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Current Oncology Reports

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04-04-2024 | Glioma | REVIEW

Perioperative Neurocognitive Function in Glioma Surgery

Authors: Kyle R. Noll, Mariana Bradshaw, David Sheppard, Jeffrey S. Wefel

Published in: Current Oncology Reports | Issue 5/2024

Abstract

Purpose of Review

This review provides a concise overview of the recent literature regarding preoperative and postoperative neurocognitive functioning (NCF) in patients with glioma. Brief discussion also covers contemporary intraoperative brain mapping work, with a focus on potential influence of mapping upon NCF outcomes following awake surgery.

Recent Findings

Most patients with glioma exhibit preoperative NCF impairment, with severity varying by germ line and tumoral genetics, tumor grade, and lesion location, among other characteristics. Literature regarding postoperative NCF changes is mixed, though numerous studies indicate a majority of patients exhibit immediate and short-term worsening. This is often followed by recovery over several months; however, a substantial portion of patients harbor persisting declines. Decline appears related to surgically-induced structural and functional brain alterations, both local and distal to the tumor and resection cavity. Importantly, NCF decline may be mitigated to some extent by intraoperative brain mapping, including mapping of both language-mediated and nonverbal functions.

Summary

Research regarding perioperative NCF in patients with glioma has flourished over recent years. While this has increased our understanding of contributors to NCF and risk of decline associated with surgical intervention, more work is needed to better preserve NCF throughout the disease course.

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Title: Perioperative Neurocognitive Function in Glioma Surgery
Authors: Kyle R. Noll
Mariana Bradshaw
David Sheppard
Jeffrey S. Wefel
Publication date: 04-04-2024
Publisher: Springer US
Keywords: Glioma
Glioma
Glioma
Published in: Current Oncology Reports / Issue 5/2024
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-024-01522-9

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