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Journal of NeuroVirology
Published in: Journal of NeuroVirology 4/2017

01-08-2017 | Review

Genetics of HIV-associated sensory neuropathy and related pain in Africans

Authors: Huguette Gaelle Ngassa Mbenda, Antonia Wadley, Zane Lombard, Catherine Cherry, Patricia Price, Peter Kamerman

Published in: Journal of NeuroVirology | Issue 4/2017

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Abstract

Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV. However, recent studies performed in Southern African populations have identified genes displaying potential as genetic markers for HIV-SN and HIV-SN-associated pain in Africans. Here, we review the published studies to describe current knowledge of genetic risk factors for this disease in Africa.
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Metadata
Title
Genetics of HIV-associated sensory neuropathy and related pain in Africans
Authors
Huguette Gaelle Ngassa Mbenda
Antonia Wadley
Zane Lombard
Catherine Cherry
Patricia Price
Peter Kamerman
Publication date
01-08-2017
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 4/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-017-0532-1

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