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BMC Cancer
Published in: BMC Cancer 1/2012

Open Access 01-12-2012 | Research article

Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Authors: Peng Zhao, Lin Zhao, Peng Zou, Ailin Lu, Ning Liu, Wei Yan, Chunsheng Kang, Zhen Fu, Yongping You, Tao Jiang

Published in: BMC Cancer | Issue 1/2012

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Abstract

Background

The oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and glioma risk are currently unknown. We therefore investigated the association between polymorphisms in antioxidant genes and glioma risk.

Methods

We examined 16 single nucleotide polymorphisms (SNPs) of 9 antioxidant genes (GPX1, CAT, PON1, NQO1, SOD2/MnSOD, SOD3, and NOS1*2*3) in 384 glioma and 384 control cases in a Chinese hospital-based case–control study. Genotypes were determined using the OpenArray platform, which employs the chip-based Taq-Man genotyping technology. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using unconditional logistic regression.

Results

Using single-locus analysis, we identified four SNPs (SOD2 V16A, SOD3 T58A, GPX1 -46 C/T, and NOS1 3’-UTR) that were significantly associated with the risk of glioma development. To assess the cumulative effects, we performed a combined unfavourable genotype analysis. Compared with the reference group that exhibited no unfavourable genotypes, the medium- and high-risk groups exhibited a 1.86-fold (95% CI, 1.30-2.67) and a 4.86-fold (95% CI, 1.33-17.71) increased risk of glioma, respectively (P-value for the trend < 0.001).

Conclusions

These data suggest that genetic variations in oxidative stress genes might contribute to the aetiology of glioma.
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Metadata
Title
Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study
Authors
Peng Zhao
Lin Zhao
Peng Zou
Ailin Lu
Ning Liu
Wei Yan
Chunsheng Kang
Zhen Fu
Yongping You
Tao Jiang
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2012
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-12-617

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