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Current Oral Health Reports
Published in: Current Oral Health Reports 1/2020

01-03-2020 | Gingival Diseases | Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis

Authors: George Hajishengallis, Patricia I. Diaz

Published in: Current Oral Health Reports | Issue 1/2020

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Abstract

Purpose of Review

This review summarizes mechanisms by which Porphyromonas gingivalis interacts with community members and the host so that it can persist in the periodontium under inflammatory conditions that drive periodontal disease.

Recent Findings

Recent advances indicate that, in great part, the pathogenicity of P. gingivalis is dependent upon its ability to establish residence in the subgingival environment and to subvert innate immunity in a manner that uncouples the nutritionally favorable (for the bacteria) inflammatory response from antimicrobial pathways. While the initial establishment of P. gingivalis is dependent upon interactions with early colonizing bacteria, the immune subversion strategies of P. gingivalis in turn benefit co-habiting species.

Summary

Specific interspecies interactions and subversion of the host response contribute to the emergence and persistence of dysbiotic communities and are thus targets of therapeutic approaches for the treatment of periodontitis.
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Metadata
Title
Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis
Authors
George Hajishengallis
Patricia I. Diaz
Publication date
01-03-2020
Publisher
Springer International Publishing
Published in
Current Oral Health Reports / Issue 1/2020
Electronic ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-020-00249-3

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