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Current Atherosclerosis Reports
Published in: Current Atherosclerosis Reports 3/2010

01-05-2010

Genetics of Atherothrombosis and Thrombophilia

Authors: Anders Mälarstig, Anders Hamsten

Published in: Current Atherosclerosis Reports | Issue 3/2010

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Abstract

Thrombosis in the arterial or venous vascular systems is preceded by a complex interplay between environmental and genetic factors, and it is the underlying cause of several common complex diseases. The genome-wide association approach has proved successful in identifying loci associated with cardiovascular disease and related risk factors. However, much work remains to define the culprit genes and causal variants as well as the mechanisms whereby they influence disease development and progression. In-depth studies of previously identified disease-associated loci are expected to improve our understanding of the pathophysiology of cardiovascular disease and identify novel targets for treatment. Here, we review the advances made in the past year in the field of atherothrombosis and thrombophilia, with the focus placed on results emerging from genome-wide association studies on coronary artery disease, ischemic stroke, venous thromboembolism, and intermediate traits associated with these disease entities.
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Metadata
Title
Genetics of Atherothrombosis and Thrombophilia
Authors
Anders Mälarstig
Anders Hamsten
Publication date
01-05-2010
Publisher
Current Science Inc.
Published in
Current Atherosclerosis Reports / Issue 3/2010
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-010-0101-z

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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