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Graefe's Archive for Clinical and Experimental Ophthalmology

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15-07-2022 | Glaucoma | Glaucoma

The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma

Authors: Zakieh Vahedian, Ghasem Fakhraie, Mehrnoosh Ghasemi, Ali Azimi, Seyed Mehdi Tabatabaei

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2022

Abstract

Purpose

To compare outer macular and retinal thickness in the circumpapillary area in unilateral advanced glaucomatous eyes to the normal or mild glaucomatous fellow eyes.

Methods

Seventy-eight eyes of 39 patients with unilateral advanced glaucoma (mean deviation (MD) worse than –12.00 dB based on visual field 24-2) were included in this cross-sectional study as the cases. The healthy or mild glaucomatous fellow eyes were enrolled as the control group. All eyes underwent optical coherence tomography of the macula and circumpapillary retina by Topcon DRI Triton (Topcon, Tokyo, Japan). Ganglion cell layer 2+ was considered as the inner retina. Total retinal thickness minus the thickness of the inner retina was considered as the outer retina. Comparison between groups was done by paired-sample sign test. The correlation between structural and functional parameters was evaluated by a partial correlation coefficient.

Results

Seventeen (43.6%), 15 (38.5%), and 7 (17.9%) patients had pseudoexfoliation, primary angle-closure, and primary open-angle glaucoma, respectively. The mean age was 62.69 ± 12.00 years. Thirty-three (84.6%) patients were male. The outer retinal thickness in the circumpapillary area was higher in temporal, superior, and inferior quadrants (p < 0.05). The outer macula in different parafoveal and perifoveal quadrants was also thicker (p < 0.05). Average outer parafoveal thickness in the case group had a significant negative correlation with MD (r = –0.339; p = 0.035).

Conclusion

Advanced glaucomatous eyes had a thicker outer retina in the macula and circumpapillary area. There was a significant negative correlation between outer perifoveal thickness and MD.

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Title: The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma
Authors: Zakieh Vahedian
Ghasem Fakhraie
Mehrnoosh Ghasemi
Ali Azimi
Seyed Mehdi Tabatabaei
Publication date: 15-07-2022
Publisher: Springer Berlin Heidelberg
Keyword: Glaucoma
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2022
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-022-05756-w

2024 ASCO Annual Meeting

Springer Medicine

The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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