Genetic predisposition to fracture non-union: a case control study of a preliminary single nucleotide polymorphisms analysis of the BMP pathway

go back to reference Praemer A, Furner S, Rice DP: From Musculoskeletal injuries. American Academy of Orthopaedic Surgeons. Musculoskeletal conditions in the United States. 1992, Park Ridge, IL, USA, 85-124. Praemer A, Furner S, Rice DP: From Musculoskeletal injuries. American Academy of Orthopaedic Surgeons. Musculoskeletal conditions in the United States. 1992, Park Ridge, IL, USA, 85-124.

go back to reference Brinker MR: From Nonunions: evaluation and treatment. Skeletal Trauma Basic science management and reconstruction. Edited by: Browner BD, Jupiter JB, Levine AM, Trafton PG. 2003, Philadelphia: Saunders, 507-604. 3 Brinker MR: From Nonunions: evaluation and treatment. Skeletal Trauma Basic science management and reconstruction. Edited by: Browner BD, Jupiter JB, Levine AM, Trafton PG. 2003, Philadelphia: Saunders, 507-604. 3

go back to reference Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P: Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000, 82 (5): 655-658. 10.1302/0301-620X.82B5.9899.CrossRefPubMed Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P: Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000, 82 (5): 655-658. 10.1302/0301-620X.82B5.9899.CrossRefPubMed

go back to reference Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJ, Mascheretti S, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG: The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002, 122 (4): 867-874. 10.1053/gast.2002.32415.CrossRefPubMed Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJ, Mascheretti S, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG: The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002, 122 (4): 867-874. 10.1053/gast.2002.32415.CrossRefPubMed

go back to reference Hyndman ME, Parsons HG, Verma S, Bridge PJ, Edworthy S, Jones C, Lonn E, Charbonneau F, Anderson TJ: The T-786-- > C mutation in endothelial nitric oxide synthase is associated with hypertension. Hypertension. 2002, 39 (4): 919-922. 10.1161/01.HYP.0000013703.07316.7F.CrossRefPubMed Hyndman ME, Parsons HG, Verma S, Bridge PJ, Edworthy S, Jones C, Lonn E, Charbonneau F, Anderson TJ: The T-786-- > C mutation in endothelial nitric oxide synthase is associated with hypertension. Hypertension. 2002, 39 (4): 919-922. 10.1161/01.HYP.0000013703.07316.7F.CrossRefPubMed

go back to reference Raunio H, Husgafvel-Pursiainen K, Anttila S, Hietanen E, Hirvonen A, Pelkonen O: Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review. Gene. 1995, 159 (1): 113-121. 10.1016/0378-1119(94)00448-2.CrossRefPubMed Raunio H, Husgafvel-Pursiainen K, Anttila S, Hietanen E, Hirvonen A, Pelkonen O: Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review. Gene. 1995, 159 (1): 113-121. 10.1016/0378-1119(94)00448-2.CrossRefPubMed

go back to reference Ralston SH: Genetics of osteoporosis. Proc Nutr Soc. 2007, 66 (2): 158-165. 10.1017/S002966510700540X.CrossRefPubMed Ralston SH: Genetics of osteoporosis. Proc Nutr Soc. 2007, 66 (2): 158-165. 10.1017/S002966510700540X.CrossRefPubMed

go back to reference Akbarian S, Huang HS: Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res Rev. 2006, 52 (2): 293-304. 10.1016/j.brainresrev.2006.04.001.CrossRefPubMed Akbarian S, Huang HS: Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res Rev. 2006, 52 (2): 293-304. 10.1016/j.brainresrev.2006.04.001.CrossRefPubMed

go back to reference Nakamura Y: DNA variations in human and medical genetics: 25 years of my experience. J Hum Genet. 2009, 54 (1): 1-8. 10.1038/jhg.2008.6.CrossRefPubMed Nakamura Y: DNA variations in human and medical genetics: 25 years of my experience. J Hum Genet. 2009, 54 (1): 1-8. 10.1038/jhg.2008.6.CrossRefPubMed

go back to reference Dimitriou R, Tsiridis E, Giannoudis PV: Current concepts of molecular aspects of bone healing. Injury. 2005, 36 (12): 1392-1404. 10.1016/j.injury.2005.07.019.CrossRefPubMed Dimitriou R, Tsiridis E, Giannoudis PV: Current concepts of molecular aspects of bone healing. Injury. 2005, 36 (12): 1392-1404. 10.1016/j.injury.2005.07.019.CrossRefPubMed

go back to reference Gazzerro E, Canalis E: Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord. 2006, 7 (1-2): 51-65. 10.1007/s11154-006-9000-6.CrossRefPubMed Gazzerro E, Canalis E: Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord. 2006, 7 (1-2): 51-65. 10.1007/s11154-006-9000-6.CrossRefPubMed

go back to reference Yamashita H, Ten Dijke P, Heldin CH, Miyazono K: Bone morphogenetic protein receptors. Bone. 1996, 19: 569-574. 10.1016/S8756-3282(96)00259-1.CrossRefPubMed Yamashita H, Ten Dijke P, Heldin CH, Miyazono K: Bone morphogenetic protein receptors. Bone. 1996, 19: 569-574. 10.1016/S8756-3282(96)00259-1.CrossRefPubMed

go back to reference Miyazono K: Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone. 1999, 25: 91-93. 10.1016/S8756-3282(99)00113-1.CrossRefPubMed Miyazono K: Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone. 1999, 25: 91-93. 10.1016/S8756-3282(99)00113-1.CrossRefPubMed

go back to reference Dimitriou R, Tsiridis E, Carr I, Simpson H, Giannoudis PV: The role of inhibitory molecules in fracture healing. Injury. 2006, 37 (Suppl 1): 20-29. 10.1016/j.injury.2006.02.039.CrossRef Dimitriou R, Tsiridis E, Carr I, Simpson H, Giannoudis PV: The role of inhibitory molecules in fracture healing. Injury. 2006, 37 (Suppl 1): 20-29. 10.1016/j.injury.2006.02.039.CrossRef

go back to reference Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O'Brien CA, Economides AN, Stahl N, Jilka RL, Manolagas SC: Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res. 2000, 15 (4): 663-673. 10.1359/jbmr.2000.15.4.663.CrossRefPubMed Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O'Brien CA, Economides AN, Stahl N, Jilka RL, Manolagas SC: Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res. 2000, 15 (4): 663-673. 10.1359/jbmr.2000.15.4.663.CrossRefPubMed

go back to reference Zhang H, Bradley A: Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 1996, 122: 2977-2986.PubMed Zhang H, Bradley A: Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 1996, 122: 2977-2986.PubMed

go back to reference Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V: BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006, 38 (12): 1424-1429. 10.1038/ng1916.CrossRefPubMed Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V: BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006, 38 (12): 1424-1429. 10.1038/ng1916.CrossRefPubMed

go back to reference Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G: BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995, 9 (22): 2808-2820. 10.1101/gad.9.22.2808.CrossRefPubMed Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G: BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995, 9 (22): 2808-2820. 10.1101/gad.9.22.2808.CrossRefPubMed

go back to reference Jena N, Martín-Seisdedos C, McCue P, Croce CM: BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res. 1997, 230 (1): 28-37. 10.1006/excr.1996.3411.CrossRefPubMed Jena N, Martín-Seisdedos C, McCue P, Croce CM: BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res. 1997, 230 (1): 28-37. 10.1006/excr.1996.3411.CrossRefPubMed

go back to reference Shintani N, Hunziker EB: Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue. Arthritis Rheum. 2007, 56 (6): 1869-1879. 10.1002/art.22701.CrossRefPubMed Shintani N, Hunziker EB: Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue. Arthritis Rheum. 2007, 56 (6): 1869-1879. 10.1002/art.22701.CrossRefPubMed

go back to reference Devlin RD, Du Z, Pereira RC, Kimble RB, Economides AN, Jorgetti V, Canalis E: Skeletal overexpression of noggin results in osteopenia and reduced Bone formation. Endocrinology. 2003, 144 (5): 1972-1978. 10.1210/en.2002-220918.CrossRefPubMed Devlin RD, Du Z, Pereira RC, Kimble RB, Economides AN, Jorgetti V, Canalis E: Skeletal overexpression of noggin results in osteopenia and reduced Bone formation. Endocrinology. 2003, 144 (5): 1972-1978. 10.1210/en.2002-220918.CrossRefPubMed

go back to reference Wu XB, Li Y, Schneider A, Yu W, Rajendren G, Iqbal J, Yamamoto M, Alam M, Brunet LJ, Blair HC, Zaidi M, Abe E: Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest. 2003, 112 (6): 924-934.CrossRefPubMedPubMedCentral Wu XB, Li Y, Schneider A, Yu W, Rajendren G, Iqbal J, Yamamoto M, Alam M, Brunet LJ, Blair HC, Zaidi M, Abe E: Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest. 2003, 112 (6): 924-934.CrossRefPubMedPubMedCentral

go back to reference Aspenberg P, Jeppsson C, Economides AN: The Bone morphogenetic proteins antagonist noggin inhibits membranous ossification. J Bone Miner Res. 2001, 16 (3): 497-500. 10.1359/jbmr.2001.16.3.497.CrossRefPubMed Aspenberg P, Jeppsson C, Economides AN: The Bone morphogenetic proteins antagonist noggin inhibits membranous ossification. J Bone Miner Res. 2001, 16 (3): 497-500. 10.1359/jbmr.2001.16.3.497.CrossRefPubMed

go back to reference Horiki M, Imamura T, Okamoto M, Hayashi M, Murai J, Myoui A, Ochi T, Miyazono K, Yoshikawa H, Tsumaki N: Smad6/Smurf1 overexpression in cartilage delays chondrocytes hypertrophy and causes dwarfism with osteopenia. J Cell Biol. 2004, 165: 433-445. 10.1083/jcb.200311015.CrossRefPubMedPubMedCentral Horiki M, Imamura T, Okamoto M, Hayashi M, Murai J, Myoui A, Ochi T, Miyazono K, Yoshikawa H, Tsumaki N: Smad6/Smurf1 overexpression in cartilage delays chondrocytes hypertrophy and causes dwarfism with osteopenia. J Cell Biol. 2004, 165: 433-445. 10.1083/jcb.200311015.CrossRefPubMedPubMedCentral

go back to reference Setakis E, Stirnadel H, Balding DJ: Logistic regression protects against population structure in genetic association studies. Genome Res. 2006, 169 (2): 290-226. Setakis E, Stirnadel H, Balding DJ: Logistic regression protects against population structure in genetic association studies. Genome Res. 2006, 169 (2): 290-226.

go back to reference Bland JM, Altman DG: Statistics notes. The odds ratio. BMJ. 2000, 320 (7247): 1468-10.1136/bmj.320.7247.1468.CrossRefPubMedPubMedCentral Bland JM, Altman DG: Statistics notes. The odds ratio. BMJ. 2000, 320 (7247): 1468-10.1136/bmj.320.7247.1468.CrossRefPubMedPubMedCentral

go back to reference Manigrasso MB, O'Connor JP: Comparison of fracture healing among different inbred mouse strains. Calcif Tissue Int. 2008, 82 (6): 465-474. 10.1007/s00223-008-9144-3.CrossRefPubMed Manigrasso MB, O'Connor JP: Comparison of fracture healing among different inbred mouse strains. Calcif Tissue Int. 2008, 82 (6): 465-474. 10.1007/s00223-008-9144-3.CrossRefPubMed

go back to reference Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH: Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mamm Genome. 2007, 18 (6-7): 492-507. 10.1007/s00335-007-9017-5.CrossRefPubMedPubMedCentral Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH: Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mamm Genome. 2007, 18 (6-7): 492-507. 10.1007/s00335-007-9017-5.CrossRefPubMedPubMedCentral

go back to reference Dixon ME, Armstrong P, Stevens DB, Bamshad M: Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism. Genet Med. 2001, 3 (5): 349-353. 10.1097/00125817-200109000-00004.CrossRefPubMed Dixon ME, Armstrong P, Stevens DB, Bamshad M: Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism. Genet Med. 2001, 3 (5): 349-353. 10.1097/00125817-200109000-00004.CrossRefPubMed

go back to reference Lehmann K, Seemann P, Silan F, Goecke TO, Irgang S, Kjaer KW, Kjaergaard S, Mahoney MJ, Morlot S, Reissner C, Kerr B, Wilkie AO, Mundlos S: A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Am J Hum Genet. 2007, 81 (2): 388-396. 10.1086/519697.CrossRefPubMedPubMedCentral Lehmann K, Seemann P, Silan F, Goecke TO, Irgang S, Kjaer KW, Kjaergaard S, Mahoney MJ, Morlot S, Reissner C, Kerr B, Wilkie AO, Mundlos S: A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Am J Hum Genet. 2007, 81 (2): 388-396. 10.1086/519697.CrossRefPubMedPubMedCentral

go back to reference Sémonin O, Fontaine K, Daviaud C, Ayuso C, Lucotte G: Identification of three novel mutations of the noggin gene in patients with fibrodysplasia ossificans progressiva. Am J Med Genet. 2001, 102 (4): 314-317.CrossRefPubMed Sémonin O, Fontaine K, Daviaud C, Ayuso C, Lucotte G: Identification of three novel mutations of the noggin gene in patients with fibrodysplasia ossificans progressiva. Am J Med Genet. 2001, 102 (4): 314-317.CrossRefPubMed

go back to reference Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressive. Nat Genet. 2006, 38 (5): 525-527. 10.1038/ng1783.CrossRefPubMed Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressive. Nat Genet. 2006, 38 (5): 525-527. 10.1038/ng1783.CrossRefPubMed

go back to reference Brunet LJ, McMahon JA, McMahon AP, Harland RM: Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 1998, 280 (5368): 1455-1457. 10.1126/science.280.5368.1455.CrossRefPubMed Brunet LJ, McMahon JA, McMahon AP, Harland RM: Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 1998, 280 (5368): 1455-1457. 10.1126/science.280.5368.1455.CrossRefPubMed

go back to reference Edgar CM, Chakravarthy V, Barnes G, Kakar S, Gerstenfeld LC, Einhorn TA: Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells. Bone. 2007, 40 (5): 1389-1398. 10.1016/j.bone.2007.01.001.CrossRefPubMedPubMedCentral Edgar CM, Chakravarthy V, Barnes G, Kakar S, Gerstenfeld LC, Einhorn TA: Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells. Bone. 2007, 40 (5): 1389-1398. 10.1016/j.bone.2007.01.001.CrossRefPubMedPubMedCentral

go back to reference Yoshimura Y, Nomura S, Kawasaki S, Tsutsumimoto T, Shimizu T, Takaoka K: Colocalization of noggin and bone morphogenetic protein-4 during fracture healing. J Bone Miner Res. 2001, 16 (5): 876-884. 10.1359/jbmr.2001.16.5.876.CrossRefPubMed Yoshimura Y, Nomura S, Kawasaki S, Tsutsumimoto T, Shimizu T, Takaoka K: Colocalization of noggin and bone morphogenetic protein-4 during fracture healing. J Bone Miner Res. 2001, 16 (5): 876-884. 10.1359/jbmr.2001.16.5.876.CrossRefPubMed

go back to reference Urano T, Shiraki M, Usui T, Sasaki N, Ouchi Y, Inoue S: Bone mass effects of a Smad6 gene polymorphism in Japanese postmenopausal women. J Bone Miner Metab. 2009, 27 (5): 562-566. 10.1007/s00774-009-0068-4.CrossRefPubMed Urano T, Shiraki M, Usui T, Sasaki N, Ouchi Y, Inoue S: Bone mass effects of a Smad6 gene polymorphism in Japanese postmenopausal women. J Bone Miner Metab. 2009, 27 (5): 562-566. 10.1007/s00774-009-0068-4.CrossRefPubMed

go back to reference Justesen J, Stenderup K, Eriksen EF, Kassem M: Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int. 2001, 71 (1): 36-44. 10.1007/s00223-001-2059-x.CrossRef Justesen J, Stenderup K, Eriksen EF, Kassem M: Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int. 2001, 71 (1): 36-44. 10.1007/s00223-001-2059-x.CrossRef

go back to reference Jiang Y, Mishima H, Sakai S, Liu YK, Ohyabu Y, Uemura T: Gene expression analysis of major lineage-defining factors in human bone marrow cells: Effect of aging, gender, and age-related disorders. J Orthop Res. 2008, 26 (7): 910-917. 10.1002/jor.20623.CrossRefPubMed Jiang Y, Mishima H, Sakai S, Liu YK, Ohyabu Y, Uemura T: Gene expression analysis of major lineage-defining factors in human bone marrow cells: Effect of aging, gender, and age-related disorders. J Orthop Res. 2008, 26 (7): 910-917. 10.1002/jor.20623.CrossRefPubMed

go back to reference Garcia-Closas M, Troester MA, Qi Y, Langerød A, Yeager M, Lissowska J, Brinton L, Welch R, Peplonska B, Gerhard DS, Gram IT, Kristensen V, Børresen-Dale AL, Chanock S, Perou CM: Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status. Cancer Epidemiol Biomarkers Prev. 2007, 16 (11): 2269-2275. 10.1158/1055-9965.EPI-07-0449.CrossRefPubMed Garcia-Closas M, Troester MA, Qi Y, Langerød A, Yeager M, Lissowska J, Brinton L, Welch R, Peplonska B, Gerhard DS, Gram IT, Kristensen V, Børresen-Dale AL, Chanock S, Perou CM: Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status. Cancer Epidemiol Biomarkers Prev. 2007, 16 (11): 2269-2275. 10.1158/1055-9965.EPI-07-0449.CrossRefPubMed

go back to reference Vonlanthen S, Kawecki TJ, Betticher DC, Pfefferli M, Schwaller B: Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer. Anticancer Res. 2007, 27 (6C): 4279-4288.PubMed Vonlanthen S, Kawecki TJ, Betticher DC, Pfefferli M, Schwaller B: Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer. Anticancer Res. 2007, 27 (6C): 4279-4288.PubMed

go back to reference Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Börner MG, Chiron P, Choong P, Cinats J, Courtenay B, Feibel R, Geulette B, Gravel C, Haas N, Raschke M, Hammacher E, van der Velde D, Hardy P, Holt M, Josten C, Ketterl RL, Lindeque B, Lob G, Mathevon H, McCoy G, Marsh D, Miller R, Munting E, Oevre S, Nordsletten L, Patel A, Pohl A, Rennie W, Reynders P, Rommens PM, Rondia J, Rossouw WC, Daneel PJ, Ruff S, Rüter A, Santavirta S, Schildhauer TA, Gekle C, Schnettler R, Segal D, Seiler H, Snowdowne RB, Stapert J, Taglang G, Verdonk R, Vogels L, Weckbach A, Wentzensen A, Wisniewski T, BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group: Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002, 84 (12): 2123-2134.PubMed Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Börner MG, Chiron P, Choong P, Cinats J, Courtenay B, Feibel R, Geulette B, Gravel C, Haas N, Raschke M, Hammacher E, van der Velde D, Hardy P, Holt M, Josten C, Ketterl RL, Lindeque B, Lob G, Mathevon H, McCoy G, Marsh D, Miller R, Munting E, Oevre S, Nordsletten L, Patel A, Pohl A, Rennie W, Reynders P, Rommens PM, Rondia J, Rossouw WC, Daneel PJ, Ruff S, Rüter A, Santavirta S, Schildhauer TA, Gekle C, Schnettler R, Segal D, Seiler H, Snowdowne RB, Stapert J, Taglang G, Verdonk R, Vogels L, Weckbach A, Wentzensen A, Wisniewski T, BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group: Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002, 84 (12): 2123-2134.PubMed

go back to reference Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S: Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001, 83 (Suppl A): 151-158. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S: Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am. 2001, 83 (Suppl A): 151-158.