: A case report. Biopsychosoc Med. 2007, 1: 16-10.1186/1751-0759-1-16.CrossRefPubMedPubMedCentral
15.
Kim J, Ishibashi M, Nakajima K, Aou S, Hatanaka A, Oomura Y, Sasaki K: Effects of green odor on expression of Fos-immunoreactivity in the paraventricular nucleus of the thalamus in forced swimming rats. Chem Senses. 2005, 30 (Suppl 1): i266-7. 10.1093/chemse/bjh217.CrossRefPubMed
16.
Otake K, Kin K, Nakamura Y: Fos expression in afferents to the rat midline thalamus following immobilization stress. Neurosci Res. 2002, 43: 269-82. 10.1016/S0168-0102(02)00042-1.CrossRefPubMed
17.
Spencer SJ, Fox JC, Day TA: Thalamic paraventricular nucleus lesions facilitate amygdale neuronal response to acute psychological stress. Brain Res. 2004, 997: 234-7. 10.1016/j.brainres.2003.10.054.CrossRefPubMed
18.
Sasabe T, Kobayashi M, Kondo Y, Onoe H, Matsubara S, Yamamoto S, Tsukada H, Onoe K, Watabe H, Iida H, Kogo M, Sano K, Hatanaka A, Sawada T, Watanabe Y: Activation of the anterior cingulate gyrus by 'Green Odor': a positron emission tomography study in the monkey. Chem Senses. 2003, 28: 565-72. 10.1093/chemse/bjg048.CrossRefPubMed
19.
Bush G, Luu P, Posner MI: Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci. 2000, 4: 215-22. 10.1016/S1364-6613(00)01483-2.CrossRefPubMed
Metadata
Title
Green odor attenuates a cold pressor test-induced cardiovascular response in healthy adults
Authors
Takakazu Oka
Sota Hayashida
Yuko Kaneda
Masaki Takenaga
Yoko Tamagawa
Sadatoshi Tsuji
Akikazu Hatanaka
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BioPsychoSocial Medicine / Issue 1/2008
Electronic ISSN: 1751-0759
DOI
https://doi.org/10.1186/1751-0759-2-2

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