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Current Psychiatry Reports

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01-09-2017 | Genetic Disorders (F Goes, Section Editor)

Genetics of Schizophrenia: Ready to Translate?

Authors: Claire Foley, Aiden Corvin, Shigeki Nakagome

Published in: Current Psychiatry Reports | Issue 9/2017

Abstract

Purpose of Review

This is an era where we have significantly advanced the understanding of the genetic architecture of schizophrenia. In this review, we consider how this knowledge may translate into advances that will improve patient care.

Recent Findings

Large-scale genome-wide association studies (GWAS) have identified more than a hundred loci each making a small contribution to illness risk. Meta-analysis of copy number variants (CNVs) in the Psychiatric Genomics Consortium (PGC) dataset has confirmed that some variants have a moderate or large impact on risk, although these are rare in the population. Genome sequencing advances allow a much more comprehensive evaluation of genomic variation. We describe the key findings from whole exome studies to date. These studies are happening against a backdrop of growing understanding of the regulation and expression of genes and better functional tools to investigate molecular mechanisms in model systems.

Summary

We provide an overview of how recent approaches in schizophrenia genetics are converging and consider how they could impact on diagnostics, the development of personalized medicine, and drug discovery.

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Title: Genetics of Schizophrenia: Ready to Translate?
Authors: Claire Foley
Aiden Corvin
Shigeki Nakagome
Publication date: 01-09-2017
Publisher: Springer US
Published in: Current Psychiatry Reports / Issue 9/2017
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-017-0807-5

At a glance: The STEP trials

Springer Medicine

Genetics of Schizophrenia: Ready to Translate?

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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