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BMC Pregnancy and Childbirth

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Open Access 01-12-2020 | Gestational Diabetes | Research article

Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies

Authors: Esra Ozbasli, Ozguc Takmaz, Emine Karabuk, Mete Gungor

Published in: BMC Pregnancy and Childbirth | Issue 1/2020

Abstract

Background

If not detected and treated, gestational diabetes mellitus (GDM) can cause serious pregnancy complications such as macrosomia, preeclampsia, and fetal/neonatal mortality. Many studies have examined underlying contributing factors for GDM, including hypercoagulation. Factor XII (FXII) is a coagulation factor that increases throughout normal pregnancies, and we evaluated the relationship of GDM with FXII, FXIIa (activated FXII), and other coagulation parameter levels. GDM and macrosomia are closely related, but it is not known whether FXII could be an independent causal factor for macrosomia.

Methods

In this prospective study, blood samples were taken from 69 pregnant women at the time of term delivery to determine levels of FXII, FXIIa, and other coagulation parameters. Based on the results, pregnancies fell into GDM, non-diabetic with macrosomia (M), or healthy (C [control]).

Results

FXII concentration levels were significantly higher in GDM patients compared with the M and C groups. There were no significant differences when comparing FXIIa, activated partial thromboplastin time, prothrombin time (PT), and international normalized ratio. The GDM group saw a significant negative correlation between FXII concentrations and maternal pregestational body mass index (BMI) and BMI before delivery. In the M group, a positive correlation was observed between FXII concentrations and newborn weight and newborn weight percentile.

Conclusions

An increase in FXII levels was observed in patients with gestational diabetes. Associations between coagulation parameters and GDM should be further analyzed to define the mechanisms of GDM and possible treatment modalities.

Trial registration

Our study has been registered at clinicaltrials.gov (NCT03583216). Registered on July 11, 2018,

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Title: Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies
Authors: Esra Ozbasli
Ozguc Takmaz
Emine Karabuk
Mete Gungor
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Gestational Diabetes
Gestational Diabetes
Published in: BMC Pregnancy and Childbirth / Issue 1/2020
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-020-03455-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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