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Pediatric Surgery International

Published in:

01-03-2016 | Original Article

Gram-negative organisms in peritoneal dialysis peritonitis: an early indication for surgery in patients with haemolytic uraemic syndrome?

Authors: Rachel Harwood, David Wilkinson, Shweta Ramkumar, Gillian Humphrey

Published in: Pediatric Surgery International | Issue 3/2016

Abstract

Purpose

Haemolytic uraemic syndrome (HUS) is the commonest childhood cause of acute renal failure. Peritoneal dialysis peritonitis (PDP) is a well-recognised complication, with some children requiring surgical intervention (SI). The aim of this study is to determine whether the presence of enteric organisms in cases of PDP might predict the need for SI.

Methods

Retrospective, 5-year (2009–2014) case note review of all HUS cases requiring PD presenting to a single centre. Mann–Whitney U test was used for continuous non-parametric data and χ ² for categorical data.

Results

48 children required PD for HUS, 18/48 (38 %) developed PDP and of these 5/18 (28 %) required SI (subtotal colectomy n = 4, small bowel resection n = 1). Peritoneal fluid was cultured as part of the work-up for PDP. The presence of enteric organisms was associated with a 10.4 fold relative risk of requiring surgery (p = 0.02, 95 % CI 1.5–71.9), with 4/5 of these patients requiring surgery (median 17 days post-culture result). Only 1/13 patients not requiring surgery grew gram-negative bacteria.

Conclusion

The presence of enteric bacteria in patients with PDP significantly decreases the chances of successful conservative management. In these patients early involvement of the surgical team is essential with a low threshold for SI.

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Title: Gram-negative organisms in peritoneal dialysis peritonitis: an early indication for surgery in patients with haemolytic uraemic syndrome?
Authors: Rachel Harwood
David Wilkinson
Shweta Ramkumar
Gillian Humphrey
Publication date: 01-03-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 3/2016
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-015-3833-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gram-negative organisms in peritoneal dialysis peritonitis: an early indication for surgery in patients with haemolytic uraemic syndrome?

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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