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Published in: Child's Nervous System 3/2019

01-03-2019 | Case Report

Giant cell tumor of the eleventh thoracic vertebra in a pediatric patient: an interesting case report and comprehensive literature review

Authors: Kadir Oktay, Ebru Guzel, Serkan Simsek, Aslan Guzel

Published in: Child's Nervous System | Issue 3/2019

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Abstract

Introduction

Giant cell tumors of the mobile spinal column are very rare tumors, especially in the pediatric age group. Although they are benign tumors, they have locally aggressive growth pattern and high risk of recurrence.

Case presentation

We report a 15-year-old female patient with thoracic giant cell tumor who underwent percutaneous vertebroplasty and had cement extravasation into the spinal canal. Because of the deterioration of the patient’s neurological condition, total enbloc spondylectomy and cement excision were performed. She underwent instrumentation and fusion procedures in order to prevent spinal instability.

Conclusion

The main purpose of the treatment is gross total resection of the giant cell tumor. However, adjuvant methods such as denosumab should be added to the treatment protocol in patients who are older than 2 years old and can not undergo gross total resection due to tumor size and anatomic localization.
Literature
1.
go back to reference Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G (2008) Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol 134(9):969–978CrossRefPubMed Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G (2008) Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol 134(9):969–978CrossRefPubMed
2.
go back to reference Ben Nsir A, Ben Said I, Badri M, Boughamoura M, Jemel H (2015) Giant cell tumor of the sixth thoracic vertebra: case report. Turk Neurosurg 25(3):475–478PubMed Ben Nsir A, Ben Said I, Badri M, Boughamoura M, Jemel H (2015) Giant cell tumor of the sixth thoracic vertebra: case report. Turk Neurosurg 25(3):475–478PubMed
3.
go back to reference de Carvalho Cavalcante RA, Silva Marques RA, dos Santos VG, Sabino E, Fraga AC Jr, Zaccariotti VA, Arruda JB, Fernandes YB (2016) Lumbar spondylectomy for giant cell tumor after denosumab therapy. Spine (Phila Pa 1976) 41(3):E178–E182CrossRef de Carvalho Cavalcante RA, Silva Marques RA, dos Santos VG, Sabino E, Fraga AC Jr, Zaccariotti VA, Arruda JB, Fernandes YB (2016) Lumbar spondylectomy for giant cell tumor after denosumab therapy. Spine (Phila Pa 1976) 41(3):E178–E182CrossRef
4.
go back to reference Kajiwara D, Kamoda H, Yonemoto T, Iwata S, Ishii T, Tsukanishi T, Ohtori S, Yamazaki M, Okawa A (2016) Denosumab for treatment of a recurrent cervical giant-cell tumor. Asian Spine J 10(3):553–557CrossRefPubMedPubMedCentral Kajiwara D, Kamoda H, Yonemoto T, Iwata S, Ishii T, Tsukanishi T, Ohtori S, Yamazaki M, Okawa A (2016) Denosumab for treatment of a recurrent cervical giant-cell tumor. Asian Spine J 10(3):553–557CrossRefPubMedPubMedCentral
5.
go back to reference Sigwalt L, Bourgeois E, Eid A, Durand C, Griffet J, Courvoisier A (2016) A thoracic spinal bone giant cell tumor in a skeletally immature girl. A case report and literature review. Childs Nerv Syst 32(5):873–876CrossRefPubMed Sigwalt L, Bourgeois E, Eid A, Durand C, Griffet J, Courvoisier A (2016) A thoracic spinal bone giant cell tumor in a skeletally immature girl. A case report and literature review. Childs Nerv Syst 32(5):873–876CrossRefPubMed
6.
go back to reference Yonezawa N, Murakami H, Kato S, Takeuchi A, Tsuchiya H (2017) Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy. Eur Spine J 26(Suppl 1):236–242CrossRefPubMed Yonezawa N, Murakami H, Kato S, Takeuchi A, Tsuchiya H (2017) Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy. Eur Spine J 26(Suppl 1):236–242CrossRefPubMed
7.
go back to reference Elder BD, Sankey EW, Goodwin CR, Kosztowski TA, Lo SF, Bydon A, Wolinsky JP, Gokaslan ZL, Witham TF, Sciubba DM (2016) Surgical outcomes in patients with high spinal instability neoplasm score secondary to spinal giant cell tumors. Global Spine J 6(1):21–28CrossRefPubMed Elder BD, Sankey EW, Goodwin CR, Kosztowski TA, Lo SF, Bydon A, Wolinsky JP, Gokaslan ZL, Witham TF, Sciubba DM (2016) Surgical outcomes in patients with high spinal instability neoplasm score secondary to spinal giant cell tumors. Global Spine J 6(1):21–28CrossRefPubMed
8.
go back to reference Luksanapruksa P, Buchowski JM, Singhatanadgige W, Rose PC, Bumpass DB (2016) Management of spinal giant cell tumors. Spine J 16(2):259–269CrossRefPubMed Luksanapruksa P, Buchowski JM, Singhatanadgige W, Rose PC, Bumpass DB (2016) Management of spinal giant cell tumors. Spine J 16(2):259–269CrossRefPubMed
9.
go back to reference Charest-Morin R, Fisher CG, Varga PP, Gokaslan ZL, Rhines LD, Reynolds JJ, Dekutoski MB, Quraishi NA, Bilsky MH, Fehlings MG, Chou D, Germscheid NM, Luzzati A, Boriani S (2017) En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. Spine (Phila Pa 1976) 42(18):1383–1390CrossRef Charest-Morin R, Fisher CG, Varga PP, Gokaslan ZL, Rhines LD, Reynolds JJ, Dekutoski MB, Quraishi NA, Bilsky MH, Fehlings MG, Chou D, Germscheid NM, Luzzati A, Boriani S (2017) En bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. Spine (Phila Pa 1976) 42(18):1383–1390CrossRef
10.
go back to reference Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res (153):106–120 Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res (153):106–120
11.
go back to reference Boriani S, Bandiera S, Casadei R, Boriani L, Donthineni R, Gasbarrini A, Pignotti E, Biagini R, Scwab JH (2012) Giant cell tumor of the mobile spine: a review of 49 cases. Spine (Phila Pa 1976) 37(1):E37–E45CrossRef Boriani S, Bandiera S, Casadei R, Boriani L, Donthineni R, Gasbarrini A, Pignotti E, Biagini R, Scwab JH (2012) Giant cell tumor of the mobile spine: a review of 49 cases. Spine (Phila Pa 1976) 37(1):E37–E45CrossRef
12.
go back to reference Goldschlager T, Dea N, Boyd M, Reynolds J, Patel S, Rhines LD, Mendel E, Pacheco M, Ramos E, Mattei TA, Fisher CG (2015) Giant cell tumors of the spine: has denosumab changed the treatment paradigm? J Neurosurg Spine 22(5):526–533CrossRefPubMed Goldschlager T, Dea N, Boyd M, Reynolds J, Patel S, Rhines LD, Mendel E, Pacheco M, Ramos E, Mattei TA, Fisher CG (2015) Giant cell tumors of the spine: has denosumab changed the treatment paradigm? J Neurosurg Spine 22(5):526–533CrossRefPubMed
13.
go back to reference Qi L, Li C, Wang N, Lian H, Lian M, He B, MD BG (2018) Efficacy of percutaneous vertebroplasty treatment of spinal tumors: a meta-analysis. Medicine (Baltimore) 97(3):e9575CrossRef Qi L, Li C, Wang N, Lian H, Lian M, He B, MD BG (2018) Efficacy of percutaneous vertebroplasty treatment of spinal tumors: a meta-analysis. Medicine (Baltimore) 97(3):e9575CrossRef
14.
go back to reference Martin C, McCarthy EF (2010) Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature. Iowa Orthop J 30:69–75PubMedPubMedCentral Martin C, McCarthy EF (2010) Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature. Iowa Orthop J 30:69–75PubMedPubMedCentral
15.
go back to reference Alfawareh MD, Shah ID, Orief TI, Halawani MM, Attia WI, Almusrea KN (2015) Pediatric upper cervical spine giant cell tumor: case report. Global Spine J 5(4):e28–e33CrossRefPubMed Alfawareh MD, Shah ID, Orief TI, Halawani MM, Attia WI, Almusrea KN (2015) Pediatric upper cervical spine giant cell tumor: case report. Global Spine J 5(4):e28–e33CrossRefPubMed
16.
go back to reference Kim SC, Cho W, Chang U, Youn SM (2015) Clinical outcome of treatment for patients with giant cell tumor in spine. J Korean Neurosurg Soc 58(3):248–253CrossRefPubMedPubMedCentral Kim SC, Cho W, Chang U, Youn SM (2015) Clinical outcome of treatment for patients with giant cell tumor in spine. J Korean Neurosurg Soc 58(3):248–253CrossRefPubMedPubMedCentral
17.
go back to reference Ma Y, Li J, Pan J, Yan W, Huang Q, Liu T, Yang X, Yang C, Xu W, Wei H, Xiao J (2016) Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine. Eur Spine J 25(12):4033–4042CrossRefPubMed Ma Y, Li J, Pan J, Yan W, Huang Q, Liu T, Yang X, Yang C, Xu W, Wei H, Xiao J (2016) Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine. Eur Spine J 25(12):4033–4042CrossRefPubMed
Metadata
Title
Giant cell tumor of the eleventh thoracic vertebra in a pediatric patient: an interesting case report and comprehensive literature review
Authors
Kadir Oktay
Ebru Guzel
Serkan Simsek
Aslan Guzel
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 3/2019
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3980-x

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