Skip to main content
Top
Published in: Virchows Archiv 3/2005

01-09-2005 | Case Report

Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation

Authors: Paulo R. Benites Filho, Daniele Sakamoto, Tiago Noguchi Machuca, Maria José Serapião, Leo Ditzel, Luiz F. Bleggi Torres

Published in: Virchows Archiv | Issue 3/2005

Login to get access

Abstract

Granular cell tumor (GCT) usually occurs as a solitary, small, nodular tumor and rarely grows to a sufficient size to present symptoms. The tumor is more prevalent in female adults. The authors report a case of an 8-year-old boy with GCT of the neurohypophysis presenting with central precocious puberty. Few cases of symptomatic GCT have been reported in the literature, none of them in a patient in the first decade of life. Clinical picture, histopathological features, and histogenesis of GCT of neurohypophysis are discussed.
Literature
1.
go back to reference Asa LS (1998) Tumors of the pituitary gland. In: Atlas of tumor pathology, fasc 22, 3rd edn. Armed Forces Institute of Pathology, Washington, D.C., pp 159–160 Asa LS (1998) Tumors of the pituitary gland. In: Atlas of tumor pathology, fasc 22, 3rd edn. Armed Forces Institute of Pathology, Washington, D.C., pp 159–160
2.
go back to reference Barrande G, Kujas M, Gancel A, Turpin G, Bruckert E, Kuhn JM, Luton JP (1995) Granular cell tumors. Rare tumors of the neurohypophysis. Presse Med 24(30):1376–1380PubMed Barrande G, Kujas M, Gancel A, Turpin G, Bruckert E, Kuhn JM, Luton JP (1995) Granular cell tumors. Rare tumors of the neurohypophysis. Presse Med 24(30):1376–1380PubMed
3.
go back to reference Becker DH, Wilson CB (1981) Symptomatic parasellar granular cell tumors. Neurosurgery 8:173–180PubMed Becker DH, Wilson CB (1981) Symptomatic parasellar granular cell tumors. Neurosurgery 8:173–180PubMed
4.
go back to reference Buley ID, Gatter KC, Kelly PMA (1988) Granular cell tumors revisited. An immunohistological and ultrastructural study. Histopathology 12:263–274PubMed Buley ID, Gatter KC, Kelly PMA (1988) Granular cell tumors revisited. An immunohistological and ultrastructural study. Histopathology 12:263–274PubMed
5.
go back to reference Chermaitilly W, Trivin C, Adan L, Gail V, Sainte-Rose C, Brauner R (2001) Central precocious puberty: clinical and laboratory features. Clin Endocrin (Oxf) 54:289–294CrossRef Chermaitilly W, Trivin C, Adan L, Gail V, Sainte-Rose C, Brauner R (2001) Central precocious puberty: clinical and laboratory features. Clin Endocrin (Oxf) 54:289–294CrossRef
6.
go back to reference Cusick JF, Ho K, Hagern TC, Kun L (1982) Granular cell pituicytoma associated with multiple endocrine neoplasia type 2. J Neurosurg 56:594–596PubMed Cusick JF, Ho K, Hagern TC, Kun L (1982) Granular cell pituicytoma associated with multiple endocrine neoplasia type 2. J Neurosurg 56:594–596PubMed
7.
go back to reference Kasashima S, Oda Y, Nozaki J, Shirasaki M, Nakanishi I (2000) A case of atypical granular cell tumor of the neurohypophysis. Pathol Int 50:568–573CrossRefPubMed Kasashima S, Oda Y, Nozaki J, Shirasaki M, Nakanishi I (2000) A case of atypical granular cell tumor of the neurohypophysis. Pathol Int 50:568–573CrossRefPubMed
8.
go back to reference Lafitte C, Aesch B, Henry-Lebras F, Fetissof F, Jan M (1994) Granular cell tumor of the pituitary stalk. J Neurosurg 80:1103–1107PubMed Lafitte C, Aesch B, Henry-Lebras F, Fetissof F, Jan M (1994) Granular cell tumor of the pituitary stalk. J Neurosurg 80:1103–1107PubMed
9.
go back to reference Liwnicz BH, Liwnicz RG, Huff JS, McBride BH, Tew JM (1984) Giant granular cell tumor of the suprasellar area: immunocytochemical and electron microscopy studies. Neurosurgery 15:246–251PubMed Liwnicz BH, Liwnicz RG, Huff JS, McBride BH, Tew JM (1984) Giant granular cell tumor of the suprasellar area: immunocytochemical and electron microscopy studies. Neurosurgery 15:246–251PubMed
10.
go back to reference Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M (2000) Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. J Neurosurg 93:121–126PubMed Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M (2000) Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. J Neurosurg 93:121–126PubMed
11.
go back to reference Lüthy F, Klinger J (1951) Der Tumoretten-Tumor des Hypophysenhinterlappens. Schweiz Z Allg Pathol Bakteriol 14:721–729 Lüthy F, Klinger J (1951) Der Tumoretten-Tumor des Hypophysenhinterlappens. Schweiz Z Allg Pathol Bakteriol 14:721–729
12.
go back to reference Markesberry WR, Duffy PE, Cowen D (1973) Granular cell tumors of the central nervous system. J Neuropathol Exp Neurol 32:92–109 Markesberry WR, Duffy PE, Cowen D (1973) Granular cell tumors of the central nervous system. J Neuropathol Exp Neurol 32:92–109
13.
14.
go back to reference Miettinen M, Lehtonen E, Lehtola H, Ekblorm P, Lehto VP, Virtanen I (1984) Histogenesis of granular cell tumor—an immunohistochemical and ultrastructural study. J Pathol 142:221–229CrossRefPubMed Miettinen M, Lehtonen E, Lehtola H, Ekblorm P, Lehto VP, Virtanen I (1984) Histogenesis of granular cell tumor—an immunohistochemical and ultrastructural study. J Pathol 142:221–229CrossRefPubMed
15.
go back to reference Nathrath WBJ, Remberger K (1986) Immunohistochemical study of the granular cell tumors. Virchows Arch B 53:52–57 Nathrath WBJ, Remberger K (1986) Immunohistochemical study of the granular cell tumors. Virchows Arch B 53:52–57
16.
go back to reference Nishio S, Takeshita I, Yoshimoto K, Yamaguchi T (1998) Granular cell tumor of the pituitary stalk. Clin Neurol Neurosurg 100:144–147CrossRefPubMed Nishio S, Takeshita I, Yoshimoto K, Yamaguchi T (1998) Granular cell tumor of the pituitary stalk. Clin Neurol Neurosurg 100:144–147CrossRefPubMed
17.
go back to reference Nishioka H, Kunio L, Llena JF, Hirano A (1991) Immunohistochemical study of granular cell tumors of the neurohypophysis. Virchows Arch B 60:413–417PubMed Nishioka H, Kunio L, Llena JF, Hirano A (1991) Immunohistochemical study of granular cell tumors of the neurohypophysis. Virchows Arch B 60:413–417PubMed
18.
go back to reference Rhee JS, Wackym PA, Hague K, King WA, Wolfe D (2002) Granular cell tumor of the pituitary fossa. Ann Otol Rhinol Laryngol 111:754–758PubMed Rhee JS, Wackym PA, Hague K, King WA, Wolfe D (2002) Granular cell tumor of the pituitary fossa. Ann Otol Rhinol Laryngol 111:754–758PubMed
19.
go back to reference Sarah A, Kernohan JW (1955) Granular cell tumors of the stalk and posterior lobe of the pituitary gland. Cancer 8(3):616–622PubMed Sarah A, Kernohan JW (1955) Granular cell tumors of the stalk and posterior lobe of the pituitary gland. Cancer 8(3):616–622PubMed
20.
go back to reference Satyamurti S, Huntington HW (1972) Granular cell myoblastoma of the pituitary. J Neurosurg 37:483–486PubMed Satyamurti S, Huntington HW (1972) Granular cell myoblastoma of the pituitary. J Neurosurg 37:483–486PubMed
21.
go back to reference Schaller B, Kirsch E, Tolnay M, Mindermann T (1998) Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–171CrossRefPubMed Schaller B, Kirsch E, Tolnay M, Mindermann T (1998) Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–171CrossRefPubMed
22.
go back to reference Symon L, Ganz JC, Burston J (1971) Granular cell myoblastoma of the neurohypophysis. J Neurosurg 35:82–89PubMed Symon L, Ganz JC, Burston J (1971) Granular cell myoblastoma of the neurohypophysis. J Neurosurg 35:82–89PubMed
23.
go back to reference Stanhope R (2001) Central precocious puberty and occult intracranial tumors. Clin Endocrin (Oxf) 54:287–288CrossRef Stanhope R (2001) Central precocious puberty and occult intracranial tumors. Clin Endocrin (Oxf) 54:287–288CrossRef
24.
go back to reference Sterberg C (1921) Ein Choristoma der Neruohypophyse bei ausgebreiteten Oedemen. Zentralbl Pathol Anat 31:585–591 Sterberg C (1921) Ein Choristoma der Neruohypophyse bei ausgebreiteten Oedemen. Zentralbl Pathol Anat 31:585–591
25.
go back to reference Tomita T, Gates E (1999) Pituitary adenomas and granular cell tumors. Incidence, cell type, and location of tumors in 100 pituitary glands at autopsy. Am J Clin Pathol 111:817–825PubMed Tomita T, Gates E (1999) Pituitary adenomas and granular cell tumors. Incidence, cell type, and location of tumors in 100 pituitary glands at autopsy. Am J Clin Pathol 111:817–825PubMed
26.
go back to reference Ulrich J, Heitz PU, Fischer T, Obrist E, Gullotta F (1987) Granular cell tumors—evidence for heterogeneous tumor cell differentiation. An immunohistochemical study. Virchows Arch B 53:52–57PubMed Ulrich J, Heitz PU, Fischer T, Obrist E, Gullotta F (1987) Granular cell tumors—evidence for heterogeneous tumor cell differentiation. An immunohistochemical study. Virchows Arch B 53:52–57PubMed
27.
go back to reference Vogelgesang S, Junge MH, Pahnke J, Gaab MR, Warzok W (2002) August 2001: Sellar/Suparasellar mass in a 59 year-old woman. Brain Pathol 12(1):135–136, 139PubMed Vogelgesang S, Junge MH, Pahnke J, Gaab MR, Warzok W (2002) August 2001: Sellar/Suparasellar mass in a 59 year-old woman. Brain Pathol 12(1):135–136, 139PubMed
Metadata
Title
Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation
Authors
Paulo R. Benites Filho
Daniele Sakamoto
Tiago Noguchi Machuca
Maria José Serapião
Leo Ditzel
Luiz F. Bleggi Torres
Publication date
01-09-2005
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 3/2005
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-005-1229-z

Other articles of this Issue 3/2005

Virchows Archiv 3/2005 Go to the issue