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01-04-2013 | Editorial

Goal-directed fluid resuscitation in acute pancreatitis: shedding light on the penumbra by dynamic markers of preload?

Authors: Wolfgang Huber, Manu L. N. G. Malbrain

Published in: Intensive Care Medicine | Issue 4/2013

Excerpt

Acute pancreatitis (AP) is a potentially life-threatening disease with increasing incidence in Western countries. Severe AP (SAP) results in mortality of up to 42 % [1‐3]. Several recent studies have demonstrated improved early prediction of severity using a new scoring system (bedside index of severity in acute pancreatitis, BISAP) [4] or single parameters including elevated blood glucose [5], blood urea nitrogen (BUN) [4] and haematocrit [6, 7]. Regarding therapeutic consequences, the association between elevated haematocrit and poor outcome is particularly of interest [6, 7]. These data suggest that impaired macro- and microcirculation with elevated BUN, decreased mean arterial pressure (MAP) and increased lactate [2] are crucial pathomechanisms for the development of SAP promoting pancreatic inflammation, particularly in parts of the pancreas with critical perfusion called the “penumbra” [3]. …

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Title: Goal-directed fluid resuscitation in acute pancreatitis: shedding light on the penumbra by dynamic markers of preload?
Authors: Wolfgang Huber
Manu L. N. G. Malbrain
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 4/2013
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-012-2783-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Goal-directed fluid resuscitation in acute pancreatitis: shedding light on the penumbra by dynamic markers of preload?

Excerpt

Keynote webinar | Spotlight on medication adherence

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