Published in:
01-01-2012 | Letter to the Editor
Genetic polymorphisms of clusterin gene are associated with a decreased risk of Alzheimer’s disease
Authors:
Yen-Ling Lin, Shih-Yuan Chen, Liang-Chuan Lai, Jen-Hau Chen, Shi-Yi Yang, Yi-Ling Huang, Ta-Fu Chen, Yu Sun, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J. Chen, Yen-Ching Chen
Published in:
European Journal of Epidemiology
|
Issue 1/2012
Login to get access
Excerpt
Clusterin (
CLU) is located on chromosome 8p21–p12. The binding of
CLU to Aβ facilitates Aβ clearance and transporting of
CLU- Aβ complex. Recent Caucasian genome-wide association studies (GWASs) found that
CLU rs11136000 is the only SNP consistently associated with a reduced risk of Alzheimer’s disease (AD) [odds ratio (OR) = 0.85–0.86] [
1‐
3], similar findings were observed in two Caucasian candidate-gene studies [
4,
5], while the other two Caucasian studies did not observe this association [
6,
7]. In contrast, a Chinese study observed an opposite association (OR = 1.39) [
8]. …
