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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2009

Open Access 01-12-2009 | Research

Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck

Authors: Michal Kowalski, Karolina Przybylowska, Pawel Rusin, Jurek Olszewski, Alina Morawiec-Sztandera, Anna Bielecka-Kowalska, Wioletta Pietruszewska, Wojciech Mlynarski, Szemraj Janusz, Ireneusz Majsterek

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2009

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Abstract

Background

The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single nucleotide polymorphisms (SNPs) of XRCC1 gene with human head and neck squamous cell carcinoma (HNSCC).

Methods

The genotype analysis of Arg194Trp and Arg399Gln gene polymorphisms for 92 HNSCC patients and 124 controls of cancer free subjects, in Polish population were performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP) with endonuclease Msp I.

Results

No altered risk has been found individually for these SNPs, however haplotypes analysis showed high association with head and neck cancer. The highest frequency, according to wild-type of Arg194Arg and Arg399Arg genotypes, was identified for Arg194Trp-Arg399Arg haplotype (OR, 2.96; 95% CI, 1.01–8.80).

Conclusion

Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene XRCC1 that was associated with HNSCC and may have an impact on identification of a high-risk cancer population.
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Metadata
Title
Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck
Authors
Michal Kowalski
Karolina Przybylowska
Pawel Rusin
Jurek Olszewski
Alina Morawiec-Sztandera
Anna Bielecka-Kowalska
Wioletta Pietruszewska
Wojciech Mlynarski
Szemraj Janusz
Ireneusz Majsterek
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2009
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/1756-9966-28-37

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