Ghrelin and exercise: a possible virtuous circle

Excerpt

It is well known that exercise in itself has several benefits in terms of health and fitness [1, 2], as well as neural and cognitive effects [3], in both humans and laboratory animals. Food restriction and regular exercise are the two major established strategies for the prevention and treatment of obesity, which is currently recognized as a serious burden worldwide. However, obesity is often associated with physical inactivity and disrupted life rhythms, including binge and night eating [4], which makes the treatment of obesity more complicated and weight reduction less attainable. Although exercise is recommended for the purpose of weight reduction through the increment of energy expenditure, it is generally difficult for most obese subjects to continue regular exercise for long periods of time. Thus, it is important to explore the putative mechanisms for producing the motivation to perform and adhere to exercise, especially in obese subjects. …