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Indian Journal of Otolaryngology and Head & Neck Surgery

08-05-2024 | Glossectomy | Original Article

Clinicopathological Characteristics, Prognostic Factors, and Treatment Outcomes of Patients with Oral Tongue Squamous Cell Carcinoma Treated with Glossectomy: A Tertiary Oncology Center Experience

Authors: Hadi A. Al-Hakami, Atheer Ali Al-Talhi, Bassam AlRajhi, Abdulrahman E. Alghamdi, Naif M. Aloufi, Zyad E. Raffah, Mohammad A. Alshareef, Mohammed Al-Garni

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery

Abstract

Oral tongue squamous cell cancer (OTSCC) is one of the most prevalent cancers worldwide and incidence increases with age. An alarming increase in the incidence of OTSCC in the younger age group. This study aimed to explore clinical and histopathological characteristics, survival, and other post-surgical outcomes in patients with OTSCC treated with glossectomy through the Department of Otolaryngology-Head & Neck Surgery at the Ministry of National Guard Health Affairs (MNGHA) within our study period. This is a retrospective study carried out through the collection and analysis of data from medical charts of 56 patients with oral tongue cancer who were treated by glossectomy. Treatment was initiated from January 2010 to December 2021. Patient characteristics, tumor characteristics, treatment modality, failure patterns, and survival rates were collected and analyzed. At diagnosis, 62.5% were tobacco smokers, 46.8% had poor dental hygiene, and 76.8% had ulcerative lesions. Furthermore, 33 cases presented with early-stage clinical disease and 23 cases with advanced stage. The median follow-up was 54 months, 28 patients (50%) were free for 3–5 years. Patients who were free on 5-year follow-up had a significantly higher percentage of negative lymphovascular and perineural invasion (p < 0.05). Additionally, 12 patients (21.4%) had developed recurrence. Mortality in all cases was 30.3, but mortality-related cancer was 19.6%. Locoregional failure remains the main cause of treatment failure in resectable OTSCC. Pathological T-stage, N-stage, LVI, PNI, ECE, and LNR are all considered strong prognostic factors.

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Title: Clinicopathological Characteristics, Prognostic Factors, and Treatment Outcomes of Patients with Oral Tongue Squamous Cell Carcinoma Treated with Glossectomy: A Tertiary Oncology Center Experience
Authors: Hadi A. Al-Hakami
Atheer Ali Al-Talhi
Bassam AlRajhi
Abdulrahman E. Alghamdi
Naif M. Aloufi
Zyad E. Raffah
Mohammad A. Alshareef
Mohammed Al-Garni
Publication date: 08-05-2024
Publisher: Springer India
Keywords: Glossectomy
Oral Cancer
Oral Cavity Carcinoma
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-024-04720-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinicopathological Characteristics, Prognostic Factors, and Treatment Outcomes of Patients with Oral Tongue Squamous Cell Carcinoma Treated with Glossectomy: A Tertiary Oncology Center Experience

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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