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Published in: The Journal of Headache and Pain 1/2012

Open Access 01-01-2012 | Original

Genotype–phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1

Authors: Anne Francke Christensen, Han Le, Malene Kirchmann, Jes Olesen

Published in: The Journal of Headache and Pain | Issue 1/2012

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Abstract

A large two-stage GWAS by Antilla et al. reported the minor allele of rs1835740 on 8q22.1 to be associated with common types of migraine. The objective of the present study was to determine the clinical correlate of the variant in migraine without aura (MO). Clinical data on 339 successfully genotyped MO patients (patients with attacks of migraine without aura and no attacks of migraine with aura) were obtained by an extensive validated semi-structured telephone interview performed by a physician or a trained senior medical student. Reliable, systematic and extensive data on symptoms, age of onset, attack frequencies and duration, relevant comorbidity, specific provoking factors including different hormonal factors in females, and effect and use of medication, both abortive and prophylactic, were thereby obtained. A comparison of carriers and non-carriers were performed. Comparison of homozygotes with heterozygotes was not performed as the number of homozygotes was too small for statistical purposes. Data from other MO populations in the GWAS by Antilla et al. were not included as phenotype and clinical data were obtained differently. While thousands of patients are needed to detect a genetic variant like rs1835740, 339 are sufficient to detect meaningful clinical differences. 136 of 339 patients were carriers of the variant, 15 were homozygous. Comparison of carriers with non-carriers showed no significant difference in any of the parameters studied. In conclusion, the rs1835740 variant has no significant influence on the clinical expression of MO.
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Metadata
Title
Genotype–phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1
Authors
Anne Francke Christensen
Han Le
Malene Kirchmann
Jes Olesen
Publication date
01-01-2012
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2012
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-011-0386-5

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