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Graefe's Archive for Clinical and Experimental Ophthalmology

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Open Access 31-03-2023 | Glaucoma | Glaucoma

Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy

Authors: Mina Okuda, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 9/2023

Abstract

Purpose

We have previously demonstrated that prolonged use of glaucoma medications was associated with a poor surgical outcome of ab interno trabeculotomy (µTLO). Given that almost all types of glaucoma eye drop either enhance the drainage through the uveoscleral pathway or reduce aqueous humor production, we hypothesized that prolonged use of these medications might cause disuse atrophy of the conventional pathway. In contrast, ripasudil increases the conventional outflow and eventually shows a favorable outcome of µTLO. This study aimed to evaluate the effect of ripasudil use on µTLO outcomes.

Method

The medical charts of 218 patients who underwent µTLO were analyzed retrospectively. We compared the 1-year outcome between ripasudil users versus nonusers by using propensity score matching. We set the covariates as age, sex, glaucoma types, preoperative intraocular pressure (IOP), the mean deviation values of visual field tests, the presence or absence of concomitant cataract surgery, trabecular meshwork incision range, the presence or absence of any glaucoma medication except ripasudil and duration of glaucoma medical therapy. Success was defined as a postoperative IOP between 5 and 21 mmHg, a ≥ 20% IOP reduction from baseline, and no additional glaucoma surgery at postoperative 1 year.

Result

Fifty-seven patients each were allocated to the ripasudil users or nonusers. The 1-year success rates were 74% in ripasudil users and 51% in nonusers (p = 0.01). Kaplan‒Meier survival curves also showed that the ripasudil users had a higher survival distribution (p = 0.01).

Conclusion

The patients who took ripasudil showed a favorable 1-year outcome of µTLO.

Available only for authorised users

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Title: Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy
Authors: Mina Okuda
Sotaro Mori
Kaori Ueda
Mari Sakamoto
Sentaro Kusuhara
Yuko Yamada-Nakanishi
Makoto Nakamura
Publication date: 31-03-2023
Publisher: Springer Berlin Heidelberg
Keywords: Glaucoma
Trabeculotomy
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 9/2023
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-023-06040-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy

Abstract

Purpose

Method

Result

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Result

Conclusion

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