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International Ophthalmology
Published in: International Ophthalmology 4/2020

01-04-2020 | Glaucoma | Original Paper

Potentially inappropriate prescriptions of anticholinergic medications in patients with closed-angle glaucoma

Authors: Luis Fernando Valladales-Restrepo, Jorge Enrique Machado-Alba

Published in: International Ophthalmology | Issue 4/2020

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Abstract

Purpose

Glaucoma is the leading cause for blindness after cataracts worldwide. The aim was to identify anticholinergic drugs prescribed to patients diagnosed with closed-angle glaucoma in Colombia.

Methods

This cross-sectional study identified the prescribing patterns of cholinergic antagonists related to the increased intraocular pressure in patients diagnosed with closed-angle glaucoma from a Colombian database. The Anticholinergic Drug Scale was used to quantify the anticholinergic burden.

Results

We identified 1958 patients with closed-angle glaucoma, with a mean age of 70.5 ± 10.3 years, 72.9% of whom were women. Cholinergic antagonists were prescribed in at least 32.4% of cases. An age range between 75 and 84 years (odds ratio (OR) 2.35, 95% confidence interval (CI) 1.366–4.059) and being aged 85 years or older (OR 3.40, 95% CI 1.809–6.425) were associated with a greater probability of receiving an anticholinergic burden between 1 and 2 points. Females (OR 1.54, 95% CI 1.096–2.181) had a higher probability of receiving an anticholinergic burden ≥ 3 points. Interactions between antiglaucoma medications and anticholinergic treatments were identified in 32.1% of the patients.

Conclusions

Most patients were prescribed multiple antiglaucoma medications, reflecting a large number of potentially inappropriate prescriptions, with anticholinergic drugs, related to the increased intraocular pressure.
Literature
1.
Jonas JB, Aung T, Bourne RR et al (2017) Glaucoma. Lancet 390(10108):2183–2193CrossRef
2.
3.
Zhao Y, Fu JL, Li YL et al (2015) Epidemiology and clinical characteristics of patients with glaucoma: an analysis of hospital data between 2003 and 2012. Indian J Ophthalmol 63(11):825–831CrossRef
4.
Sawaguchi S, Sakai H, Iwase A et al (2012) Prevalence of primary angle closure and primary angle-closure glaucoma in a southwestern rural population of Japan: the Kumejima study. Ophthalmology 119(6):1134–1142CrossRef
5.
Hohn R, Nickels S, Schuster AK et al (2018) Prevalence of glaucoma in Germany: results from the Gutenberg Health Study. Graefes Arch Clin Exp Ophthalmol 256(9):1695–1702CrossRef
6.
Kolko M, Horwitz A, Thygesen J et al (2015) The prevalence and incidence of glaucoma in Denmark in a fifteen year period: a nationwide study. PLoS ONE 10(7):e0132048CrossRef
7.
Tham YC, Li X, Wong TY et al (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121(11):2081–2090CrossRef
8.
Ko YC, Liu CJ, Hsu WM et al (2015) Determinants and characteristics of angle-closure disease in an elderly Chinese population. Ophthalmic Epidemiol 22(2):109–115CrossRef
9.
Sun X, Dai Y, Chen Y et al (2017) Primary angle closure glaucoma: what we know and what we don’t know. Prog Retin Eye Res 57:26–45CrossRef
10.
Razeghinejad MR, Myers JS, Katz LJ (2011) Iatrogenic glaucoma secondary to medications. Am J Med 124(1):20–25CrossRef
11.
12.
Ah-Kee EY, Egong E, Shafi A et al (2015) A review of drug-induced acute angle closure glaucoma for non-ophthalmologists. Qatar Med J 1:6CrossRef
13.
Vélez-Gómez MC, Vásquez-Trespalacios EM (2018) Adherence to topical treatment of glaucoma, risk and protective factors: a review. Arch Soc Esp Oftalmol 93(2):87–92CrossRef
14.
Nishtala PS, Salahudeen MS, Hilmer SN (2016) Anticholinergics: theoretical and clinical overview. Expert Opin Drug Saf 15(6):753–768CrossRef
15.
Collamati A, Martone AM, Poscia A et al (2016) Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence. Aging Clin Exp Res 28(1):25–35CrossRef
16.
Carnahan RM, Lund BC, Perry PJ et al (2006) The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol 46(12):1481–1486CrossRef
17.
Fea AM, Dallorto L, Lavia C et al (2018) Long-term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma patients. Clin Exp Ophthalmol 46(3):232–239CrossRef
18.
Lai JS, Liu DT, Tham CC et al (2001) Epidemiology of acute primary angle-closure glaucoma in the Hong Kong Chinese population: prospective study. Hong Kong Med J 7(2):118–123PubMed
19.
20.
Rieger-Reyes C, Rubio-Galán FJ (2013) Glaucoma: pharmacological implications. Semergen 39(1):26–33CrossRef
21.
Conlon R, Saheb H, Ahmed II (2017) Glaucoma treatment trends: a review. Can J Ophthalmol 52(1):114–124CrossRef
22.
Kim CY, Park KH, Ahn J et al (2017) Treatment patterns and medication adherence of patients with glaucoma in South Korea. Br J Ophthalmol 101(6):801–807CrossRef
23.
Chassid O, Epstein I, Sharabi-Nov A et al (2018) Prevalence of glaucoma in the Israeli Arab population. Int J Ophthalmol 11(1):163–165PubMedPubMedCentral
24.
Machado-Alba J, Hoyos-Soto V (2014) Frequency of coprescription and potential risk of bronchospasm in colombian patients users of topical antiglaucomatous betablockers and bronchodilators. Vitae 21:107–113
25.
Kalouda P, Keskini C, Anastasopoulos E et al (2017) Achievements and limits of current medical therapy of glaucoma. Dev Ophthalmol 59:1–14CrossRef
26.
Bower T, Samek DA, Mohammed A et al (2018) Systemic medication usage in glaucoma patients. Can J Ophthalmol 53(3):242–245CrossRef
27.
Gerretsen P, Pollock BG (2011) Drugs with anticholinergic properties: a current perspective on use and safety. Expert Opin Drug Saf 10(5):751–765CrossRef
28.
O’Mahony D, O’Sullivan D, Byrne S et al (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44(2):213–218CrossRef
29.
Badhu BP, Bhattarai B, Sangraula HP (2013) Drug-induced ocular hypertension and angle-closure glaucoma. Asia Pac J Ophthalmol (Phila) 2(3):173–176CrossRef
30.
Khurana AK, Khurana B, Khurana AK (2012) Drug-induced angle-closure glaucoma. J Curr Glaucoma Pract 6(1):6–8CrossRef
Metadata
Title
Potentially inappropriate prescriptions of anticholinergic medications in patients with closed-angle glaucoma
Authors
Luis Fernando Valladales-Restrepo
Jorge Enrique Machado-Alba
Publication date
01-04-2020
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 4/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-019-01241-2

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