Top

International Ophthalmology

Published in:

01-03-2022 | Glaucoma | Original Paper

The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment

Authors: Numan Eraslan, Eren Ekici, Osman Celikay

Published in: International Ophthalmology | Issue 3/2022

Abstract

Purpose

To study the effect of topical bimatoprost on the corneal optical density values using a dual Scheimpflug Placido analysis system.

Methods

This longitudinal case–control study included 18 patients with newly diagnosed primary open-angle glaucoma who received topical bimatoprost as a first-line treatment and 20 healthy individuals (age and sex-matched controls). Corneal densitometry data were obtained using the dual Scheimpflug analyzer at pre-treatment and 1st, 6th, 12th, 18th months of post-treatment. Repeated measures of ANOVA and Pearson correlation tests were used for statistical analysis.

Results

There were statistically significant differences between pre-treatment and post-treatment 1st and 6th months corneal densitometry values (p < 0.001, p = 0.007, respectively). However, there was no statistically significant difference between the post-treatment 12th and 18th months (p > 0.05). Corneal densitometry values decreased during the 1st month. Intraocular pressure (IOP) differences were statistically significant between baseline and 1 month after treatment (P < 0.001), however not statistically significant between the 1st and 6th, 6th and 12th, 12th and 18th months after treatment (p > 0.05, for all). Corneal densitometry was not correlated with IOP (r = − 0.037, p = 0.44). In the control group, there was no statistically significant difference between baseline and post-baseline 18th-month corneal densitometry measurements (p > 0.05).

Conclusions

Topical bimatoprost administration might result in a decrease in corneal densitometry measurement. It is of clinical importance that topical bimatoprost administration can affect corneal transparency and cause a possible alteration in corneal properties.

Quigley HA, Broman AT (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br J Opthalmol 90(3):262–267CrossRef

Tham Y-C, Li X, Wong TY et al (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Opthalmology 121(11):2081–2090CrossRef

Weinreb RN, Robinson MR, Dibas M et al (2020) Matrix metalloproteinases and glaucoma treatment. J Ocul Pharmacol Ther 36(4):208–228CrossRef

Lee AJ, McCluskey P (2010) Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension. Clin Opthalmol 4:741

Park MH, Cho K, Moon JI (2009) The effects of prostaglandin analogues on the corneal thickness. J Korean Ophthalmol Soc 50:565–571CrossRef

Toris CB, B’Ann TG, Kaufman PL (2008) Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv Opthalmol 53:S107–S120CrossRef

Savini G, Carbonelli M, Barboni P et al (2011) Repeatability of automatic measurements performed by a dual Scheimpflug analyzer in unoperated and post-refractive surgery eyes. J Cataract Refract Surg 37(2):302–309CrossRef

Group CZ (2020) Product Specs; GALILEI™ Dual Scheimpflug Analyzer. v. 2020

Otri AM, Fares U, Al-Aqaba MA, Dua HS (2012) Corneal densitometry as an indicator of corneal health. Opthalmology 119(3):501–508CrossRef

10.

Shen Y, Han T, Jhanji V et al (2019) Correlation between corneal topographic, densitometry and biomechanical parameters in keratoconus eyes. Transl Vis Sci Technol 8(3):12CrossRef

11.

Alnawaiseh M, Zumhagen L, Zumhagen S et al (2016) Corneal densitometry as a novel technique for monitoring amiodarone therapy. Opthalmology 123(11):2294–2299CrossRef

12.

Blanco A, Bagnasco L, Bagnis A et al (2017) European Glaucoma Society Terminology and Guidelines for Glaucoma, —Chapter 2: classification and terminology supported by the EGS Foundation: Part 1: foreword; introduction; glossary; Chapter 2 classification and terminology. 101:73–127

13.

Dhubhghaill SN, Rozema JJ, Jongenelen S et al (2014) Normative values for corneal densitometry analysis by scheimpflug optical assessment. Invest Opthalmol Vis Sci 55(1):162–168CrossRef

14.

Doucette LP, Walter MA (2017) Prostaglandins in the eye: function, expression, and roles in glaucoma. Opthalmic Genet 38(2):108–116CrossRef

15.

Brubaker RF (2001) Mechanism of action of bimatoprost (Lumgian™). Surv Opthalmol 45:S347–S351CrossRef

16.

Stewart WC, Konstas AG, Nelson LA, Kruft B (2008) Meta-analysis of 24-h intraocular pressure studies evaluating the efficacy of glaucoma medicines. Opthalmology 115(7):1117–1122CrossRef

17.

Dubiner H, Cooke D, Dirks M et al (2001) Efficacy and safety of bimatoprost in patients with elevated intraocular pressure: a 30-day comparison with latanoprost. Surv Opthalmol 45:S353–S360CrossRef

18.

Gandolfi S, Simmons ST, Sturm R et al (2001) Three-month comparison of bimatoprost and latanoprost in patients with glaucoma and ocular hypertension. Adv Ther 18(3):110–121CrossRef

19.

Walters TR, DuBiner HB, Carpenter SP et al (2004) 24-h IOP control with once-daily bimatoprost, timolol gel-forming solution, or latanoprost: a 1-month, randomized, comparative clinical trial. Surv Opthalmol 49(2):S26-35CrossRef

20.

Noecker RS, Dirks MS, Choplin NT et al (2003) A 6-month randomized clinical trial comparing the intraocular pressure-lowering efficacy of bimatoprost and latanoprost in patients with ocular hypertension or glaucoma. Am J Opthalmol 135(1):55–63CrossRef

21.

Zhong Y, Shen X, Yu J et al (2011) The comparison of the effects of latanoprost, travoprost, and bimatoprost on central corneal thickness. Cornea 30(8):861–864CrossRef

22.

Arcieri E, Pierre Filho P, Wakamatsu T, Costa VJE (2008) The effects of prostaglandin analogues on the blood aqueous barrier and corneal thickness of phakic patients with primary open-angle glaucoma and ocular hypertension. Eye (Lond) 22(2):179–183CrossRef

23.

Hatanaka M, Vessani RM, Elias IR et al (2009) The effect of prostaglandin analogs and prostamide on central corneal thickness. J Ocul Pharmacol Ther 25(1):51–54CrossRef

24.

Bafa M, Georgopoulos G, Mihas C et al (2011) The effect of prostaglandin analogues on central corneal thickness of patients with chronic open-angle glaucoma: a 2-year study on 129 eyes. Acta Opthalmol 89(5):448–451CrossRef

25.

Korey M, Gieser D, Kass MA et al (1982) Central corneal endothelial cell density and central corneal thickness in ocular hypertension and primary open-angle glaucoma. Am J Opthalmol 94(5):610–616CrossRef

26.

Iester M, Telani S, Brusini P et al (2013) Central corneal thickness and glaucoma treatment: an Italian multicenter cross-sectional study. J Ocul Pharmacol Ther 29(5):469–473CrossRef

27.

Wan Z, Woodward DF, Cornell CL et al (2007) Bimatoprost, prostamide activity, and conventional drainage. Invest Opthalmol Vis Sci 48(9):4107–4115CrossRef

28.

Sen E, Inanc M, Elgin U (2019) The effect of topical latanoprost on corneal clarity; 1-year prospective study. Cutan Ocul Toxicol 38(3):253–257CrossRef

29.

Bergonzi C, Giani A, Blini M et al (2010) Evaluation of prostaglandin analogue effects on corneal keratocyte density using scanning laser confocal microscopy. J Glaucoma 19(9):617–621CrossRef

30.

Wu N, Chen Y, Yu X et al (2016) Changes in corneal biomechanical properties after long-term topical prostaglandin therapy. PLoS One 11(5):e0155527CrossRef

31.

Nakagawa S, Usui T, Yokoo S et al (2012) Toxicity evoluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets. Invest Opthalmol Vis Sci 53:5154–8180CrossRef

32.

Wensheng C, Nuo D, Caihong H et al (2014) Corneal alterations induced by topical application of commercial latanoprost, travoprost and bimatoprost in rabbit. PLoS One 9(3):e89205CrossRef

33.

Huang J, Ding X, Savini G et al (2014) Central and midperipheral corneal thickness measured with Scheimpflug imaging and optical coherence tomography. PLoS One 9(5):e98316CrossRef

34.

Rafii AB, Motevasseli T, Yazdizadeh F et al (2017) Comparision between two Scheimpflug anterior segment analyzers. J Ophthalmic Vis Res 12(1):23–29CrossRef

Title: The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment
Authors: Numan Eraslan
Eren Ekici
Osman Celikay
Publication date: 01-03-2022
Publisher: Springer Netherlands
Keywords: Glaucoma
Bimatoprost
Published in: International Ophthalmology / Issue 3/2022
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-021-02035-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 3/2022

Fixation stability improvement after occlusion treatment for severe amblyopia

Angle-supported intraocular lens versus scleral-sutured posterior chamber intraocular lens in post-cataract surgery aphakic patients: two-year follow-up cost-effectiveness analysis

Associated risk factors of postoperative pain after glaucoma surgery: a prospective study

Comparison of obstructive sleep apnea syndrome and keratoconus patients on elevation maps

Correction to: Detection of COVID-19 in tears of ICU-admitted patients with SARS-CoV-2 infection

Testing the eligibility of glaucoma patients for potential gene therapy among a clinic population