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Indian Journal of Surgery

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01-12-2021 | Goiter | Original Article

Thyroid autotransplantation after total thyroidectomy in multi-nodular goiter—a case series analysis

Authors: Sherif Monib, Hany Habashy, Mohamed Ibrahim

Published in: Indian Journal of Surgery | Issue 6/2021

Abstract

Background

Following the success of parathyroid autotransplantation, thyroid autotransplantation was introduced, aiming to avoid or reduce the severity of post-thyroidectomy hypothyroidism in noncompliant patients.

Aim

While our primary aim was to assess the survival and function of heterotopic autotransplanted thyroid tissue after total thyroidectomy, our secondary aim was to establish a relationship between autotransplanted volume and euthyroid state.

Methods

We conducted a case series analysis, including 40 women diagnosed with multinodular goiter for whom total thyroidectomy was considered. Patients were randomized into two groups: group A (20 patients) who received 15 g and group B (20 patients) who received 10 g of healthy non-nodular thyroid tissue.

Survival and function of heterotopic autotransplanted thyroid tissue was assessed by hormonal profile and thigh ultrasound scan (site of autotransplanted thyroid graft) 2, 6, and 12 months postoperatively.

Results

We have included 40 ladies divided into two groups: group A < 50 years and group B > 50 years. There was no statistically significant difference between group A and group B regarding radioactive iodine uptake after the 2nd, 6th, and 12th months. There was a statistically significant difference between results after the 2nd, 6th, and 12th months regarding free T3 (FT3; tri-iodothyronine), free T4 (FT4; thyroxine), thyroid-stimulating hormone, and pulse (p ≤ 0.001). The study revealed a highly statistically significant difference between the 2nd, 6th, and 12th months in FT3, FT4, and TSH levels and pulse (p ≤ 0.001) as well as highly statistically significant difference between group A and group B regarding FT3 and FT4 after the 2nd, 6th, and 12th months (p ≤ 0.001) (Tables 2 and 3).

Autotransplanted thyroid tissue processing and injection time range was 18–20 min, and none of the patients had immediate or delayed complications.

Conclusion

We found the procedure to be safe, successful, and not time-consuming; we also found that better results were achieved when larger volumes were implanted in younger patients.

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Title: Thyroid autotransplantation after total thyroidectomy in multi-nodular goiter—a case series analysis
Authors: Sherif Monib
Hany Habashy
Mohamed Ibrahim
Publication date: 01-12-2021
Publisher: Springer India
Keywords: Goiter
Thyroidectomy
Thyroidectomy
Multinodular Goiter
Published in: Indian Journal of Surgery / Issue 6/2021
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI: https://doi.org/10.1007/s12262-021-02719-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Thyroid autotransplantation after total thyroidectomy in multi-nodular goiter—a case series analysis

Abstract

Background

Aim

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Aim

Methods

Results

Conclusion

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