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International Journal of Pediatric Endocrinology
Published in: International Journal of Pediatric Endocrinology 1/2010

Open Access 01-12-2011 | Review

Gonadotropin-Dependent Precocious Puberty: Neoplastic Causes and Endocrine Considerations

Authors: Matthew D. Stephen, Peter E. Zage, Steven G. Waguespack

Published in: International Journal of Pediatric Endocrinology | Issue 1/2010

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Abstract

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a delay in diagnosis may lead to adverse patient outcomes. The intent of the current paper is to review the neoplastic and developmental causes of gonadotropin-dependent precocious puberty. We discuss the common CNS lesions and human chorionic gonadotropin-secreting tumors that cause sexual precocity, review the relationship between therapeutic radiation and gonadotropin-dependent precocious puberty, and finally, provide an overview of the therapies available for height preservation in this unique patient population.
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Metadata
Title
Gonadotropin-Dependent Precocious Puberty: Neoplastic Causes and Endocrine Considerations
Authors
Matthew D. Stephen
Peter E. Zage
Steven G. Waguespack
Publication date
01-12-2011
Publisher
BioMed Central
Published in
International Journal of Pediatric Endocrinology / Issue 1/2010
Electronic ISSN: 1687-9856
DOI
https://doi.org/10.1155/2010/184502

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