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Cancer Cell International
Published in: Cancer Cell International 1/2022

Open Access 01-12-2022 | Glioblastoma | Review

Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers

Authors: Mohsen Karami Fath, Nastaran Karimfar, Andarz Fazlollahpour Naghibi, Shahriyar Shafa, Melika Ghasemi Shiran, Mehran Ataei, Hossein Dehghanzadeh, Mohsen Nabi Afjadi, Tahereh Ghadiri, Zahra Payandeh, Vahideh Tarhriz

Published in: Cancer Cell International | Issue 1/2022

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Abstract

Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated extrachromosomal circular DNA has been proposed to endanger human health and speed up the progression of cancer. The amplification of ecDNA has raised the oncogene copy number in numerous malignancies according to whole-genome sequencing on distinct cancer types. The unusual structure and function of ecDNA, and its potential role in understanding current cancer genome maps, make it a hotspot to study tumor pathogenesis and evolution. The discovery of the basic mechanisms of ecDNA in the emergence and growth of malignancies could lead researchers to develop new cancer therapies. Despite recent progress, different aspects of ecDNA require more investigation. We focused on the features, and analyzed the bio-genesis, and origin of ecDNA in this review, as well as its functions in neuroblastoma and glioma cancers.
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Metadata
Title
Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers
Authors
Mohsen Karami Fath
Nastaran Karimfar
Andarz Fazlollahpour Naghibi
Shahriyar Shafa
Melika Ghasemi Shiran
Mehran Ataei
Hossein Dehghanzadeh
Mohsen Nabi Afjadi
Tahereh Ghadiri
Zahra Payandeh
Vahideh Tarhriz
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-022-02617-8

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