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European Journal of Nuclear Medicine and Molecular Imaging

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01-10-2021 | Glomerulonephritis | Original Article

Value of [⁶⁸Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Authors: Yue Zhou, Xin Yang, Huipan Liu, Wenbin Luo, Hanxiang Liu, Taiyong Lv, Junzheng Wang, Jianhua Qin, Santao Ou, Yue Chen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2021

Abstract

Purpose

Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [⁶⁸Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04, which specifically images fibroblast activation protein (FAP) expression for renal fibrosis.

Methods

All patients underwent renal puncture before receiving [⁶⁸Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [⁶⁸Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations. The data obtained were analyzed.

Results

The [⁶⁸Ga]Ga-FAPI-04 PET/CT examination results demonstrated that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe fibrosis was 3.92 ± 1.50, 5.98 ± 1.6, and 7.67 ± 2.23, respectively.

Conclusion

Compared with renal puncture examination, non-invasive imaging of FAP expression through [⁶⁸Ga]Ga-FAPI-04 PET/CT quickly demonstrates bilateral kidney conditions with high sensitivity. [⁶⁸Ga]Ga-FAPI-04 PET/CT can facilitate the evaluation of disease progression, diagnosis, and the development of a treatment plan.

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Title: Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis
Authors: Yue Zhou
Xin Yang
Huipan Liu
Wenbin Luo
Hanxiang Liu
Taiyong Lv
Junzheng Wang
Jianhua Qin
Santao Ou
Yue Chen
Publication date: 01-10-2021
Publisher: Springer Berlin Heidelberg
Keyword: Glomerulonephritis
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05343-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Value of [⁶⁸Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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